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Öğe The effect of 900 MHZ radiofrequency (RF) radiation on some hormonal and biochemical parameters in rabbits(2009) Karadede B.; Akdag M.Z.; Kanay Z.; Bozbiyik A.In this study, the effect of cell phone frequency 900 MHz radiofrequency (RF) radiation on rabbits' some hormonal and biochemical parameters was investigated. 14 male, adult, New Zealand albino rabbits were separated into two groups as control and experimental (n=7). For the experimental group, rabbits exposed to 900 MHz frequency RF radiation 2 h per day (7 days in a week) for 90 days. Control group rabbits' procedure was the same as experimental group except the exposure of RF. Before the exposure, at first and third month of exposure; Glucose, Creatinin, Na, K, Cl, Calcium, Phosphorus, Total protein, Albumin, Globulin and Magnesium levels and T3, T4, TSH, LH, FSH, Testesteron, Estradiol, Prolactin, Cortisol, ACTH and Growth Hormon levels were determined from rabbits' blood which was taken from V.Marginalis in their right ear. There was not any significant difference in neither hormonal nor biochemical parameters between experimental and control groups before exposure (p>0.05). At first month of RF exposure; there was not any significant difference in biochemical parameters (p>0.05). However, T4, Testesterone, Estradiol, Cortisol and ACTH levels increased but this increasing was not stastistically significant (p>0.05). After third month exposure, it was found that there was not any significant difference in biochemical parameters (p>0.05), but there was an increase at T4, Cortisol and ACTH levels and only increasing in ACTH levels was stastistically significant (p<0.05). It was concluded that 900 MHz RF exposure did not change some important biochemical and hormonal parameters except ACTH levels after 90 days exposure.Öğe The effect of exogen glutathione administration on the gastric mucosal barrier in rats under stress(1998) Kanay Z.; Sert C.; Isik B.; Kurt D.; Guzel C.; Mete N.We investigated the effect of glutathione (GSH) on the gastric mucosal barrier of rats under stress. Twenty two swiss Albino rats weighing between 150-200 g were used and stress was induced by cold and immobilisation. GSH was administered in 300 mg/kg doses to the study group and oral saline was given to a control group. Mucus and phospholipid levels of the gastric mucosal barrier were then measured using come and Baur's methods. These important components of the gastric mucosal barrier were found to be decreased (p<0.05), but levels were higher in rats given GSH than in the control group (p<0.01, p<0.05 respectively). To conclude, GSH was found to be effective in preventing gastric mucosal barrier damage caused by stress.Öğe The effects of octreotide on gastric lesions and gastric mucosal barrier in rats which applied stress(1999) Guzel C.; Kanay Z.; Onen A.; Kurt D.; Denli O.; Canoruc F.The aim of this research was to investigate the effects of octreatide on gastric lesions and mucosal barrier in rats exposed cold +immobilisation stress. Twenty four Swiss Albino rats (approx 150-200 g) were used for this study. Feeds were witheld from to rats for 24 hours, after which they were divided in to three groups. Each group consisted of seven rats; I (n=7) non/stress-induced control group, 2 (n=7): cold and immobilisation stress was induced, 3 (n=7): 100 ?g/kg octreatide was administered subcutaneously one hour prior to stress induction. The rats were then killed and their stomachs examined for ulcerative lesions and ulcer indexes considered. The amounts of mucus and phospholipid, important components of the gastric mucosal barrier, were then rated using Corn and Baur methods and were found to be significantly decreased (p<0.05, p>0.05) in rats exposed to stress. In the third group given sandostatin, it was found that gastric lesions had been prevented. Moreover, mucus and phospholipid levels were higher in this group than the stress exposed control group. (p<0.05, p<0.05 respectively). According to our findings, octreatide is effective in preventing acute hemorrhagic gastric lesions caused by stress and in maintaining gastric mucosal barrier parameters.Öğe An Investigation of the Copper (Cu), Zinc (Zn) and Selenium (Se) Levels of Blood Serum and the Cu and Zn Levels of Wool of Akkaraman Ewes in the Diyarbakir Region(2001) Kurt D.; Denli O.; Kanay Z.; Güzel C.; Ceylan K.The aim of this study is to determine the copper, zinc and selenium levels of blood serum and the Cu and Zn levels of wool of healthy Akkaraman ewes grazed in the meadows in the Diyarbakir region. A total of 60 units of blood and wool samples from various villages in different counties of Diyarbakir (Bismil, Çinar, Ergani, Silvan, Kocaköy and some Diyarbakir villages) were studied. The Cu, Zn and Se levels of sera and the Cu and Zn levels of wool were analyzed by flameless atomic absorption spectrophotometer. We found significant differences in Cu and Se levels of sera, in Cu levels of wool (p<0.01) and in Zn levels of wool (p<0.05) in ewes from various counties, whereas no significant differences were observed in Zn levels of sera (p>0.05). Although there were considerable differences from county to county, the avarage values of these counties and herds that indicated the lowest values in respect to Cu and Zn contents were found to be either simillar to or just over the normal values. However, in the case of the selenium content, the average serum Se level of the Akkaraman ewes from various counties of Diyarbakir, except the central county, was found to be remarkably lower than the normal values. In the light of these findings, the rations of animals grazing in meadows are recommended to be reinforced with Se content.Öğe Protective effects of L-Arginine and pentoxifylline on mucosal barrier in ischemia-reperfusion induced gastric injury in rats(2003) Önen A.; Kanay Z.; Kurt D.Aim: To determine the effects L-Arginine (L-Arg) and pentoxifylline (Ptx) on mucosal barrier in ischemia-reperfusion (IR) induced gastric injury in rats. Method: Twenty-eight males, adult Wistar Albino rats (200-250 g) were used in the study. The rats were anesthetized by ketamine hydrokloride. Laparotomy only was applied in control group (n=7). In other three groups, coeliac artery was occluded for a period of 30 minutes followed by a reperfusion period of 60 minutes. No drug was given in IR group (n=7). In Ptx+IR group (n=7), 50 mg/kg Ptx was administered intraperitoneally before reperfusion. In L-Arg+IR group (n=7), 3 mg/kg/minute L-Arginine was increased immediately before refursion. The amounts of mucus and phospholipid were determined by Corne and Baur's methods. Ulcer index was measured via counting macroscopical petechial hemorrhage. Results: Mucus and phospholipid levels in gastric mucosa were significantly lower in IR group compared to control group (p<0.01). The amount of phospholipid was significantly higher in both Ptx+IR and L-Arg+IR groups when compared to those of IR group (p<0.01), while there were no significant differences between Ptx+IR and L-Arg+IR and IR group in terms of mucus amount (p>0.05). Phospholipid level was significantly higher in L-Arg+IR group when compared to Ptx+IR group (p<0.01), while there was no significant difference between these two groups from the point of mucus amount (p>0.05). Ulcer index was significantly higher in IR group than Ptx+IR and L-Arg+IR groups (p<0.05, p<0.01). Conclusion: Gastric IR breaks mucosal barrier through significantly decreased mucus and phospholipid levels and results in gastric mucosal damage via increased ulcer index. Ptx and L-Arg diminish barrier breakage and mucosal damage induced by IR. L-Arg seems to protect the gastric mucosal barrier better than Ptx does.
