Yazar "Isikdogan, A" seçeneğine göre listele

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    5-fluorouracil-induced vasospastic angina
    (K Faisal Spec Hosp Res Centre, 2005) Ayyildiz, O; Karabulut, O; Isikdogan, A; Cakir, O; Dursun, M
    [Abstract Not Available]
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    Aase-Smith syndrome type II
    (Saudi Med J, 2004) Soker, M; Ayyildiz, O; Isikdogan, A
    Aase-Smith syndrome type II is rare in childhood and there are few reported cases. Here, we report an 8-month-old boy with congenital red cell aplasia and triphalangeal thumbs. In addition to thumb anomalies, he presented with growth failure, hypertelorism and novel osseous radiologic abnormalities, large fontanelles and micrognathia as extraordinary. Some clinical symptoms had complete clinical remission with deflazacort treatment.
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    Factor V Leiden mutation in venous thrombosis in southeast Turkey
    (Sage Publications Inc, 2006) Kalkanli, S; Ayyildiz, O; Tiftik, N; Batun, S; Isikdogan, A; Ince, H; Tekes, S
    Venous thrombosis (VT) is a common disease, with an annual incidence in the general population of approximately I per 1,000. Factor V Leiden mutation (G1691A) (FVL) is the most common risk factor in venous thrombosis. The prevalence of FVL for thrombosis varies greatly in different regions of the world. FVL mutation has been identified both by conventional method and fluorescence resonance energy transfer (FRET) with the LightCycler. Sixty-one patients with VT, different in age and sex, were consecutively entered into this study to assess the prevalence of FVL in VT in southeast Turkey. FVL mutation was found in 24.6% (15/61). Fourteen individuals were heterozygous and I homozygous, a rate of 22.9% and 1.6%, respectively. In conclusion, the authors suggest that FVL mutation is common in patients with venous thrombosis in southeast Turkey.
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    Fever due to malaria in a neutropenic patient. A rare complication of blood transfusion
    (Saudi Med J, 2004) Isikdogan, A; Ayyildiz, O; Soker, M; Yakut, M; Muftuoglu, E
    [Abstract Not Available]
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    Fludarabine as a second-line treatment of advanced stage chronic lymphocytic leukemia
    (Saudi Med J, 2004) Ayyildiz, O; Isikdogan, A; Bolaman, Z; Muftuoglu, E
    [Abstract Not Available]
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    Hepatitis C virus in patients with non-Hodgkin's lymphoma in southeastern Anatolia region of Turkey: A prospective case-control study of 119 patients
    (Taylor & Francis Ltd, 2003) Isikdogan, A; Ayyildiz, O; Dursun, M; Tiftik, N; Batun, S; Muftuoglu, E
    Hepatitis C virus (HCV) has been associated with several extrahepatic disorders including mixed cryoglobulinemia (MC), autoimmune thyroiditis, Sjogren's syndrome. Such associations have led to the suggestion that HCV may participate in the development of various immunmediated disorders. Recently, it has been hypothesised that HCV might act as a trigger for the development of monoclonal B-cell disorders such as non-Hodgkin's lymphoma (NHL). Discordant data have been reported in different geographic regions of the world. The aim of this prospective case-control study was to detect the prevalence of HCV in patients with NHL in southeastern Anatolia region of Turkey. In this study, HCV antibody prevalence and cryoglobulinemia were investigated in 119 patients with histologically diagnosed NHL. The control group consisted of 117 patients who visited the outpatient clinic of internal medicine. None of the patients had HCV antibody positive (0%) with the enzyme immunoassay and reverse transcriptase polymerase chain reaction (RT-PCR). One of the control patients had positive HCV antibody (0.9%). Our data does not support the association between HCV infection and NHL in southeastern Anatolia region of Turkey.
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    Hodgkin's disease variant of Richter's transformation -: A case report
    (Humana Press Inc, 2002) Isikdogan, A; Ayyildiz, O; Büyükbayram, H; Müftüoglu, E
    Hodgkin's disease rarely develops in patients with B-chronic lymphocytic leukemia. Patients developing Hodgkin's disease after the diagnosis of chronic lymphocytic leukemia have been called the Hodgkin's disc, ease variant of Richter's transformation. We present a 62-yr-old man with a 17-mo history of chronic lymphocytic leukemia, who clinically and hematologically on remission was admitted to our clinic because of rapidly developing right cervical lymphadenopathy. He was diagnosed with lymph node biopsy as a mixed-cellularity Hodgkin's disease.
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    The importance of CD7 and CD56 antigens in acute leukaemias
    (Wiley, 2004) Tiftik, N; Bolaman, Z; Batun, S; Ayyildiz, O; Isikdogan, A; Kadikoylu, G; Muftuoglu, E
    The prognostic significance of immunophenotypical properties of leukaemic cells is well known. However, the biological and clinical significance of CD7 and CD56 antigen expression in acute leukaemias are not clearly established. In patients with acute leukaemias, we identified CD7 and CD56 expression and analysed their associations with markers expressed early in haemopoietic ontogeny and clinical parameters. Among 22 patients with acute leukaemia [12 acute myeloblastic leukaemia (AML), 10 acute lymphoblastic leukaemia (ALL)], we found CD7 positivity in 15 of 22 patients (68%) and CD56 positivity in four patients (18%). CD7 positivity was observed in seven patients (58%) with AML and in eight patients (80%) with ALL. CD56 positivity was observed in three patients (25%) with AML and one patient (10%) with ALL. Lymphadenopathy was present in five patients and associated with hepatosplenomegaly in three patients with ALL. Splenomegaly and hepatomegaly were present in three patients with AML. Central nervous system involvement was seen in one patient with ALL. Complete remission was achieved in nine patients (41%) (five ALL and four AML). Our data showed that CD7 and CD56 positivity at diagnosis associated with low remission rate and biological aggressiveness in a significant proportion of patients. We suggest the evaluation of CD7 and CD56 in all patients with acute leukaemias at the time of diagnosis in view of poor clinical outcome.
