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    Decreased Serum Sulphydryl Levels as a Sign of Increased Oxidative Stress in Generalized Anxiety Disorder
    (Korean Neuropsychiatric Assoc, 2013) Kaya, Mehmet Cemal; Bez, Yasin; Karababa, Ibrahim Fatih; Emhan, Ali; Aksoy, Nurten; Bulut, Mahmut; Gunes, Mehmet
    Objective In recent years, many published studies have focused on the relationship between oxidative stress and psychiatric disorders. However, studies in generalized anxiety disorder (GAD) are few despite relatively high prevalence rates. In an attempt to fill this gap in the literature we aimed to measure serum levels of free sulphydryl, an important member of antioxidant defense mechanisms, of the patients with GAD. Methods A total of 35 (23 female, 12 male) GAD patients without any other co-morbid medical or psychiatric disorder and 35 (23 female, 12 male) healthy controls have been included in the study. Disease severity of the patients were quantified by using the Hamilton Anxiety Rating Scale (HAM-A). Serum free sulphydryl group levels of patients and healthy controls were measured in an appropriate way. Results Mean level of serum sulphydryl groups was significantly lower in the patient group. There was a negative correlation between their level and the disease duration. However, they did not show any significant correlation with the disease severity. Conclusion Decreased serum sulphydryl level observed in pure GAD patients suggests an increased oxidative stress in these patients. Well designed future researches are needed to replicate our findings and to test the implications of the present study.
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    MicroRNA dysregulation in manic and euthymic patients with bipolar disorder
    (Elsevier, 2020) Camkurt, Mehmet Akif; Karababa, Ibrahim Fatih; Erdal, Mehmet Emin; Kandemir, Sultan Basmaci; Fries, Gabriel R.; Bayazit, Huseyin; Ay, Mustafa Ertan
    Background: Bipolar disorder (BPD) is a major psychiatric disorder with an unclear pathophysiology. Peripheral blood samples are easily drawn, making them are good candidates for diagnosing diseases. MicroRNAs are small non-coding RNA transcripts that regulate gene expression by binding to the 3'-UTR of mRNAs and directing their degradation. The aim of this study was to use blood plasma to investigate microRNA dysregulations in bipolar manic and euthymic patients. Subjects and Methods: Blood samples were collected from 58 patients with bipolar I disorder (19 manic, 39 euthymic) and 51 healthy controls. Results: Four microRNAs (miR-29a-3p, p= 0.035; miR-106b-5p, p= 0.014; miR-107, p= 0.011; and miR-125a-3p, p= 0.014) were upregulated in the entire bipolar group, compared to the healthy controls. Seven microRNAs (miR-9-5p, p= 0.032; miR-29a-3p, p= 0.001; miR-106a-5p, p= 0.034; miR-106b-5p, p= 0.003; miR-107, p< 0.001; miR-125a-3p, p= 0.016; and miR-125b-5p, p= 0.004) were more upregulated in bipolar manic patients compared to the healthy controls, and two microRNAs (miR-106a-5p, p= 0.013, and miR-107, p= 0.021) showed statistically significant upregulation in the manic patients compared to the euthymic patients. Conclusions: Our results showed greater miRNA dysregulation in the manic patients than in the euthymic patients. Two microRNAs could be more selective for bipolar manic episodes. Future studies should include depressive patients along with euthymic and manic patients.
