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Öğe Characterization of an extracellular ?-galactosidase produced by thermophilic Bacillus licheniformis KG9 isolated from hot spring in Batman-Turkey(Wiley-Blackwell Publishing, Inc, 2010) Kaplan, A.; Guven, R. Gul; Bekler, F. Matpan; Acer, O.; Guven, K.[Abstract Not Available]Öğe The effect of periodontal therapy on serum TNF-? and HbA1c levels in type 2 diabetic patients(Wiley, 2009) Dag, A.; Firat, E. T.; Arikan, S.; Kadiroglu, A. K.; Kaplan, A.Background: To determine the effect of non-surgical periodontal therapy on serum TNF-alpha and HbA1c levels in poorly and well-controlled type 2 diabetic patients. Methods: In total, 45 patients were enrolled in the study; 30 patients with type 2 diabetes mellitus with periodontitis (15 with poorly controlled diabetes, HbA1c >= 7%, group 1A and 15 with well-controlled diabetes, HbA1c < 7%, group 1B) and 15 patients that were systemically healthy with periodontitis (group 2). The plaque index, gingival index, probing depth, clinical attachment loss, gingival bleeding index, HbA1c value, and circulating TNF-alpha concentration were measured at baseline and three months after the non-surgical periodontal therapy. Results: All periodontal parameters and serum TNF-alpha levels were significantly decreased three months after the nonsurgical periodontal therapy compared to the baseline values in all groups. The HbA1c values were significantly decreased only in well-controlled diabetic patients. We found no significant differences in the periodontal parameters or TNF-alpha levels at baseline and after three months between the two groups. Conclusions: Although non-surgical periodontal therapy eliminates local/systemic infection and inflammation via decreases in TNF-alpha, it is insufficient for significantly reducing HbA1c levels without strict glycaemic control in poorly controlled diabetic patients in a short time period.Öğe Effect of various starches on production of ?-amylase in thermophilic Bacillus licheniformis(Blackwell Publishing, 2008) Matpan, F.; Ozdemir, S.; Gul-Guven, R.; Kaplan, A.; Pirinccioglu, H.; Guven, K.[Abstract Not Available]Öğe Effects of various inhibitors on ?-Amylase in Anoxybacillus sp. AH1 isolated from hotspring(Wiley-Blackwell Publishing, Inc, 2010) Acer, O.; Bekler, F. Matpan; Guven, R. Gul; Pirinccioglu, H.; Kaplan, A.; Guven, K.[Abstract Not Available]Öğe The effects of various inhibitors on ?-galactosidase purified from the thermoacidophilic Alicyclobacillus acidocaldarius subsp rittmannii isolated from Antarctica(Blackwell Publishing, 2008) Guven, K.; Kaplan, A.; Gul-Guven, R.; Matpan, F.; Dogru, M.[Abstract Not Available]Öğe EFFICACY OF ADJUVANT 9-WEEKS TRASTUZUMAB IN NODE-NEGATIVE T1A/B HER2-POSITIVE BREAST CANCER(Oxford Univ Press, 2014) Sendur, M. A.; Aksoy, S.; Uncu, D.; Demir, H.; Yuksel, S.; Ekinci, A. S.; Kaplan, A.[Abstract Not Available]Öğe Elevated amniotic fluid amino acid levels in fetuses with gastroschisis(Blackwell Publishing, 2006) Kaplan, A.; Kale, A.; Kale, E.; Akdeniz, N.; Canoruc, N.[Abstract Not Available]Öğe Obstructive sleep apnoea, cigarette smoking and serum testosterone levels in a male sleep clinic cohort(Sage Publications Ltd, 2007) Kirbas, G.; Abakay, A.; Topcu, F.; Kaplan, A.; Unlu, M.; Peker, Y.This study evaluated the impact of obstructive sleep apnoea (OSA) and smoking on total serum testosterone levels in 96 men (mean age 43.3 years; range 25 - 60 years) attending a sleep clinic. Fifty-five men (57.3%) had OSA, defined as an apnoea-hypopnoea index of 2: 15 events/h, recorded during overnight polysomnography, and 42 (43.8%) were current smokers. Mean serum total testosterone levels were significantly lower in OSA subjects (3.4 ng/ml) than in non-OSA subjects (3.9 ng/ml), whereas no significant difference was observed between current smokers and nonsmokers. In a multiple linear regression analysis, serum testosterone was negatively correlated with body mass index and the apnoea-hypopnoea index, but not with age and pack-years of smoking. Our results support previous observations regarding testosterone levels in men with OSA, but, contrary to some earlier reports, there was no positive relationship between smoking and total testosterone in the present cohort.Öğe Replacement of hystological findings(Wiley, 2007) Yilmaz, S.; Bayan, K.; Tuezuen, Y.; Dursun, M.; Kaplan, A.; Oezmen, S.; Canoruc, F.Because of limitations in biopsy procedure, several non-invasive tests have been developed for predicting the histological findings in chronic hepatitis. A fibrosis (F) score 1 or above and necroinflammation [histological activity index (HAI)] score 4 or above are required to initiate the treatment in chronic viral hepatitis. Literature includes many studies on hyaluronic acid (HA) as a non-invasive procedure in predicting histological findings but lacks on high-sensitive-C-reactive protein (hsCRP). We evaluated the diagnostic value of HA and hsCRP in patients with chronic viral hepatitis. Ninety-eight subjects (42 chronic viral hepatitis, 28 cirrhosis and 28 healthy controls) were included in the study. Liver biopsies were performed on 42 chronic hepatitis patients and assessed by Ishak scoring system. All sera were stored at -70 degrees C until assay. Many laboratory parameters related to viral hepatitis, HA and hsCRP were studied following the instructions. We tried to determine a cut-off value for HA to represent >= F1 score and that for hsCRP to represent >= 4 HAI score. Hepatitis B virus was the predominant aetiology of chronic hepatitis in our study. Mean HA levels were 113, 754 and 24 ng/ml in patients with chronic hepatitis, cirrhosis and controls, respectively (ANOVA, p < 0.001). A HA level > 64.7 ng/ml had a 100% specificity for diagnosing chronic hepatitis. A value >= 154 ng/ml had a 100% specificity, 100% positive predictive value and 90% negative predictive value for diagnosing liver cirrhosis (Area 1.00; p < 0.0001). A cut-off value of 63 ng/ml for HA had a 100% specificity for diagnosing fibrosis score >= 1 in chronic hepatitis (Area 0.86; p < 0.001). An hsCRP level > 0.56 mg/dl had a 100% specificity and 12% sensitivity for diagnosing chronic hepatitis (Area 0.71; p = 0.002), while cut-off of 0.53 mg/dl had 75% specificity for diagnosing HAI >= 4 in chronic hepatitis (Area 0.32; p = 0.132). This study supported the HA level in predicting fibrosis score >= 1 with a cut-off value of 63 ng/ml. Cut-off of 154 ng/ml had a strong worth for cirrhosis. A cut-off of hsCRP for predicting HAI score >= 4 warrants further evaluation in wider study populations. We concluded that we are a bit closer to the strategy for guiding therapy in patients with chronic hepatitis, without a liver biopsy.Öğe Screening survey of beta thalassemia carriers in Diyarbakir province(Blackwell Publishing, 2006) Ekinci, S.; Erdinc, L.; Gunes, K.; Batun, S.; Kaplan, A.; Kale, E.; Canoruc, N.[Abstract Not Available]Öğe Serum IL-2R, IL-6, Ig G, Ig G subgroups (IgG 1, 2, 3, 4) levels in iron deficiency anemia and ?-thalassemia carriers(Blackwell Publishing, 2006) Demir, M.; Canoruc, N.; Batun, S.; Kale, E.; Erdinc, L.; Kaplan, A.[Abstract Not Available]