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    Intracranial meningeal extramedullary hematopoiesis inducing serious headache in a patient with idiopathic myelofibrosis
    (Lippincott Williams & Wilkins, 2004) Ayyildiz, O; Isikdogan, A; Celik, M; Muftuoglu, E
    [Abstract Not Available]
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    Late relapse of non-Hodgkin's lymphoma after a 28-year disease-free interval: an unusual case
    (Springer-Verlag, 2003) Isikdogan, A; Ayyildiz, O; Buyukcelik, A; Soker, M; Buyukbayram, H
    [Abstract Not Available]
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    Non-Hodgkin's lymphoma in southeast Turkey: clinicopathologic features of 490 cases
    (Springer, 2004) Isikdogan, A; Ayyildiz, O; Buyukcelik, A; Arslan, A; Tiftik, N; Buyukbayram, H; Muftuoglu, E
    We have carried out a retrospective analysis of 490 non-Hodakin's lymphomas (NHLS), followed at our clinic, with the purpose of evaluating the clinicopathologic features of these patients. The patients were assessed with regard to their characteristics including age gender. histologic distribution, stage, extranodal involvement. presenting symptoms, and biopsied site. Of the patients 314 (64%) were male and 176 (36%) were female. The overall median age was 43 years (range: 1490). The patients were classified according to the Working Formulation (WF) system: 71 (14.4%) were low grade, 342 (69.8%) were intermediate grade, 43 (8.7%) were high grade, and 34 (6.7%) had other lymphomas. Intermediate-grade non-Hodgkin's lymphomas formed the largest group, of whom 320 patients' paraffin blocks were available for Revised European and American lymphoma (REAL) classification: 78% were B-cell lymphomas, whereas 16% were T/NK lymphomas. Six percent of cases were unclassified lymphomas. Diffuse large B-cell lymphoma (DLBCL) was the most commonly observed histopathologic type in 132 (41%) patients. Extranodal involvement was found in 218 (44.5%) patients. The most commonly affected extranodal sites were small bowel, stomach, and tonsil in 72 (33%), 63 (29%), and 19 (8.7%) patients, respectively. According to the Ann Arbor staging system, the vast majority of patients (89.4%) were advanced stage. In conclusion, the characteristics of NHLs in our region show some differences from the other sites of Turkey and the world.
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    Primary squamous cell carcinoma of the stomach
    (Lippincott Williams & Wilkins, 2003) Dursun, M; Yaldiz, M; Isikdogan, A; Yilmaz, G; Canoruç, F; Örmeci, N; Yilmaz, S
    Primary squamous cell carcinoma of the stomach is extremely rare. To date, only 80 cases have been reported. A 65-year-old man with complaints of epigastric pain and cachexia for the past year is presented. He had a tumour with infiltration of the corpus and antrum of the stomach. The tumour was unresectable, and the patient died within 3 months.
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    Prothrombin G20210A gene mutation with LightCycler polymerase chain reaction in venous thrombosis and healthy population in the southeast of Turkey
    (Springer, 2004) Ayyildiz, O; Kalkanli, S; Batun, S; Aybak, M; Isikdogan, A; Tiftik, N; Bolaman, Z
    Venous thrombosis (VT) is a common disease, with an annual incidence in the general population of approximately 1 per 1000. The prevalence of genetic risk factors for thrombosis varies greatly in different parts of the world. Prothrombin G20210A (PT G20210A) gene mutation has been recently identified as a common risk factor in venous thrombosis. Sixty-one patients with VT, differing in age and sex, and 340 healthy subjects were consecutively enrolled into our study to determine the prevalence of PT G20210A in VT and in the healthy population of the southeast of Turkey. The mutation was identified with fluorescence resonance energy transfer (FRET) with the LightCycler polymerase chain reaction. The PT G20210A mutation was found to be 6.5% (4/61) in the VT group and 1.2% (4/340) in the healthy group (P = 0.021). Three patients with VT had a heterozygous PT G20210A mutation, and the other patient with VT had both Factor V Leiden and PT G20210A mutations. We showed that this method may be used safely for detection of the PT G20210A gene mutation, and the prevalence of PT G20210A mutation is significantly higher in patients with VT than in the healthy population in the southeast of Turkey.
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    Type III mixed cryoglobulinemia associated with digital necrotic ulcer successfully treated with intermittent intravenous pulse cyclophosphamide - A case report
    (Sage Publications Inc, 2005) Cakir, O; Ayyildiz, O; Isikdogan, A
    Cryoglobulinemic vasculitis is an immune complex-mediated vasculitis predominantly affecting small vessels. The authors report an 18-year-old woman with painful digital necrotic ulcer due to type III cryoglobulinemic vasculitis on the basis of systemic lupus erythematosus. Serum protein electrophoresis and immunoelectrophoresis demonstrated a polyclonal peak of the immunoglobulin G lambda (IgG lambda) and IgM lambda type. The patient was successfully treated with intermittent intravenous pulse cyclophosphamide.