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Acil ünitesine intihar girişimi nedeniyle başvuran olguların değerlendirilmesi: Şanlıurfa örneklemi
(Turkish Association for Psychopharmacology, 2014) Atlı, Abdullah; Uysal, Cem; Kaya, Mehmet Cemal; Bulut, Mahmut; Güneş, Mehmet; Karababa, İbrahim Fatih; Bez, Yasin; Beşaltı, Sever; Sır, Aytekin
Amaç: İntihar, istemli olarak kişinin yaşamına son vermesidir. Dünya Sağlık Örgütüne göre her yıl bir milyondan fazla insan intihar etmektedir ve dünyada yaşanan ölümlerin %2’si intihar nedeniyledir. Ülkemizde 2011 yılı istatistiklerine göre 2677 kişi intihar etmiştir ve kaba intihar hızı %3.62 olarak bulunmuştur. Bu çalışmada amacımız Şanlıurfa ilinde intihar girişimi nedeni ile acil servise başvuran hastaların özelliklerini ortaya koymaktır. Yöntem: Çalışmamız geriye dönük bir çalışma olup, Şanlıurfa ilindeki Balıklıgöl Devlet Hastanesi acil servisine intihar girişimi nedeniyle başvuran bireyler çalışmaya dâhil edildi. Bireylerin tıbbi kayıtlarındaki bazı klinik ve fenomenolojik özellikleri incelenmiştir. Bulgular: 2011 yılı içinde hastane acil servisine 227 kişinin intihar girişimi nedeni ile başvurduğu anlaşılmıştır. Başvuranların 177’si (%78) kadın, 78’i (%22) erkekti. Hastaların %57’si 15-24 yaş aralığındaydı ve %51’i evliydi. En sık intihar şeklinin yüksek doz ilaç alma olduğu tespit edilmiştir. İntihar girişimlerinin yaklaşık yarısının (%49.8) 16-24 saatleri arası gerçekleştirildiği görülmüştür. En sık intihar nedeni ise aile içi sorunlar olarak bildirilmişti (%37.9). Sonuç: Araştırmamızdaki acil servise intihar girişimi nedeni ile yapılan başvuruların yarısından fazlasının evli ve 15-24 yaş aralığında olması bu bölgede aile içi sorunların intihar girişimleri için önemli bir risk etmeni olduğunu düşündürmektedir. En sık intihar nedeni olarak aile içi sorunların bildirilmiş olması bu düşünceyi destekler niteliktedir. İntihar girişimleri açısından depresyon, borderline kişilik özellikleri, fiziksel-cinsel travma, impulsivite gibi psikiyatrik rahatsızlıklarla beraber aile içi sorunlar ve eşler arası geçimsizlik gibi sosyal etmenler önemli yer tutmaktadır. Sonuç olarak; çalışmamızın verileri bir bütün olarak incelendiğinde ve Türkiye’nin diğer bölgelerinde yapılan benzer çalışmalarla karşılaştırıldığında; evli olmak, genç olmak, eğitim düzeyinin düşük olması ve aile içi sorunlar ile intihar girişimleri arasında ilişki bulunmaktadır. Yetkili kurumların bazı önlemler almasının intihar girişimlerini azaltmada etkili olabileceği düşünülmektedir.
Acute unilateral myopia induced by add-on aripiprazole: A case report
(2016) Bulut, Mahmut; Atli, Abdullah; Kaya, Mehmet Cemal; Demir, Süleyman; İbiloğlu, Aslıhan Okan; Güneş, Mehmet; Yüksel, Harun
The partial agonist aripiprazole is a novel atypical antipsychotic with a relatively safer side effect profile. Acute unilateral myopia is a very rare condition that is commonly associated with drug use. Here, we present a woman diagnosed with obsessive-compulsive disorder (OCD) and major depressive disorder (MDD) who have been treated for two years in our clinic. She was on fluoxetine (Prozac) 80 mg/day when adding aripiprazole (Abilify) 10 mg/day as an augmentation agent has triggered unilateral myopia. After cessation of aripirazole her myopia has disappeared. Psychiatrists should keep in mind that unilateral myopia as a side effect may develop after combining aripiprazole with fluoxetine in patients with OCD and MDD.
