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Meropenem monotherapy for empiric treatment of febrile neutropenic cancer patients
(Medimond S R L, 2000) Ayyildiz, O; Iskakdogan, A; Bolaman, Z; Müftüoglu, E
Empirical antibacterial therapy should be administered to all neutropenic cancer patients with fever or clinical evidence of infection even in the absence of fever. A total of fifty cancer patients with 72 neutropenic episodes were enrolled in the study. Twenty-one (29%) episodes had a microbiologically defined infection, 20 (28%) a clinically defined infection and the remaining 31 (43%) had unexplained fever. 72 episodes initially treated with meropenem 1 g i.v. every 8 h. Gram negative pathogens were 11 (52%) predominated over gram positive isolates were 7 (33%). The success rate without adjustment was 29% in gram positive group and 91% in gram negative group. There were no reports of drug-related nausea/ vomiting or seizures. One patient with AML died of gram positive sepsis resistant to treatment. In conclusion,meropenem monotherapy seemed effective and side effects were tolerable for the treatment of febrile neutropenic cancer patients.