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    Combining platelet rich fibrin with different bone graft materials: An experimental study on the histopathological and immunohistochemical aspects of bone healing
    (Churchill Livingstone, 2019) Karayurek, Fatih; Kadiroglu, Ela Tules; Nergiz, Yusuf; Akcay, Neslihan Coskun; Tunik, Selcuk; Kanay, Berna Ersoz; Uysal, Ersin
    Aim: The current study was based on the hypothesis that the use of PRF with bone graft materials might increase bone regeneration and focus on the histopathological and immunohistochemical aspects following application of PRF with autogenous graft, xenograft and B-TCP in a rabbit model. Material and methods: This study was performed on the twenty-eight male New Zealand divided into four group. Two defects with a diameter 10 mm were opened in calvarium. After PRF preparation, right defects were evaluated as empty defect or graft group, and left defects were evaluated as PRF test group. All animals were sacrificed at the end of 8 weeks and specimens were examined histopathologically and immunohistochemically. Results: The most superior histopathological results were obtained in the autograft group. The combination of beta-TCP-PRF could not provide superiority over the beta-TCP group. The immunohistochemical results showed that, in the PRF/BTCP group, the expression of osteopontin and osteonectin was relatively higher compared to the only-BTCP group. Conclusion: In terms of new bone formation, autograft combined with PRF yielded superior results but the combination of beta-TCP-PRF had no effect compared to the only-BTCP group. However, further experimental and clinical studies might be beneficial to clarify the exact mechanism and results of combining PRF with bone grafts on bone healing process. (C) 2019 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.
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    Periodontitis is an important and occult source of inflammation in hemodialysis patients
    (Karger, 2006) Kadiroglu, Ali Kemal; Kadiroglu, Ela Tules; Sit, Dede; Dag, Ahmet; Yilmaz, M. Emin
    Aim:To evaluate the association between C-reactive protein (CRP) levels and the periodontal status of hemodialysis (HID) patients. Methods: 41 HID patients on rHuEPO therapy were enrolled in the study. Hematologic and biochemical parameters and CRP levels were recorded. The plaque index, gingival index, probing pocket depth and periodontal disease index were used to identify periodontal disease. The patients were divided into 2 groups: group 1 (n = 21), high CRP, and group 2 (n = 20), normal CRP. Results: After periodontal therapy, while the mean CRP level and erythrocyte sedimentation rate declined from 30.46 to 10.36 (p = 0.001) and from 93.4 to 35.8 mg/l (p = 0.001), respectively, the hemoglobin level increased from 9.4 to 10.6 g/dl (p = 0.009) and hematocrit level from 28.2 to 32.0% (p = 0.008) in group 1. Conclusion: Periodontitis is an important and occult source of chronic inflammation and increases the CRP levels in HD patients. Periodontitis can cause hyporesponsiveness to rHuEPO treatment and decrease the hemoglobin levels. Copyright (c) 2006 S. Karger AG, Basel
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    Restoring function and esthetics in 2 patients with amelogenesis imperfecta: Case report
    (Quintessence Publishing Co Inc, 2007) Ayna, Emrah; Celenk, Sema; Kadiroglu, Ela Tules
    This case report describes the prosthodontic treatment for a 28-year-old man and a 16-year-old boy diagnosed with amelogenesis imperfecta. The aim of treatment was to reduce dental sensitivity and to restore esthetics and masticatory function. Because of the socioeconomic status of the patients, direct resin composite laminate veneers were used to improve the esthetics of their maxillary and mandibular anterior teeth. Clinical examination 12 months after treatment revealed no evidence of disorders associated with the restored teeth or their supporting structures. Definitive treatment outcomes in terms of function and esthetics satisfied the expectations of both the patient and the interdisciplinary team.