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    Combining platelet rich fibrin with different bone graft materials: An experimental study on the histopathological and immunohistochemical aspects of bone healing
    (Churchill Livingstone, 2019) Karayurek, Fatih; Kadiroglu, Ela Tules; Nergiz, Yusuf; Akcay, Neslihan Coskun; Tunik, Selcuk; Kanay, Berna Ersoz; Uysal, Ersin
    Aim: The current study was based on the hypothesis that the use of PRF with bone graft materials might increase bone regeneration and focus on the histopathological and immunohistochemical aspects following application of PRF with autogenous graft, xenograft and B-TCP in a rabbit model. Material and methods: This study was performed on the twenty-eight male New Zealand divided into four group. Two defects with a diameter 10 mm were opened in calvarium. After PRF preparation, right defects were evaluated as empty defect or graft group, and left defects were evaluated as PRF test group. All animals were sacrificed at the end of 8 weeks and specimens were examined histopathologically and immunohistochemically. Results: The most superior histopathological results were obtained in the autograft group. The combination of beta-TCP-PRF could not provide superiority over the beta-TCP group. The immunohistochemical results showed that, in the PRF/BTCP group, the expression of osteopontin and osteonectin was relatively higher compared to the only-BTCP group. Conclusion: In terms of new bone formation, autograft combined with PRF yielded superior results but the combination of beta-TCP-PRF had no effect compared to the only-BTCP group. However, further experimental and clinical studies might be beneficial to clarify the exact mechanism and results of combining PRF with bone grafts on bone healing process. (C) 2019 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.
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    The effect of low-level laser therapy on the healing of hard palate mucosa and the oxidative stress status of rats
    (Wiley, 2014) Firat, Ela Tules; Dag, Ahmet; Gunay, Ahmet; Kaya, Beyza; Karadede, Mehmet Irfan; Kanay, Berna Ersoz; Ketani, Aydin
    [Abstract Not Available]
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    The Effects of Low-Level Laser Therapy on Palatal Mucoperiosteal Wound Healing and Oxidative Stress Status in Experimental Diabetic Rats
    (Mary Ann Liebert, Inc, 2013) Firat, Ela Tules; Dag, Ahmet; Gunay, Ahmet; Kaya, Beyza; Karadede, Mehmet Irfan; Kanay, Berna Ersoz; Ketani, Aydin
    Objective: The biostimulation effects of low-level laser therapy (LLLT) have recently been demonstrated. In this study, we aimed to investigate the effects of LLLT on palatal mucoperiostal wound healing and oxidative stress status in experimental diabetic rats. Materials and methods: Forty-two male Wistar rats that weighed 250-300 g were used in this study. Experimental diabetes was induced in all of the rats using streptozotocin. A standardized full thickness wound was made in the mucoperiosteum of the hard palates of the rats using a 3 mm biopsy punch. The rats were divided into groups: 1 (control group, non-irradiated), and 2 (experimental group, irradiated). Treatment using a GaAlAs laser at a wavelength of 940 nm and at dose of 10 J/cm(2) began after surgery, and was repeated on the 2nd, 4th, and 6th days post-surgery. Seven animals from each group were killed on the 7th, 14th, and 21st day after surgery. Biopsies were performed for the histological analysis and blood samples were collected by cardiac puncture for biochemical analysis. Results: The histopathological findings revealed reduced numbers of inflammatory cells, and increased mitotic activity of fibroblasts, collagen synthesis, and vascularization in rats in group 2. The total oxidative status was significantly decreased in the laser-treated group on the 21st day. Conclusions: LLLT elicits a positive healing effect on palatal mucoperiostal wounds, and modulates the oxidative status in experimental diabetic rats.
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    HISTOLOGICAL EXAMINATION OF THE EFFECTS OF LOW-LEVEL LASER THERAPY ON HEALING OF GINGIVA AFTER GINGIVECTOMY IN RATS
    (Taylor & Francis Ltd, 2013) Firat, Ela Tules; Dag, Ahmet; Gunay, Ahmet; Kanay, Berna Ersoz; Ketani, Sennur; Ketani, M. Aydin
    Lasers in dentistry find an increasing usage in recent years. The aim of this study was to assess the effects of low-level laser therapy (LLLT) on healing of gingiva after gingivectomy in rats. Forty-two male Wistar rats, 250 g to 300 g in weight, were used in this study. Gingivectomy was made to gingiva of mandibular incisors in all rats. The rats were divided into: group 1 (control group, non-irridated), and group 2 (experimental group, irridation-treated). After gingivectomy, a low-level laser therapy (LLLT) was applied to the side of the operation area. Treatment using a GaAlAs laser at a wavelength of 940 nm and a dose of 10 J/cm(2) began after surgery and was repeated on the 2nd, 4th and 6th day post-surgery. Seven animals from each group were sacrificed on the 7th, 14th and 21st day after surgery. Biopsies were performed for histological analysis. In the laser-treated grup, the histopathological findings revealed increased mitotic activity of fibroblasts and collogen synthesis on the 7th day, better formed epithelial layer, mild keratinization, collagen fibers and vascularization on day 14. On the 21st day after surgery, marked collagen fibers and vascularization was assesed according to the control group. The results of this study indicate that low-energy level laser therapy appeared to exert a positive effect in epithelization and wound healing after gingivectomy.