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Öğe Changes in serum paraoxonase activity, calcium and lipid profiles in pre-eclampsia, a preliminary study(2011) Babacan F.; Isik B.; Bingol B.Objective: To investigate serum paraoxonase (PON1) activity, serum calcium, and lipid profiles in pre-eclampsia. Material and methods: Serum PON1 activity, calcium, and lipid profiles were measured in a cohort of 45 women with normal pregnancies (11 patients) and pre-eclampsia (34 patients). Results: Triglyceride, total cholesterol, and LDL cholesterol concentrations were significantly increased in women with pre-eclampsia, compared with women with normal pregnancies. Serum HDL cholesterol, PON1, and calcium levels in pre-eclamptic patients were significantly lower than those in healthy pregnant women. Conclusion: The significant decrease of PON1 activity in pre-eclampsia is related to lipid profiles and calcium.Öğe The effect of exogen glutathione administration on the gastric mucosal barrier in rats under stress(1998) Kanay Z.; Sert C.; Isik B.; Kurt D.; Guzel C.; Mete N.We investigated the effect of glutathione (GSH) on the gastric mucosal barrier of rats under stress. Twenty two swiss Albino rats weighing between 150-200 g were used and stress was induced by cold and immobilisation. GSH was administered in 300 mg/kg doses to the study group and oral saline was given to a control group. Mucus and phospholipid levels of the gastric mucosal barrier were then measured using come and Baur's methods. These important components of the gastric mucosal barrier were found to be decreased (p<0.05), but levels were higher in rats given GSH than in the control group (p<0.01, p<0.05 respectively). To conclude, GSH was found to be effective in preventing gastric mucosal barrier damage caused by stress.Öğe Effects of urokinase on postoperative intraabdominal adhesion formation and healing of bowel anastomosis(1997) Otcu S.; Onen A.; Dokucu A.I.; Ozer M.; Isik B.; Deveci E.; Ozdemir E.Urokinase with its' proteolytic enzyme activity, has been frequently used in experimental studies on postoperative intraperitoneal adhesion formation. As wound healing process may be effected with the same mechanism, we aimed to investigate if intraperitoneal administration of urokinase increases the rate of anastomotic complications. For every ten rats of the control and urokinase group, laparotomy and colonic anastomosis are performed. In the urokinase group abdominal cavities are irrigated with 2000 IU of urokinase. All the rats are sacrificed at postoperative seventh day and adhesion scoring, anastomosis bursting pressure and histopathological findings are investigated. There is no anastomotic leakage in both groups. Adhesion score in control group (2.6±0.52) was significantly higher than urokinase group (1.1±0.74). Differences in anastomotic bursting pressure between the groups were not statistically significant. Although serosal and mucosal continuity were not achieved properly due to excessive fibroblastic activity in control animals, it could be obtained in the urokinase group sufficiently. Our findings support the efficacy of urokinase in preventing the postoperative intraabdominal adhesion formation, while the healing process at the anastomotic site is not alter with its' intraperitoneal administration.Öğe The evaluation of paraoxonase 1 activity in patients with gestational diabetes(Acta Medica Mediterranea, 2013) Atay A.E.; Sakar M.N.; Culcu N.S.N.; Simsek H.; Akbas H.; Acar M.; Isik B.Material and methods: Sixty five patients with GDM and 66 healthy pregnants were enrolled. Paraoxonase activity, insulin levels, HOMA-IR, demographic features and anthropometric measurements were evaluated. Results: The mean paraoxonase activity was significantly diminished in patients with GDM (p:0,004). Insulin level and HOMA-IR were significantly higher in GDM patients (p:0,004 and p:0,001; respectively). The mean interval between present and previous pregnancy was significantly shorter in patients group (p:0,004). There was a significant correlation between PON1 activity and serum LDL, HDL levels and weight gained during pregnancy (p:0,001,p<0,001 and p:0,002; respectively) but not with weight and parity. However HOMA-IR was significantly correlated with weight and parity (p:0,001 and p:0,002; respectively). Discussion: Diminished PON1 activity and enhanced oxidative stress accompany to insulin resistance in the pathogenesis of GDM. Oxidative stress is associated with weight gained during first 2 trimesters of pregnancy rather than obesity.Öğe Investigation of periodontal parameters, total antioxidant status and ferritin levels in patients with thalassemia major(University of Dicle, 2015) Gunay A.; Dogru A.G.; Isik B.; Soker M.; Gunay A.Our aim was to investigate periodontal status and total antioxidant status (TAS), ferritin levels of serum and gingival crevicular fluid (GCF) in patients with thalassemia major. This study comprised 73 individuals aged between 11 and 16 years, divided into 3 groups; Group TMS: periodontally healthy 23 patients with thalassemia major, Group TMG: 25 patients with gingivitis and thalassemia major, and Group C: gingival and systemically healthy 25 individuals. Firstly, Plaque Index (PI), Gingival Index (GI) and Probing Depth (PD) data of all individuals in the study were recorded. For serum samples, 5 cc blood was taken from the antecubital region of the forearm of every individual. At the same time 4 samples of GCF were taken from the maxillar incisive of every individual, collected by standard Periopaper strips. In the comparison of total mouth of the TMG group with the C and TMS groups, GI, PI, PD and GCF volume values were higher in the TMG group as expected (p<0.001). In the evaluation of the TMS and TMG groups in comparison with the C group, statistically significant differences were determined in the ferritin and TAS values of both GCF and serum (P<0.05). No correlation was found in the clinical and biochemical parameters investigated in serum and GCF of the TMG and TMS groups (p>0.05). In this study of relatively few patients, the conclusion was reached that thalassemia major was not a direct risk factor in the formation of gingivitis. Further studies are needed to investigate the relationship between more severe periodontal disease and thalassemia major in different age groups.
