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Öğe The evaluation of the factors that affects the smoking behaviours in a group of high school students in Turkey(European Respiratory Soc Journals Ltd, 2015) Demir, Melike; Karadeniz, Gulistan; Demir, Fikri; Karadeniz, Cem; Kaya, Halide; Yenibertiz, Derya; Aylan, Mahsuk T.[Abstract Not Available]Öğe EVALUATION OF TPEAK-TEND INTERVAL AND TPEAK-END/QT RATIO IN PATIENTS WITH SARCOIDOSIS(Mattioli 1885, 2016) Ucsular, Fatma; Karadeniz, Gulistan; Karadeniz, Cem; Yalniz, Enver; Demir, MelikeBackground: Tp-e interval which represents the interval between the peak and the end of the T-wave on electrocardiogram (ECG), can be used as a marker of transmural dispersion of repolarization. Also, Tp-e/QT and Tp-e/QTc ratios are used as an index of arrhythmogenesis. Prolonged Tp-e interval and Tp-e/QT ratio was found associated with sudden cardiac death in different clinical conditions. Novel ventricular repolarization parameters, Tp-e interval, Tp-e/QT and Tp-e/QTc ratios have not been evaluated in patients with sarcoidosis without cardiac symptoms previously. Therefore, we investigated Tp-e interval in patients with pulmonary sarcoidosis. Methods: Sixty-one consecutive patients diagnosed with biopsy-proven pulmonary sarcoidosis were retrospectively reviewed. The 12-lead ECG examinations were performed at speed of 25 mm/s while the patients were in supine position. QT dispersion, Tp-e intervals and Tp-e/QT ratio were measured. Results: Comparison of ECG parameters between two groups showed a significantly higher average heart rate (p<0.05) in the patients with sarcoidosis than controls. QT dispersion was higher in patients group. Tp-e interval was significantly prolonged in the study group compared to the control group (92+/-21 ms and 85+/-14 ms, respectively; p<0.05). Tp-e/QT and Tp-e/QTc ratios were significantly higher in patients with sarcoidosis compared to control subjects (all p values < 0.05). Conclusions: The novel repolarization parameters Tp-e interval, Tp-e/QT and Tp-e/QTc ratios are increased in patients with sarcoidosis without any cardiac symptoms. These parameters might be used as a marker for predicting the ventricular arrhythmias and sudden cardiac death in patients with sarcoidosis.Öğe Evaluation of ventricular arrhythmogenesis in patients with sarcoidosis(European Respiratory Soc Journals Ltd, 2015) Ucsular, Fatma; Karadeniz, Gulistan; Karadeniz, Cem; Yalniz, Enver; Demir, Melike[Abstract Not Available]Öğe The impact of anti-smoking laws on high school students in Ankara, Turkey(Soc Brasileira Pneumologia Tisiologia, 2015) Demir, Melike; Karadeniz, Gulistan; Demir, Fikri; Karadeniz, Cem; Kaya, Halide; Yenibertiz, Derya; Taylan, Mahsuk[Abstract Not Available]Öğe Usefulness of neutrophil to lymphocyte ratio in prediction of coronary artery lesions in patients with Kawasaki disease(Aves Yayıncılık, 2015) Demir, Fikri; Karadeniz, Cem; Özdemir, Rahmi; Yozgat, Yılmaz; Çelegen, Kübra; Karaaslan, Utku; Demirol, MustafaBackground: Kawasaki disease is an inflammatory condition. Neutrophil to lymphocyte ratio is a marker reflecting inflammation. Aims: The aim of the study is to evaluate usefulness of neutrophil to lymphocyte ratio in diagnosis of Kawasaki disease and in prediction of coronary artery lesions. Study Design: Retrospective cross-sectional study. Methods: Seventy-five children with Kawasaki disease and 66 controls were retrospectively enrolled. Their leukocyte, neutrophil, and lymphocyte counts were recorded. Abnormally distributed data were shown as median (interquartile range). Cases having coronary artery diameter two standard deviation above mean were diagnosed to have coronary artery lesions. Results: Median age of Kawasaki disease patients was 34 months. Twentyfive of those (33.33%) had incomplete Kawasaki disease and twenty-six (34.66%) had coronary artery lesions. Leukocyte [12.61 (6.09)x103 / µL vs. 8.48 (5.58)x103 /µL], neutrophil [6.73 (4.10) x103 /µL vs. 4.62 (5.47)x103 /µL], and lymphocyte [4.04 (2.91)x103 /µL vs. 3.02 (2.57)x103 /µL] counts were significantly higher in Kawasaki disease patients compared to controls (all p values <0.01). However, there was not significant difference between patients and controls regarding neutrophil to lymphocyte ratio [1.72 (1.22) vs. 1.71 (1.88)]. Findings of Kawasaki disease and incomplete Kawasaki disease cases did not differ, while comparison of patients with and without coronary artery lesions revealed significantly higher neutrophil to lymphocyte ratio values in former group [2.02 (1.63) vs. 1.50 (1.28), p=0.01]. The cut-off neutrophil to lymphocyte ratio value for prediction of coronary artery lesions was determined as 1.32. Conclusion: Neutrophil to lymphocyte ratio values in Kawasaki patients with coronary lesions were significantly higher than the ones without and values greater than 1.32 were useful in prediction of coronary lesions.