Acute Unilateral Myopia Induced by Add-On Aripiprazole: A Case Report
(Kure Iletisim Grubu A S, 2016) Gunes, Mehmet; Demir, Suleyman; Bulut, Mahmut; Kaya, Mehmet Cemal; Atli, Abdullah; Ibiloglu, Aslihan Okan; Yuksel, Harun
The partial agonist aripiprazole is a novel atypical antipsychotic with a relatively safer side effect profile. Acute unilateral myopia is a very rare condition that is commonly associated with drug use. Here, we present a woman diagnosed with obsessive-compulsive disorder (OCD) and major depressive disorder (MDD) who have been treated for two years in our clinic. She was on fluoxetine (Prozac) 80 mg/day when adding aripiprazole (Abilify) 10 mg/day as an augmentation agent has triggered unilateral myopia. After cessation of aripirazole her myopia has disappeared. Psychiatrists should keep in mind that unilateral myopia as a side effect may develop after combining aripiprazole with fluoxetine in patients with OCD and MDD.
Antioxidant Status and DNA Damage in Children with Attention Deficit Hyperactivity Disorder with or without Comorbid Disruptive Behavioral Disorders
(Kure Iletisim Grubu A S, 2016) Simsek, Seref; Gencoglan, Salih; Ozaner, Soner; Kaplan, Ibrahim; Kaya, Mehmet Cemal
Objective: The aim of this study is to investigate oxidative stress and DNA damage among children with attention deficit hyperactivity disorder (ADHD) with or without disruptive behavioral disorders (DBD). Methods: A total of 49 treatment naive children (M/F: 40/9) who were diagnosed with ADHD according to the Diagnostic and Statistical Manual of Mental Disorders (DSM) IV criteria were included. The patients with ADHD were divided into two groups, those with ADHD alone (n= 25) and ADHD plus DBD (n= 24). The control group consisted of 40 age-and sex-similar healthy children. The Schedule for Affective Disorders and Schizophrenia for School Aged Children-Present and Life-time version (K-SADS-PL) was applied to all children. Children's teachers completed the Turgay DSM-IV Based Child and Adolescent Behavior Disorders Screening and Rating Scale (T-DSM-IV-S). Serum glutathione peroxidase (GPx), coenzyme Q, 8-hydroxy-2-deoxyguanosine (8-OHdG) and superoxide dismutase (SOD) levels were measured by the ELISA method using commercial kits. Results: There were no significant differences in serum GPx, SOD, CoQ and 8-OHdG levels among the pure ADHD, ADHD plus DBD and the control groups (p>0.05). No statistically significant correlations were found between the severity of ADHD symptoms and GPx, SOD, CoQ and 8-OHdG levels. Conclusion: Our study suggests that oxidative stress may not play a key role in the pathogenesis of pure ADHD and ADHD plus DBD.
Anxiety, depression, sexual dysfunction and quality of life in prostate cancer based on stage of the disease
(Yerkure Tanitim & Yayincilik Hizmetleri A S, 2013) Kaya, Mehmet Cemal; Bez, Yasin; Demir, Aslan; Bulut, Mahmut; Topcuoglu, Volkan; Kuscu, Mehmet Kemal; Turkeri, Niyazi Levent
Background: Prostate cancer is common in men and in many studies quality of life, mental health problems and sexual dysfunction were examined in this population. However, there are relatively few studies examining the impact of the disease according to the stages. In this study we aimed to compare the levels of anxiety, depression, quality of life and sexual dysfunction of the prostate cancer patients according to their stages. Method: 80 patients with prostate cancer who applied to urology outpatient clinic were enrolled to the study. Patients were divided into three groups according to their stages; localized/organ-confined, local spread and metastatic spread. Short Form 36 (SF-36), Hospital Anxiety and Depression Scale (HAD) and the Arizona Sexual Experience Scale (ASEX) were performed. Results: According to the stage of prostate cancer, physical functioning subscale of quality of life was significantly lower in patients with metastatic prostate cancer than in patients with organ-confined prostate cancer (F=4.53, p=0.014). There were no associations between anxiety and depression scores and the stage of prostate cancer. Sexual desire was better in organ-confined prostate cancer patients compared to metastatic prostate cancer patients (F=5.32, p=0.007). Conclusion: The patients with prostate cancer might have different levels of physical functioning and sexual aversion problems at different stages of the disease. The clinicians should consider these two issues during follow-up of these patients.
