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    The Gigant primary cerebral hydatid cyst with no marked manifestation: a case report and review of literature
    (Verduci Publisher, 2015) Basarslan, S. K.; Gocmez, C.; Kamasak, K.; Ceviz, A.
    Hydatid cyst is a parasitic infestation that rarely affects the brain. A 14 year-old child with a large mass of intracranial hydatid cysts (122x110x98 mm), but no symptoms except for an intermittent headache for 2 months is presented. Triple cysts were removed after suitable craniotomy. The literature was reviewed and the case was compared with the published reports.
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    Neuroprotective effects of carvacrol and pomegranate against methotrexate-induced toxicity in rats
    (Verduci Publisher, 2013) Celik, F.; Gocmez, C.; Bozkurt, M.; Kaplan, I.; Kamasak, K.; Akil, E.; Dogan, E.
    BACKGROUND: Studies related to the use of various antioxidant and anti-inflammatory drugs to decrease the toxic side effects related to MTX have been carried out. However, since no medicine providing full protection against the side effects of MTX has been discovered, the discovery of new agents is required. AIM: The aim of this study was to determine whether methotrexate (MTX) causes oxidative stress and an inflammatory response in sciatic nerve, as well as whether carvacrol (CAR) and pomegranate (POM) have protective effects against the resulting oxidative stress and inflammatory response. MATERIALS AND METHODS: 32 adult male Wistar albino rats were used in the study. The animals were divided into 4 groups: Group C: the rats were not given any medication; Group MTX: On study day 2, the rats were given a single dose of 20 mg/kg MTX, administered intraperitoneally; Group MTX+CAR: On study day one, the rats were administered a single dose of 73 mg/kg CAR intraperitoneally. On study day two, a single dose of 20 mg/kg MTX was administered intraperitoneally; Group MTX+POM: For seven days starting from the study day one, rats were given 225 mg/kg POM extract once a day through orogastric gavage. On study day two, a single dose of 20 mg/kg MTX was administered intraperitoneally. All animals were sacrificed on the day eight. TOS, TAS, MDA, TNF-alpha and IL-1 beta levels were evaluated in the sciatic nerve tissue. RESULTS: In comparison to the control group, a decrease in TAS levels and an increase in TOS, MDA, IL-1 beta and TNF-alpha levels were detected in the MTX group. Compared to the MTX group, the MTX+CAR group had a significant increase in TAS level and significant decreases in TOS, MDA, IL-1 beta and TNF-alpha levels. In comparison to the MTX group, the MTX+POM group had a significant decrease in MDA, IL-1 beta and TNF-alpha levels. When the MTX+CAR and MTX+POM groups were compared, the TNF-alpha level measured was lower in the MTX+CAR group. CONCLUSIONS: In this work, we have shown that MTX causes a significant oxidative stress and inflammatory response in rats' sciatic nerve tissue and that CAR had an antioxidant effect in this system. Furthermore, we have proven, for the first time, that both CAR and POM decreased the pro-inflammatory response.