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Öğe MicroRNA Dysregulation in Bipolar Manic and Euthymic Patients(Elsevier Science Inc, 2019) Karababa, Fatih; Camkurt, Akif; Erdal, Mehmet; Kandemir, Sultan; Bayazit, Huseyin; Ay, Mustafa; Kandemir, Hasan[Abstract Not Available]Öğe Neutrophil-to-lymphocyte ratio and platelet distribution width: A potential new peripheral biomarker in adolescent depression(ANP Publishing, 2022) Öztürk, Masum; Özkan, Yekta; Sapmaz, Şermin Yalın; Kandemir, HasanObjective: The aim of this study is to evaluate the role of inflammation in the underlying pathophysiology of adolescent depression by evaluating neutrophile-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) and hemogram parameters and also to determine whether there is a relationship between depression severity and inflammatory parameters. Method: This retrospective study was carried out on 93 major depressive disorder (MDD) patients and 65 healthy control. Clinical features such as diagnosis date, diagnosis during admission to hospital using DSM-5 diagnostic criteria, comorbid physical and psychiatric illness, drug use, previous psychiatric diagnosis, history of suicide attempt were determined. In addition, hemogram parameters of the participant included in the study in the hospital data system were used. Results: NLR and platelet distribution width (PDW) were found to be statistically significantly higher in the patient group than in the control group (p<0.05). A weakly significant positive correlation (p=0.039, r=0.165) was found between NLR and depression severity scale; a positive correlation was found between PDW and depression scale scores and depression severity scale total scores (p<0.001, r=0.317; p<0.001, r=0.320, respectively). Discussion: NLR and PDW were found to be significantly higher in patients with MDD than in healthy controls, and it supports the possible role of lowgrade inflammation in the pathophysiology of MDD. In the next years, prospective studies in which hemogram parameters are evaluated together with proinflammatory cytokines will more clearly illuminate the role of inflammation and platelet activation in the etiology of MDD in adolescents.Öğe On a couple of nonlocal singular viscoelastic equations with damping and general source terms: Blow-up of solutions(Hindawi LTD, 2021) Pişkin, Erhan; Boulaaras, Salah Mahmoud; Kandemir, Hasan; Cherif, Bahri Belkacem; Biomy, MohamedUnder some given conditions, we prove the explosion result of the solution of the system of nonlocal singular viscoelastic with damping and source terms on general case. This current study is a general case of the previous work of Boulaaras.Öğe Tekil integral denklemlerin çözümlerinin patlaması(Dicle Üniversitesi, Fen Bilimleri Enstitüsü, 2021) Kandemir, Hasan; Pişkin, ErhanBu tezin ilk bölümünde diferansiyel denklemler ile ilgili bilgilendirme yapılmış ve temel düzeyde gerçekleşen çözümlerin patlaması ile ilgili bilgi verilmiştir. İkinci bölümde çözümlerin patlaması ile ilgili önceki çalışmalara yer verilmiştir. Üçüncü bölümde tez boyunca gerekli olabilecek temel tanımlar, lemmalar, teoremler, eşitsizlikler ve eşitlikler verilmiştir. Dördüncü bölüm ise üç kısımdan oluşmaktadır: İlk kısımda lokal olmayan, tekil viskoelastik denkleminin çözümlerinin patlaması Georgiev ve Todorova metodu ile; ikinci kısımda lokal olmayan, tekil viskoelastik denklem sisteminin çözümlerinin patlaması Li-Tsai metodu ile; üçüncü kısım ise tezin esas orijinal kısmını oluşturan lineer olmayan damping terimli, lokal olmayan, tekil viskoelastik denklem sisteminin çözümlerinin patlaması Georgiev ve Todorova metodu ile çalışılmıştır.Öğe Thiol/Disulfide Homeostasis: A Potential New Peripheral Biomarker in Adolescent Depression(AVES, 2024) Öztürk, Masum; Özkan, Yekta; Sapmaz, Şermin Yalın; Erdal, Serkan; Taneli, Fatma; Kandemir, HasanBackground: Thiol-disulfide homeostasis (TDH), one of the most important antioxidants, is involved in the non-enzymatic removal of reactive oxygen molecules in the body and is one of the many methods to measure the level of oxidative stress (OS). In the present study, TDH is investigated in adolescent depression, and its relationship to clinical variables is examined. Methods: Thirty-two (50.0%) patients diagnosed with major depressive disorder (MDD) and without psychotropic drug use and 32 (50.0%) healthy controls were included in the present study. The subjects MDD and control groups were between 13 and 18 years old. Participants completed the DSM-5 Level-2 scales for depression and irritability. A colorimetric method proposed by Erel and Neselioglu was used to analyze the TDH parameters of serum samples. Results: Biochemical analyses of samples from the MDD and control groups showed significant differences between the groups in native thiol (SH) levels (P =.002), disulfide (SS) levels (P =.021), disulfide/total thiol (SS/ToSH) (P =.009), and disulfide/native thiol (SS/SH) (P =.003) levels. Analysis of receiver operating characteristic showed that the area under the curve values with “acceptable discrimination potential” for the TDH parameters were significantly able to discriminate individuals with MDD from healthy controls. Conclusion: Thiol-disulfide homeostasis, one of the OS parameters, was found to be impaired in adolescents with depression. Our results suggest that TDH may contribute to the etiopathogenesis of adolescent MDD and that TDH may be a novel approach to assess OS in adolescent depression. © 2024, AVES. All rights reserved.Öğe YouTube as a source of information on the impact of the COVID-19 pandemic on mental health of children(Galenos Yayınevi, 2022) Öztürk, Masum; Özkan, Yekta; Sapmaz, Şermin Yalın; Kandemir, HasanObjectives: World Health Organization has announced that the coronavirus disease-2019 (COVID-19) outbreak is a pandemic that causes worry and panic in anyone who is exposed to the virus’s actual or imagined threat. Our lifestyles and life patterns have radically changed, and the impact of the COVID-19 epidemic has pervaded all areas of our daily lives. The aim of this research was to evaluate the quality of the most popular YouTubeTM videos about the effects of COVID-19 infection/pandemic status on children and adolescents. Materials and Methods: DISCERN tool and the Global Quality Scale were used to the reliability and quality of videos, respectively. The quality of the videos is classified into three groups as "poor quality", "moderate quality" and "good/ excellent quality". Results: A total of 112 videos were included in the study and these videos were evaluated by the researchers. Of the videos, 31.3% (n=35) were of good/excellent quality, 32.1% (n=36) were moderate, and 36.6% (n=41) were of poor quality. It was determined that the reliability of the good/excellent quality videos was statistically significantly higher than the moderate and poor-quality videos (p<0.001). Conclusion: Although YouTubeTM contains important health data, some of this information is false and consists of low-quality videos. Mental health professionals should direct patients to the correct internet information resources.