Are oxidative stress markers useful to distinguish schizoaffective disorder from schizophrenia and bipolar disorder?
(Cambridge Univ Press, 2014) Bulbul, Feridun; Virit, Osman; Alpak, Gokay; Unal, Ahmet; Bulut, Mahmut; Kaya, Mehmet Cemal; Altindag, Abdurrahman
Objective Schizoaffective disorder is a disease with both affective and psychotic symptoms. In this study, we aimed to compare oxidative metabolism markers of schizoaffective disorder, bipolar disorder and schizophrenic patients. Furthermore, we also aimed to investigate whether schizoaffective disorder could be differentiated from schizophrenia and bipolar disorder in terms of oxidative metabolism. Methods Total oxidant status (TOS) and total antioxidant status (TAS) were measured in the blood samples that were collected from schizoaffective patients (n = 30), bipolar disorder patients (n = 30) and schizophrenic patients (n = 30). Oxidative stress index (OSI) was calculated by dividing TOS by TAS. Results TOS and OSI were found to be higher in patients with schizoaffective disorder compared with those in schizophrenia and bipolar disorder patients. TAS was not significantly different between the groups. Conclusion Schizoaffective disorder was found to be different from bipolar disorder and schizophrenia in terms of oxidative parameters. This result may indicate that schizoaffective disorder could differ from bipolar disorder and schizophrenia in terms of biochemical parameters. Increased TOS levels observed in schizoaffective disorder may suggest poor clinical course and may be an indicator of poor prognosis.
Aripiprozole-induced diplopia: A case report
(2013) Kaya, Mehmet Cemal; Aydın, Yıldız; Atlı, Abdullah; Selvi, Yavuz
Diplopi çift görme olarak tanımlanan ve yaşam kalitesinibozan bir durumdur. Akut diplopi bazı genel tıbbiilaçlar ve psikotrop ilaç kullanımında görülmektedir.Aripiprazol D2 ve 5-HT1A reseptörlerine parsiyel agonistve 5-HT2A reseptörlerine antagonist aktivite gösterenatipik antipsikotik ajandır. Bu yazıda şizofreniformbozukluk tanısıyla takip edilen 24 yaşındaki birhastada, oral aripiprazol kullanımını takiben ortayaçıkan, diplopi olgusu bildirilmektedir. Klinisyenleraripiprazol tedavisiyle diplopi ortaya çıkabileceğiniakılda tutmalıdırlar.
Aripiprozole-Induced Diplopia: A Case Report
(Kure Iletisim Grubu A S, 2013) Atli, Abdullah; Selvi, Yavuz; Yildiz, Aydin; Kaya, Mehmet Cemal
Diplopia is a condition that involves seeing double and impairs quality of life. Acute diplopia can be seen with some general medical drugs and psychotropic drugs. Aripiprazole is a new atypical antipsychotic agent; it has partial agonist activity at D2 and 5-HT1A receptors and antagonist activity at 5-HT2A receptors. This paper reports development of diplopia, a rare adverse effect of psychotropic drugs, in a 24 year old patient with schizophreniform disorder following use of oral aripiprazole. Clinicians should keep in mind that diplopia may occur with aripiprazole treatment.
A Case of Skin Picking Disorder of a Patient with a History of Childhood Abuse
(Aves, 2016) Okan Ibiloglu, Aslihan; Atli, Abdullah; Kaya, Mehmet Cemal; Demir, Suleyman; Bulut, Mahmut; Sir, Aytekin
Skin picking (excoriation) disorder is the recurrent excoriation of one's own skin, resulting in noticeable skin damage. People pick their skin for different reasons. For the majority of patients, first skin picking is associated with a history of childhood abuse and personal problems. Subjects who moderately to severely cause injurious self-harm are more likely to have a history of exposure to domestic violence and childhood abuse than those who do not self-harm. At the same time, these conditions could be related to the etiology for majority of other psychiatric disorders. We report herein, a case of a patient with skin picking disorder who had a history of childhood physical and emotional abuse with borderline personality disorder.
