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    Investigation of the arterial intima-media thickness in Behcet's disease patients without vascular complaints
    (Sage Publications Ltd, 2018) Kankilic, Nazim; Aslan, Aydin; Karahan, Oguz; Demirtas, Sinan; Caliskan, Ahmet; Yavuz, Celal
    Objectives Behcet's disease is a multisystemic, inflammatory disease. Various factors have been implicated in the disease, including genetics, infections, immunoglobulins, immune complexes, antibodies, and oxidative stress. However, the underlying etiopathogenesis remains unclear. Behcet's disease can occur with or without vascular involvement. This prospective study investigated the relationship between the intima-media thickness of the major arteries, in addition to other factors affecting the disease process, in Behcet's disease without vascular involvement. Methods Twenty-four patients (average age: 38.5010.931) without vascular involvement or any vascular complaints who were diagnosed with Behcet's disease were included in the study. Sixteen healthy subjects (average age: 39.757.793) were included as a control group. Demographic information and medical histories were recorded, and routine blood tests were performed in both groups. The intima-media thickness of the subclavian, axillary, femoral, and carotid arteries of all the participants were recorded using Doppler ultrasonography. The data were then subjected to intergroup statistical and correlation analyses. Results There were no significant differences between the arterial intima-media thickness values of the Behcet's disease patients and those of the control group (p>0.05). However, there was a significant difference between the neutrophil-lymphocyte ratio (p=0.004), low-density lipoprotein (p=0.007), and triglyceride (p=0042) levels of the two groups. Significant correlations were found between intima-media thickness and neutrophil-lymphocyte ratio levels (p=0.012) and the disease duration (p=0.030). There was also a significant correlation between the intima-media thickness of the femoral artery and disease duration (p=0.014). Conclusions The results showed that the duration of illness had a significant effect on arterial intima-media thickness in Behcet's disease. Blood neutrophil-lymphocyte ratio levels were also associated with increased intima-media thickness.
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    Simple blood tests as predictive markers of disease severity and clinical condition in patients with venous insufficiency
    (Lippincott Williams & Wilkins, 2016) Karahan, Oguz; Yavuz, Celal; Kankilic, Nazim; Demirtas, Sinan; Tezcan, Orhan; Caliskan, Ahmet; Mavitas, Binali
    Chronic venous insufficiency (CVI) is a progressive inflammatory disease. Because of its inflammatory nature, several circulating markers were investigated for predicting disease progression. We aimed to investigate simple inflammatory blood markers as predictors of clinical class and disease severity in patients with CVI. Eighty patients with CVI were divided into three groups according to clinical class (grade 1, 2 and 3) and score of disease severity (mild, moderate and severe). The basic inflammatory blood markers [ neutrophil, lymphocyte, mean platelet volume (MPV), white blood cell (WBC), platelet, albumin, D-dimer, fibrinogen, fibrinogen to albumin ratio, and neutrophil to lymphocyte ratio] were investigated in each group. Serum neutrophil, lymphocyte, MPV, platelet count, D-dimer and neutrophil to lymphocyte ratio levels were similar among the groups (P>0.05). Although the serum WBC levels were significant in the clinical severity groups (P<0.05), it was useless to separate each severity class. However, albumin, fibrinogen and the fibrinogen to albumin ratio were significant predictors of clinical class and disease severity. Especially, the fibrinogen to albumin ratio was detected as an independent indicator for a clinical class and disease severity with high sensitivity and specificity (75% sensitivity and 87.5% specificity for clinical class and 90% sensitivity and 88.3% specificity for disease severity). Serum fibrinogen and albumin levels can be useful parameters to determine clinical class and disease severity in patients with CVI. Moreover, the fibrinogen to albumin ratio is a more sensitive and specific predictor of the progression of CVI. Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved.