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    Anatolian medicinal plants as potential antiviral agents: bridging traditional knowledge and modern science in the fight against COVID-19 and related viral infections
    (TUBITAK, 2024) Tilkat, Engin; Jahan, Israt; Hoşer, Ayşe; Kaplan, Alevcan; Özdemir, Oğuzhan; Onay, Ahmet
    The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was the cause of the coronavirus 2019 (COVID-19), commonly known as the coronavirus pandemic. Since December 2020, COVID-19 vaccines have been extensively administered in numerous countries. In addition to new antiviral medications, the treatment regimen encompasses symptom management. Despite sustained research efforts, the outbreak remains uncontrolled, with affected patients still lacking proper treatment. This review is a valuable asset for researchers and practitioners aiming to delve into the yet unexplored potential of Anatolian flora in the fight against COVID-19 and other viral infections. Numerous medicinal plants in Anatolia, such as thyme, sage, cannabis, oregano, licorice root, and Origanum sp., contain bioactive compounds with proven antiviral properties that have been used in the region for centuries. The rich legacy of traditional Anatolian medicine (TAM), has significantly influenced modern medicine; thus, the profusion of medicinal plants native to Anatolia holds promise for antiviral drug development, making this review essential for researchers and practitioners.
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    ç Batı Anadolu Üç Ahlat Türünün Antimikrobiyal Etkilerinin Belirlenmesi
    (2021) Ünal, Arzu; Kayhan, Rukiye; Korcan, Safiye E.; Jahan, Israt
    Bu çalışma, biri endemik olmak üzere Türkiye’de yetişen üç Ahlat türünün [Pyrus anatolica Browicz(Som Ahlat) Pyrus elaeagnifolia Pall. subsp. elaeagnifolia (Ahlat) Pyrus amygdaliformis Vill. var. Amygdaliformis (Çöğür Ahlat)] yaprak, dal ve meyve ekstrelerinin, antibakteriyel ve antifungal etkileri araştırılmıştır. Antimikrobiyal aktivitesi için agar kuyu difüzyon yöntemi kullanıldı çalışmada incelenecek her üç Ahlat türlerde hem antifungal hem de antibakteriyel etkiye sahip olduğu saptandı. Endemik bir tür olan Pyrus anatolica, diğer türlerle karşılaştırıldığında güçlü antimikrobiyal kapasiteye sahip olduğu belirlendi. Bu nedenle Pyrus anatolica ekstraktından gıda katkı maddesi, tıp ve sağlık alanlarında yararlanılabileceği düşünülmektedir.
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    The Effects of Silver Nanoparticles (AgNPs) on Thermophilic Bacteria: Antibacterial, Morphological, Physiological and Biochemical Investigations
    (Mdpi, 2024) Jahan, Israt; Bekler, Fatma Matpan; Tunc, Ahmed; Guven, Kemal
    Since thermophilic microorganisms are valuable sources of thermostable enzymes, it is essential to recognize the potential toxicity of silver nanoparticles used in diverse industrial sectors. Thermophilic bacteria Geobacillus vulcani 2Cx, Bacillus licheniformis 3CA, Paenibacillus macerans 3CA1, Anoxybacillus ayderensis FMB1, and Bacillus paralicheniformis FMB2-1 were selected, and their MIC and MBC values were assessed by treatment with AgNPs in a range of 62.5-1500 mu g mL(-1). The growth inhibition curves showed that the G. vulcani 2Cx, and B. paralicheniformis FMB2-1 strains were more sensitive to AgNPs, demonstrating a reduction in population by 71.1% and 31.7% at 62.5 mu g mL(-1) and by 82.9% and 72.8% at 250 mu g mL(-1), respectively. TEM and FT-IR analysis revealed that AgNPs caused structural damage, cytoplasmic leakage, and disruption of cellular integrity. Furthermore, cell viability showed a significant decrease alongside an increase in superoxide radical (SOR; O-2(-)) production. beta-galactosidase biosynthesis decreased to 28.8% level at 500 mu g mL(-1) AgNPs for G. vulcani 2Cx, 32.2% at 250 mu g mL(-1) for A. ayderensis FMB1, and 38.8% only at 62.5 mu g mL(-1), but it was completely inhibited at 500 mu g mL(-1) for B. licheniformis 3CA. Moreover, B. paralicheniformis FMB2-1 showed a significant decrease to 11.2% at 125 mu g mL(-1). This study is the first to reveal the toxic effects of AgNPs on thermophilic bacteria.
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    Potentials of plant-based substance to inhabit and probable cure for the covid-19
    (Scientific and Technical Research Council of Turkey, 2020) Jahan, Israt; Onay, Ahmet
    COVID-19 has been the most devastating pandemic in human history. Despite the highest scientific efforts and investments, a reliable and certified medication has yet to be developed regarding to immune or cure this virus. However, while synthetic medications are gaining the focus of attentions, it appears from a significant number of recent studies that plant-based substances could also be potential candidates for developing effective and secure remedies against this novel disease. Citing such recent works, this review primarily demonstrates the antiviral potentials of medicinal plants for inhibiting human coronaviruses. It also shows the importance of antiviral plants substances, particularly in the development of a broad spectrum medication for coronaviruses including SARS-CoV-2 responsible for COVID-19
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    Proliferative Effect of Gum Tragacanth on Different Cancer Cells
    (2024) İrtegün Kandemir, Sevgi; Jahan, Israt; Teke, Fatma
    Gum tragacanth (GT) is a natural plant exudate discharged from the twigs and stems of Asiatic species of the Astragalus genus. GT is a heterogeneous polysaccharide which has been utilized in various biomedical fields and traditionally in ethnomedicine because of its distinctive physicochemical and biological properties, such as great biocompatibility, thermal stability biodegradability, hydrophilicity and antioxidant activity. The aim of this study was to examine whether GT has cytotoxic effects on various cancer cell lines. For this aim, four cancer cell lines i.e., human colorectal adenocarcinoma (CACO-2), glioblastoma multiforme tumor (T98G), ovarian sarcoma (SKOV-3), and breast cancer (MCF-7) cells were used. GT was prepared at the concentration of 200 µg/mL, 100 µg/mL, 50 µg/mL, 25 µg/mL and 12.5 µg/mL, using both 5% DMSO and dH2O as solvent. MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) colorimetric assay was used for in vitro cytotoxicity study. GT had no cytotoxic effect on these cancer cells since cell viability percentages were found to be above 80% for all the treatments. However, remarkable dose-dependent cell proliferation efficiency of GT at certain concentrations was observed on all cancer cells except MCF-7. In conclusion, this study suggests that cancer patients should be careful about the use of GT or products containing GT due to the increasing effect of GT on the proliferation of cancer cells.
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    Öğe
    Proliferative Effect of Gum Tragacanth on Different Cancer Cells
    (Iğdır Üniversitesi, 2024) Kandemir, Sevgi İrtegün; Jahan, Israt; Teke, Fatma
    Gum tragacanth (GT) is a natural plant exudate discharged from the twigs and stems of Asiatic species of the Astragalus genus. GT is a heterogeneous polysaccharide which has been utilized in various biomedical fields and traditionally in ethnomedicine because of its distinctive physicochemical and biological properties, such as great biocompatibility, thermal stability biodegradability, hydrophilicity and antioxidant activity. The aim of this study was to examine whether GT has cytotoxic effects on various cancer cell lines. For this aim, four cancer cell lines i.e., human colorectal adenocarcinoma (CACO-2), glioblastoma multiforme tumor (T98G), ovarian sarcoma (SKOV-3), and breast cancer (MCF-7) cells were used. GT was prepared at the concentration of 200 µg/mL, 100 µg/mL, 50 µg/mL, 25 µg/mL and 12.5 µg/mL, using both 5% DMSO and dH2O as solvent. MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) colorimetric assay was used for in vitro cytotoxicity study. GT had no cytotoxic effect on these cancer cells since cell viability percentages were found to be above 80% for all the treatments. However, remarkable dose-dependent cell proliferation efficiency of GT at certain concentrations was observed on all cancer cells except MCF-7. In conclusion, this study suggests that cancer patients should be careful about the use of GT or products containing GT due to the increasing effect of GT on the proliferation of cancer cells.