Çocuk evliliği yapan kadınlarda çift uyumu ve çocukluk çağı ruhsal travması
(Türk Psikofarmakoloji Derneği, 2016) Güneş, Mehmet; Selçuk, Hilal; Demir, Süleyman; İbiloğlu, Aslıhan Okan; Bulut, Mahmut; Kaya, Mehmet Cemal; Yılmaz, Ahmet; Atli, Abdullah; Sır, Aytekin
Öz:Amaç: Çocuk evliliği yapan kadınların işlevselliklerini bozan birçok problemlerle karşılaştıkları bildirilmiştir. Çocuk evliliği yapan kadınların çocukluk çağında daha fazla ruhsal travmaya maruz kalmış olabileceğini ve çift uyumlarının daha fazla bozulmuş olabileceği düşünülmektedir. Bu çalışmada çocuk evliliği yapan kadınlarda çocukluk çağı ruhsal travmasını ve çift uyumunu araştırmayı amaçladık.Yöntem: Çalışmanın örneklemi 2013 yılı Temmuz-Ağustos ayları arasında Dicle Üniversitesi Kadın Doğum ve Hastalıkları Polikliniğine rutin gebelik kontrolü için başvuran gebe kadınlardan seçildi. Çalışma grubu rutin gebelik kontrolü için başvuran 83 gebe arasından çalışma kriterlerini sağlayan 50 çocuk evliliği (18 yaşından önce evlenmiş) yapmış olan gebe kadın seçilerek oluşturuldu. Kontrol grubu ise 18 yaşından sonra evlenmiş 87 gebe kadın arasından çalışma kriterlerini sağlayan sağlıklı 50 gebe kadın seçilerek oluşturuldu. Tüm katılımcılar psikiyatrist tarafından standardize edilmiş görüşme aracı olan SCID kullanılarak değerlendirildi. Araştırmacılar tarafından oluşturulan sosyodemografik veri formu, Çocukluk Çağı Ruhsal Travma Ölçeği (ÇÇRTÖ), Çift Uyum Ölçeği (ÇUÖ) ve Arizona Cinsel Yaşantılar Ölçeği (ACYÖ) uygulandı.Bulgular: Çift uyumu eşler arası birliktelik boyutu (EABB) ve duygulanım ifade boyutu (DİB) alt ölçek puanları çalışma grubunda kontrol grubuna kıyasla istatistiksel olarak anlamlı düzeyde daha düşük bulunmuştur (sırasıyla p=0.015, p=0.003). Çift uyumunu en sık çocukluk çağı ruhsal travması, evlenme yaşı, ilk gebelik yaşı, cinsel istismar ve cinsel şiddete maruz kalma gibi faktörlerin etkilediği bulundu. ÇÇRTÖ'de emosyonel istismar (p=0.04) ve fiziksel ihmal (p=0.035) puanları çalışma grubunda kontrol grubuna kıyasla istatistiksel olarak anlamlı düzeyde daha yüksek bulunmuştur. Ayrıca çalışma grubunda kontrol grubuna kıyasla evliliğin ilk yıllarında fiziksel (p=0.001) ve cinsel şiddete (p=0.007) maruz kalma oranları istatistiksel olarak anlamlı düzeyde daha yüksek bulunmuştur. Cinsel istek, cinsel uyarılma ve ACYÖ toplam puanı çalışma grubunda kontrol grubuna kıyasla istatistiksel olarak anlamlı derecede farklı bulunmuştur (sırasıyla p=0.012, p=0.034, p=0.048).Sonuç: Çalışmamız çocuk evliliği yapanlarda çift uyumu ile çocukluk çağı travması ve cinsel işlevlerin birlikte değerlendirildiği ilk çalışmadır. Çalışmamızda çocuk evliliği yapanların çift uyumunun bozulmuş olduğu ve buna en fazla çocukluk çağı ruhsal travması, erken yaşta evlenme, çocuk yaşta gebe kalma, cinsel istismar ve cinsel şiddete maruz kalmanın neden olduğu belirlenmiştir. Çalışmamızda çocuk evliliği yapanların çocukluk çağında daha fazla emosyonel istismar, fiziksel ihmale / şiddet ve cinsel şiddete maruz kaldıkları tespit edilmiştir. Ayrıca çocuk evliliği yapan kadınların cinsel işlevlerinin önemli oranda bozulduğu tespit edilmiştir.
