Yazar "Kaplan, Abdurahman" seçeneğine göre listele

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    Evaluation of CA 72-4 as a new tumor marker in patients with gastric cancer
    (H G E Update Medical Publishing S A, 2007) Goral, Vedat; Yesilbagdan, Haluk; Kaplan, Abdurahman; Site, Dede
    Background/Aims: The place of CA 72-4, a new tumor marker in the prognosis of stomach cancer were studied. Methodology: Endoscopically and histologically diagnosed 47 gastric patients were studied. CEA, CA 19-9, CA 125, CA 15-3, CA 72-4 levels were measured. Results: We determined that serum CA 72-4 level in the group with cancer was significantly elevated. In patients particularly having liver metastases, CA 724 level was found to be greater. Conclusions: We are of the opinion that serum CA 72-4 level is a valuable parameter in the prognosis of stomach cancer.
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    Plasma cytokine levels in ulcerative colitis
    (H G E Update Medical Publishing S A, 2007) Goral, Vedat; Celenk, Tahir; Kaplan, Abdurahman; Sit, Dede
    Background/Aims: Some immunological factors are responsible in the pathogenesis of ulcerative colitis. There is a relationship between cytokines and ulcerative colitis. Methodology: In this study 20 ulcerative colitis patients (mean age 36.2 years old, 9 women, 11 men) and 20 healthy control groups (mean age 27.2 years old, 11 women, 9 men) were involved in the study. Results: We established that IL-2Rsp, IL-6, IL-8 and IL-10 levels were different at the patients and control groups (p < 0.005). TNF-alpha and IL-1 beta were similar at the both groups. Conclusions: According to these results, IL-2Rsp, IL-6, II-8 and IL-10 play an important role in the pathogenesis of ulcerative colitis. We consider that these cytokines are beneficial parameters in the diagnosis, treatment and prognosis of ulcerative colitis.
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    Plasma resistin and leptin levels in overweight and lean patients with rheumatoid arthritis
    (Tubitak Scientific & Technological Research Council Turkey, 2009) Canoruc, Naime; Kale, Ebru; Turhanoglu, Ayse Dicle; Ozmen, Sehmus; Ogun, Ceyla; Kaplan, Abdurahman
    Aim: Adipocytokines; are now considered important players in the etiopathogenesis of numerous metabolic and inflammatory disorders. However, plasma leptin and resistin levels in rheumatoid arthritis (RA) are still unclear. We aimed to investigate the plasma levels of leptin and resistin in patients with rheumatoid arthritis and to compare them with controls. Materials and Methods: Consecutive 52 patients with RA were compared with 52 control subjects in terms of mean leptin and resistin levels. Results: Patients with RA showed considerably higher plasma levels of leptin (34.3 +/- 27.9 vs. 11.1 +/- 4.1) and resistin (4.8 +/- 0.7 vs. 4.0 +/- 1.3) than healthy controls (P < 0.0001). There was no significant difference regarding age, duration of disease, sex, CRP, and leptin and resistin levels between overweight and lean RA Subjects. Plasma leptin level was significantly correlated with ESR (Erythrocyte Sedimentation Rate) (r = 0.287, P = 0.039) and swollen and tender joint count (r = 0.563, P < 0.0001) but not with resistin in subjects with RA. Measuring the plasma leptin level may be a potential marker of disease activity in RA. Conclusions: Studies including more RA patients might be needed to define the role of leptin and resistin in RA subjects.
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    The Relation Between Pathogenesis of Liver Cirrhosis, Hepatic Encephalopathy and Serum Cytokine Levels: What is the Role of Tumor Necrosis Factor Alpha?
    (H G E Update Medical Publishing S A, 2011) Goral, Vedat; Atayan, Yahya; Kaplan, Abdurahman
    Background/Aims: Hepatic encephalopathy (HE) is a major complication of acute or chronic liver disease characterized by neuropsychiatric symptoms. It's etiology and pathogenetical mechanisms are not clearly understood and probably it is multifactorial. In this study, we aimed to investigate the relation between pathogenesis of HE and TNF-alpha, IL-1 beta, IL-2R, IL-6, IL-8 and IL-10, and between the severity of HE and the levels of these cytokines. Methodology: Eighty patients with liver cirrhosis [50 patients with clinical findings of HE (group 1) and 30 without any symptoms of HE (group 2)] and 30 healthy controls (group 3) were included into the study. Serum TNF-alpha, IL-1 beta, IL-2R, IL-6, IL-8 and IL-10 levels of patients and control subjects were studied with the chemiluminescent method. Results: There were statistically significant difference between serum TNF-alpha, IL-1 beta, IL-2R, IL-6 and IL-8 levels of patients with liver cirrhosis and healthy subjects (p<0.05), and between patients with and without HE (p<0.05). There was a correlation between the severity of liver cirrhosis according to Child-Pugh classification and cytokine levels. The severity of HE (grade 1-4) was closely related with cytokine levels, especially TNF-alpha. On the other hand, there was no relation between cytokine levels and the etiological factors. Conclusion: We found a positive correlation between serum inflammatory cytokine levels (TNF-alpha, IL-1 beta, IL-2R, IL-6, IL-8) and the severity of liver cirrhosis. In addition, our findings suggested that this relation is independent from etiological factors.