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    Association Between the Rh Blood Group and the Covid-19 Susceptibility
    (Akad Doktorlar Yayinevi, 2020) Arac, Esref; Solmaz, Ihsan; Akkoc, Hasan; Donmezdil, Suleyman; Karahan, Zulkuf; Kaya, Safak; Mertsoy, Yilmaz
    We aimed to investigate whether there is a predisposition to COVID-19 with ABO and Rh blood group systems. This study was a retrospective study that investigate the patients admitted to our hospital between March 16 -May 20 due to Covid-19 pandemic and conducted with data revealed from the hospital Information Management System A total of 392 patients were included in this study, including 227 PCR test positive patients with blood group information in the system and 165 possible patients with CT findings in favor of Covid-19. Data from a blood group study conducted with 127091 people in our province in 2019 were used as a control group. In our study, a significant increase was observed in the blood group A in patients diagnosed with Covid-19, and a decrease was found in the blood groups B, AB and especially O. However, statistical analysis showed no significant difference between Covid-19 patients and healthy individuals in terms of ABO blood group system. When analyzed in terms of Rh blood group system, it was found that Rh positivity was statistically significantly higher in patients with Covid-19 (p= 0.000). Our study suggests that the Rh (-) blood group is protective and the Rh (+) blood group is predisposed to Covid 19 significantly. We think that it is valuable because it is the first study to reveal the relationship between Covid-19 and blood type in our country and the only one to reveal the relationship between Covid-19 and Rh (+) in the world literature.
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    Cardiac hydatid cyst in the interventricular septum leading to symptoms of subaortic stenosis: a case report
    (Turkish Soc Cardiology, 2007) Karadede, Aziz; Alyan, Omer; Karahan, Zulkuf
    A 44-year-old man presented with a complaint of dyspnea on exertion. Transthoracic two-dimensional echocardiography showed a cystic lesion in the basal region of the interventricular septum, 4.5x8 cm in size, suggesting a hydatid cyst. Color Doppler echocardiography demonstrated turbulent flow and mild aortic and mitral insufficiency. An indirect hemagglutination test yielded a positive result. The patient refused surgical treatment. A month later, it was found that he had died during surgery for the hydatid cyst at another center.
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    Coexisting subarachnoid hemorrhage and subdural hematoma mimicking acute anterolateral myocardial infarction
    (Churchill Livingstone Inc Medical Publishers, 2007) Iltumur, Kenan; Tamam, Yusuf; Karahan, Zulkuf; Guzel, Aslan; Altindag, Rojhat
    Ischemic electrocardiographic changes, elevations in cardiac-specific markers such as troponin and creatinine phosphokinase NIB, segmental wall motion abnormalities, and myocardial dysfunction may occur after central nervous system events such as subarachnoid hemorrhage, subdural hematoma, and ischemic stroke. The pathophysiology remains unclear, but a catecholamine-induced neurocardiogenic injury has been mentioned as a causative factor. We reported a case of coexisting subarachnoid hemorrhage and subdural hematoma with ischemic electrocardiography changes, increases in cardiac-specific enzymes, and a regional wall motion abnormality despite normal epicardial coronary arteries. It is very important to differentiate neurogenic stunned myocardium from myocardial dysfunction caused by coronary artery disease in patients with intracranial hemorrhages for appropriately managing the treatment of cases. (c) 2007 Elsevier Inc. All rights reserved.
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    High levels of high-sensitivity C-reactive protein and impaired autonomic activity in smokers
    (Turkish Soc Cardiology, 2008) Alyan, Omer; Kacmaz, Fehmi; Ozdemir, Ozcan; Karahan, Zulkuf; Taskesen, Tuncay; Iyem, Hikmet; Alan, Sait
    Objectives: We investigated the relationship between high sensitivity C-reactive protein (hs-CRP) activity and autonomic nervous activity using heart rate variability in smokers. Study design: The study consisted of 136 healthy subjects, including 66 smokers (35 women, 31 men; mean age 36 years) and 70 nonsmokers (43 women, 27 men; mean age 34 years). Serum samples were collected from all the subjects. Three-channel, 24-hr Holter monitoring was performed to derive the mean heart rate, standard deviation of normal NN intervals (SDNN), standard deviation of 5-minute mean NN intervals (SDANN), root mean square differences of successive NN intervals (RMSSD), high-(HF) and low-(LF) frequency power components, and the LF/HF ratio. Results: In smokers, the mean duration of smoking was 13.6 +/- 8.2 years (range 3 to 45 years), and the mean number of cigarettes consumed per day was 16.3 +/- 7.1 (range 5 to 40). Smokers exhibited significantly higher mean heart rate, hs-CRP and fibrinogen levels, mean platelet volume, white blood cell count, LF, and LF/HF ratio, with significantly lower SDNN, SDANN, RMSSD, and HF values. In smokers, hs-CRP was correlated with the number of cigarettes consumed per day, duration of smoking, fibrinogen level, mean platelet volume, white blood cell count, LF, and LF/HF ratio, and inversely correlated with HF, SDNN, and SDANN. Even smoking a single cigarette resulted in an acute, 0.07-fold increase in the hs-CRP level (p< 0.0001). In linear regression analysis, both the number of cigarettes consumed per day (beta= 0.52, p= 0.011) and duration of smoking (beta= 0.073, p< 0.0001) had an independent effect on the hs-CRP level. Conclusion: Smoking both impairs the sympathovagal balance and increases the hs-CRP activity in otherwise healthy smokers, the combination of which would probably contribute to a higher rate of cardiovascular events.
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    Pulmonary hypertension in patients with essential thrombocythemia and reactive thrombocytosis
    (Taylor & Francis Ltd, 2007) Altintas, Abdullah; Karahan, Zulkuf; Pasa, Semir; Cil, Timucin; Boyraz, Taylan; Iltumur, Kenan; Ayyildiz, Orhan
    Increased incidence of pulmonary hypertension ( PH) has been reported in patients with chronic myeloproliferative disorders. The exact incidence of PH in essential thrombocythemia ( ET) is unknown. Most of the reported literature consists of case reports or small studies. We designed this study to asses the incidence of PH in patients with ET and reactive thrombocytosis. Previously or newly diagnosed 46 patients with ET, and 40 patients with reactive thrombocytosis secondary to iron deficiency anemia were found to be eligible for this study. Diagnosis of PH was established via transthoracic echocardiography. PH was found in 22 ( 47.8%) out of 46 patients with ET. Seven patients with PH were newly diagnosed ET, 5 patients with PH were in low, and the other patients with PH were in intermediate or high risk category. We found statistically significant difference in terms of platelet counts between ET patients with PH and without PH ( p = 0.027). None of the patients with reactive thrombocytosis had PH. In conclusion, PH appears to be common in patients with ET. Therefore, all patients with ET should be evaluated for PH. Larger and prospective studies are required to clarify the long-term impact of PH on the survival of these patients. Future studies are also needed to determine whether cytoreductive treatment and aspirin prevent the development of PH, and to determine the effects of cytoreductive treatments and aspirin on the prognosis of PH. The effect of PH on ET prognosis should also be determined in low risk ET patients.