Çocukluk Çağı İstismar Öyküsü Olan Cilt Yolma Bozukluğu Olgusu
(2016) Bulut, Mahmut; Atlı, Abdullah; Sır, Aytekin; Kaya, Mehmet Cemal; İbiloğlu, Aslıhan Okan; Demir, Süleyman
Cilt yolma bozukluğu, kişinin kendi cildini tekrarlayıcı biçimde yolarak, belirgincilt hasarının oluşmasıdır. İnsanlar farklı nedenlerle ciltlerini yolmaktadır.Hastaların çoğunda cilt yolmaya başlama ile çocukluk çağı istismaröyküsü ve kişisel sorunlar bağlantılıdır. Orta şiddetten ciddi dereceye kadarkendine zarar veren bireylerde, çocukluk çağı istismarı ve aile içi şiddetemaruz kalma öyküsünün varlığı, kendine zarar vermeyenlere göre,daha muhtemeldir. Bununla beraber, bu durum psikiyatrik bozukluklarınçoğunluğunun etyolojisi ile ilişkili olabilir. Burada borderline (sınır) kişilikbozukluğu ile birlikte çocukluk çağı fiziksel ve duygusal istismar öyküsüolan, bir cilt yolma bozukluğu olgusunu sunacağız.
Comparison of clinical characteristics of patients on whom electroconvulsive therapy was applied as inpatient and outpatient
(Turkish Association for Psychopharmacology, 2016) Demir, Süleyman; Bulut, Mahmut; Atli, Abdullah; Güneş, Mehmet; Kaya, Mehmet Cemal; İbiloğlu, Aslıhan Okan; Çatı, Songül; Sır, Aytekin
Objective: Electroconvulsive therapy (ECT) is an efficient and reliable somatic treatment used to treat severe mental disorders. ECT procedure is generally performed by hospitalizing the patient in our country (Turkey). However, there is no obligation to perform ECT by hospitalization, as ECT may be performed without hospitalizing the patient. Outpatient ECT gradually increases during acute and maintenance treatment. Outpatient ECT provides some advantages, such as reduced disruption in social and professional functionality and decrease in treatment costs. Studies that compare acute outpatient ECT and ECT applied after hospitalization are limited. In the present study, we aimed to review clinical characteristics of acute ambulatory ECT and ECT applied by hospitalization comprehensively and retrospectively. Methods: Inpatients and outpatients that received ECT in the Psychiatry Clinic of Dicle University between 2011 and 2014 were enrolled in the present study. Patients’ files between aforementioned years were reviewed retrospectively and data including patient age, gender, diagnosis according to DSM system, hospitalization period, whether ECT was applied, number of ECT sessions, and whether ECT was performed as an inpatient or outpatient procedure were recorded. For the patients who were hospitalized multiple times, each hospitalization was regarded as a different patient and data were assessed independently. For the outpatients who received ECT, all separate ECT sessions were added and ECT count was determined. Those who received maintenance ECT sessions were not included in the outpatient ECT group. Patients who received ECT by acute referral as outpatients were included in this group. Results: Between 2011 and 2014, 904 patients were admitted to the Psychiatry Clinic of Dicle University, Faculty of Medicine , of which 138 received ECT treatment. We also included in the study an additional 38 outpatients who received acute ECT. Inpatients of our clinic in application to ECT were rates of 15.3%. There was no statistically significant difference detected between age, number of ECT sessions applied, diagnosis, and gender of admitted inpatients and outpatients (p>0.05). Conclusions: In our study clinical characteristics of inpatients and outpatients subjects who admitted in order to practiced the ECT were determined to be similar. We believe that an efficient treatment method may be presented to the patients by including acute outpatient ECT more frequently in the treatment plan from physicians
Comparison of Clinical Characteristics of Patients on whom Electroconvulsive Therapy was Applied as Inpatient and Outpatient
(2016) Bulut, Mahmut; İbiloğlu, Aslıhan Okan; Çatı, Songül; Atli, Abdullah; Demir, Süleyman; Kaya, Mehmet Cemal; Sır, Aytekin