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    No Effect of Antidepressant Treatment on Elevated Serum Ceruloplasmin Level in Patients with First-Episode Depression: A Longitidunal Study
    (Elsevier Science Inc, 2012) Kaya, Mehmet Cemal; Bez, Yasin; Selek, Salih; Karababa, Ibrahim Fatih; Bulut, Mahmut; Savas, Haluk A.; Celik, Hakim
    Background and Aims. Ceruloplasmin, an acute phase reactant with antioxidant capacity, has been found to be increased in some psychiatric disorders like schizophrenia and obsessive compulsive disorder. However, studies in depression are very scarce. We under-took this study determine the serum ceruloplasmin levels of depressive patients before and after treatment, to compare them with those of healthy control subjects, and to assess any possible association of ceruloplasmin and treatment response. Methods. Nineteen (8 male, 11 female) patients with major depressive disorder and 40 (17 male, 23 female) healthy control subjects were included in the study. The patients received naturalistic antidepressant treatment for 8 weeks after diagnosis. Serum ceruloplasmin levels and Hamilton Depression Rating Scale (HAM-D) scores of the patients were measured before and after their antidepressant treatment. Blood collection for ceruloplasmin measurement was done only once for healthy control subjects. Results. Patients' ceruloplasmin levels before and after antidepressant treatment were significantly higher than control subjects (t = 7.569, p < 0.001 and t = 6.764, p < 0.001, respectively). Despite clinical improvement, ceruloplasmin did not show any significant change after treatment in patients with depression (t = -1.163, p = 0.260) and remained higher than levels of control subjects. No correlation was found between HAM-D score, presence of response, and ceruloplasmin levels. Conclusions. Compared to healthy control subjects, ceruloplasmin level seemed to be higher in patients with depression and remained high, despite acute antidepressant treatment. Improvement in clinical measurements of depression after antidepressant treatment was not reflected as significant alterations in serum ceruloplasmin levels. (C) 2012 IMSS. Published by Elsevier Inc.
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    Reduced PON1 enzymatic activity and increased lipid hydroperoxide levels that point out oxidative stress in generalized anxiety disorder
    (Elsevier, 2013) Bulut, Mahmut; Selek, Salih; Bez, Yasin; Karababa, Ibrahim Fatih; Kaya, Mehmet Cemal; Gunes, Mehmet; Emhan, Ali
    In recent years, there has been an increasing focus on generalized anxiety disorder (GAD) which is one of the most prevalent mental disorders in general population. Psychological, genetic, neurobiological, and neurochemical factors are believed to play role in the etiopathogenesis of GAD. The role of oxidative stress, as a neurochemical cause, in various anxiety disorders has been studied in recent years; however, it has not been thoroughly studied in GAD, yet. In this paper, we aimed to evaluate the serum levels of lipid hydroperoxide (LOOH), paraoxonase, and arylesterase in GAD patients without any co-morbid psychiatric disorders and investigate their diagnostic performance. Blood samples were collected from 40 GAD patients and 40 healthy control subjects to measure their serum LOON levels, arylesterase and paraoxonase activities. Obtained results have been compared between groups and receiver operating characteristic (ROC) curve has been drawn for diagnostic performance of measured biochemical markers. Positive and negative predictive values have been estimated where appropriate. Mean LOOH level of the GAD patients was significantly higher than that of control subjects (t=-549, p<0.001), whereas, mean paraoxonase activity was lower in these patients (t=3.056, p=003), GAD could be predicted for LOON level over 7.740 mu mol/l with 92.5% positive predictive value and 92% negative predictive value. Increased LOON level and decreased paraoxonase activity of GAD patients may suggest increased lipid peroxidation and oxidative stress in these patients. LOON levels may be a state marker for diagnosing GAD. (C) 2013 Elsevier B.V. All rights reserved.
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    Retrospective evaluation of 30,000 patients admitted to a psychiatry clinic of a state hospital in Turkey
    (E-Century Publishing Corp, 2016) Asoglu, Mehmet; Fedai, Ulker; Celik, Hakim; Karababa, Ibrahim Fatih; Kati, Mahmut; Kivrak, Yuksel; Nebioglu, Melike
    Aim: Epidemiological studies are needed to maintain clues about etiology and pathogenesis of psychiatric disorders and to determine the risk groups. In this study, it was aimed to determine the prevalence of psychiatric disorders, divergence according to age and gender among 30000 patients. Methods: This study population included 30000 patients that had admitted to psychiatry clinic of Sanliurfa Balikligol State Hospital between 2008 and 2012. Patients were evaluated about prevalence of psychiatric disorders, divergence according to age and gender and their relationship statistically. Results: The most prevalent psychiatric disorder was anxiety disorder with 52.8%. The other prevalent disorders were as followed; mood disorders 30.1%, dissociative disorders 7.3%, schizophrenia and other psychotic disorders 4.4%. Discussion: The results of this descriptive study will be useful for comparing the regional factors with the studies that will be done in different regions. In order to achieve more accurate data about determination of risk factors for psychiatric disorders, studies with comprehensive sociodemographic properties are needed to be done.