Objective: Electroconvulsive therapy (ECT) is an efficient and reliable somatic treatment used to treat severe mental disorders. ECT procedure is generally performed by hospitalizing the patient in our country (Turkey). However, there is no obligation to perform ECT by hospitalization, as ECT may be performed without hospitalizing the patient. Outpatient ECT gradually increases during acute and maintenance treatment. Outpatient ECT provides some advantages, such as reduced disruption in social and professional functionality and decrease in treatment costs. Studies that compare acute outpatient ECT and ECT applied after hospitalization are limited. In the present study, we aimed to review clinical characteristics of acute ambulatory ECT and ECT applied by hospitalization comprehensively and retrospectively.Methods: Inpatients and outpatients that received ECT in the Psychiatry Clinic of Dicle University between 2011 and 2014 were enrolled in the present study. Patients' files between aforementioned years were reviewed retrospectively and data including patient age, gender, diagnosis according to DSM system, hospitalization period, whether ECT was applied, number of ECT sessions, and whether ECT was performed as an inpatient or outpatient procedure were recorded. For the patients who were hospitalized multiple times, each hospitalization was regarded as a different patient and data were assessed independently. For the outpatients who received ECT, all separate ECT sessions were added and ECT count was determined. Those who received maintenance ECT sessions were not included in the outpatient ECT group. Patients who received ECT by acute referral as outpatients were included in this group.Results: Between 2011 and 2014, 904 patients were admitted to the Psychiatry Clinic of Dicle University, Faculty of Medicine , of which 138 received ECT treatment. We also included in the study an additional 38 outpatients who received acute ECT. Inpatients of our clinic in application to ECT were rates of 15.3%. There was no statistically significant difference detected between age, number of ECT sessions applied, diagnosis, and gender of admitted inpatients and outpatients (p>0.05). Conclusions: In our study clinical characteristics of inpatients and outpatients subjects who admitted in order to practiced the ECT were determined to be similar. We believe that an efficient treatment method may be presented to the patients by including acute outpatient ECT more frequently in the treatment plan from physicians.
Cotard Syndrome Triggered by the COVID-19 Pandemic: Case Report
(Yerkure Tanitim & Yayincilik Hizmetleri A S, 2022) Inan, Ezgi Cankaya; Kaya, Mehmet Cemal
Cotard syndrome (CS) is a rare one characterized by the presence of nihilistic delusions. It is typically associated with depression and is mostly seen in middle-aged women (1). A few cases have been reported in youth, of which 90% are women. Here we present a young female case diagnosed with CS. This patient is the first report of the syndrome triggered by the COVID-19 (Coronavirus disease 2019) pandemic.
Decreased Prolidase Activity in Patients with Posttraumatic Stress Disorder
(Korean Neuropsychiatric Assoc, 2016) Demir, Suleyman; Bulut, Mahmut; Atli, Abdullah; Kaplan, Ibrahim; Kaya, Mehmet Cemal; Bez, Yasin; Ozdemir, Pinar Guzel
Objective Many neurochemical systems have been implicated in the development of Posttraumatic Stress Disorder (PTSD). The prolidase enzyme is a cytosolic exopeptidase that detaches proline or hydroxyproline from the carboxyl terminal position of dipeptides. Prolidase has important biological effects, and to date, its role in the etiology of PTSD has not been studied. In the present study, we aimed to evaluate prolidase activity in patients with PTSD. Methods The study group consisted of patients who were diagnosed with PTSD after the earthquake that occurred in the province of Van in Turkey in 2011 (n=25); the first control group consisted of patients who experienced the earthquake but did not show PTSD symptoms (n=26) and the second control group consisted of patients who have never been exposed to a traumatic event (n=25). Prolidase activities in the patients and the control groups were determined by the ELISA method using commercial kits. Results Prolidase activity in the patient group was significantly lower when compared to the control groups. Prolidase activity was also significantly lower in the traumatized healthy subjects compared to the other healthy group (p<0.01). Conclusion The findings of the present study suggest that the decrease in prolidase activity may have neuroprotective effects in patients with PTSD.
Decreased Serum Sulphydryl Levels as a Sign of Increased Oxidative Stress in Generalized Anxiety Disorder
(Korean Neuropsychiatric Assoc, 2013) Kaya, Mehmet Cemal; Bez, Yasin; Karababa, Ibrahim Fatih; Emhan, Ali; Aksoy, Nurten; Bulut, Mahmut; Gunes, Mehmet
Objective In recent years, many published studies have focused on the relationship between oxidative stress and psychiatric disorders. However, studies in generalized anxiety disorder (GAD) are few despite relatively high prevalence rates. In an attempt to fill this gap in the literature we aimed to measure serum levels of free sulphydryl, an important member of antioxidant defense mechanisms, of the patients with GAD. Methods A total of 35 (23 female, 12 male) GAD patients without any other co-morbid medical or psychiatric disorder and 35 (23 female, 12 male) healthy controls have been included in the study. Disease severity of the patients were quantified by using the Hamilton Anxiety Rating Scale (HAM-A). Serum free sulphydryl group levels of patients and healthy controls were measured in an appropriate way. Results Mean level of serum sulphydryl groups was significantly lower in the patient group. There was a negative correlation between their level and the disease duration. However, they did not show any significant correlation with the disease severity. Conclusion Decreased serum sulphydryl level observed in pure GAD patients suggests an increased oxidative stress in these patients. Well designed future researches are needed to replicate our findings and to test the implications of the present study.
Diagnostic performance of increased prolidase activity in schizophrenia
(Elsevier Ireland Ltd, 2016) Gunes, Mehmet; Bulut, Mahmut; Demir, Suleyman; Ibiloglu, Aslihan Okan; Kaya, Mehmet Cemal; Atli, Abdullah; Kaplan, Ibrahim
We investigated whether prolidase activity has a diagnostic test value in schizophrenia and assessed the relation between prolidase activity and sociodemographic-clinical characteristics of patients with schizophrenia. Fifty patients with schizophrenia (diagnosed as schizophrenia according to DSM-V criteria) and 50 healthy volunteers were included in this study. Case and control groups had a similar distribution in age, sex, body mass index (BMI), and smoking status. Serum prolidase activity was measured in both groups and was determined to be significantly higher in the patient group (509.706 +/- 41.918) compared to the control group (335.4 +/- 13.6; t = 6.231; p = 0.0001). A cut-off point of 392.65 U/L prolidase was determined for diagnostic measures from the plotted ROC curve. The area under the ROC curve was 1.000, which was significant (p < 0.0001). Higher values were assigned as the disease state. Both positive predictive value (PPV) and negative predictive value (NPV) were 100% at the cut-off point of 392.650 U/L. The prolidase levels of the control group were all below the cut-off point. There were no statistically significant differences between the two groups with regard to age, gender, or BMI (p > 0.05), and no correlation was found between mean prolidase activity and age of onset of the disease, family history, disease duration, number of hospitalizations, subtypes of schizophrenia, PANSS scores or sub scores, CGI-S scores, S-A scale scores, and the antipsychotic treatment (p > 0.05). The results of this study indicate that serum prolidase activity may be a useful diagnostic test for schizophrenia; however, further studies are needed to verify this. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
Dicle Üniversitesi hastaneleri özürlü kuruluna başvuran olguların incelenmesi
(T. C. Adalet Bakanlığı Adli Tıp Kurumu, 2013) Uysal, Cem; Bulut, Mahmut; Kaya, Mehmet Cemal; Güneş, Mehmet; Bez, Yasin; Zeren, Cem; Taş, Cuma; Uyar, Betül; Karaaslan, Bekir; Gören, Süleyman
Amaç: Dünya Sağlık Örgütü (DSÖ) gelişmiş ülkelerde nüfusun %10unu, gelişmekte olan ül- kelerde ise %12sini özürlü bi- reylerin oluşturduğunu kabul etmektedir. Türkiye İstatistik Kurumu (TUİK)nun yapmış ol- duğu 2002 Türkiye Özürlüler Araştırması sonuçlarına göre ülkemizde özürlü olan nüfu- sun toplam nüfus içindeki ora- nı %12,29 idi. Bu çalışmamız da özürlülerle ilgili ülkemiz verile- rine katkıda bulunmak amacıyla yapılmıştır. Yöntemler: Hastanemiz özürlü kuruluna 2011 yılı Ocak - Aralık aylarında başvuran 1805 vakaya ait dosya- lar geriye dönük olarak değer- lendirilmiştir. Bulgular: 1805 vakanın %45,4 ü (820 kişi) kadın %54,6 sı (985 kişi) ise erkekti. En fazla başvuru 228 (%12,6) vaka ile Mart ayında gerçekleşmişti. %50den daha az özrü olduğuna karar verilen 1173 (%65) vaka varken, kalan 541 (%30) vakanın özrünün %50 ve üzerinde olduğu tespit edil- miştir. Verilen özür oranlarının süreleri incelendiği zaman; Tüm başvurular içerisinde 873 olgu- nun (%48,4) sürekli özre sahip olduğu görülmüştür. Sonuç: Özürlülüğe yol açan etmenler minimuma indirilmelidir. Alına- cak tedbirler sadece büyükşe- hir kent merkezinde değil diğer küçük yerleşim bölgelerinde de uygulanmalıdır.
Diz osteoartritli hastalarda uyku kalitesinin ağrı, radyolojik hasar, fonksiyonel durum ve depresif semptomlar ile ilişkisi
(Modestum Publishing Ltd., 2013) Sarıyıldız, Mustafa Akif; Batmaz, İbrahim; Kaya, Mehmet Cemal; Bozkurt, Mehtap; Okçu, Mehmet; Yıldız, Mehmet; Yazmalar, Levent; Çelepkolu, Tahsin
Amaç: Bu çalışmanın amacı diz osteoartriti (OA) tanılı hastalarda uyku kalitesini değerlendirmek ve uyku kalitesi ile klinik parametreler, ağrı, fonksiyonel durum, radyolojik hasar ve psikolojik durum arasındaki ilişkiyi incelemektir. Yöntemler: Diz osteoartriti tanılı 52 hasta ve 35 sağlıklı gönüllü çalışmaya dahil edildi. Hastaların yaş, eğitim seviyesi, medeni durumu gibi demografik özellikleri kaydedildi. Hastalıkla ilişkili yeti yitimi, Western Ontario ve McMaster Üniversitesi Osteoartrit indeksi (WOMAC) ile değerlendirildi. Genel ağrı, genel yorgunluk ve diz ağrısı seviyesi görsel analog skala ile değerlendirildi. Psikolojik durum hastane anksiyete depresyon skalası ile ölçüldü. Diz osteoartritinin radyolojik evresi Kellgren Lawrence skoruna göre hesaplandı. Hasta ve kontrol grubunun uyku kalitesi, Pittsburgh uyku kalitesi indeksi (PUKİ) yardımıyla değerlendirildi. Bulgular: Diz osteoartriti olan hastalarda, öznel uyku kalitesi, uykuya dalma süresi, alışılmış uyku etkinliği ve total PUKİ skoru kontrol grubuna göre anlamlı olarak yüksekti (p<0,05). Spearman analizi sonuçlarına göre, total PUKİ skoru ile yaş, yaygın ağrı, diz ağrısı, WOMAC ağrı, radyolojik evre ve depresif semptomlar arasında anlamlı korelasyonlar saptandı (p<0,05). Sonuç: Diz OA tanılı hastalarda uyku kalitesi bozulmaktadır. Bozulmuş uyku kalitesi özellikle diz ağrısı, yaş, depresif semptomlar ve radyolojik evre ile ilişkilidir.
Duloxetine-Induced Retrograde Ejaculation: A Case Report
(Kure Iletisim Grubu A S, 2015) Bulut, Mahmut; Gozukara, Keremhan; Kaya, Mehmet Cemal
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