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Öğe Effect of winter air pollution on lipid peroxidation product levels of patients with chronic obstructive pulmonary disease(Mrs Pushpa Agarwal, 2006) Isik, B; Hamamci, C; Isik, RAir pollution and its effects on human health have been considered to the a serious problem in urban areas. The health hazards of outdoor air pollution are manifest across a wide spectrum of effects. Patients with. respiratory disease and chronic obstructive pulmonary disease (COPD), given their abnormal responses to noxious gases and particles. The causes of oxidative stress in COPD are cigarette smoking, air pollution and increase of free radicals in respiratory epithelial cells by inflammation and infections. In the present study, we aim to investigate the effect on oxidative stress due to air pollution in patients with COPD in Diyarbakir (SE Anatolia) Turkey. Clinically stable COPD outpatients (n = 52) and healthy controls (n = 42) were studied. The lipid peroxidation product malonyldialdehyde (MDA) in serum samples was measured spectrophometrically by the Buege method. The serum MDA levels of patients with COPD (3.06 +/- 0.7 nmol/ml) were significantly higher than those of control groups (0.62 +/- 0.19 nmol/mL) (p < 0,001)Öğe High-resolution computed tomography in cases with environmental exposure to asbestos in turkey(Karger, 2000) Topçu, F; Bayram, H; Simsek, M; Kaya, K; Özcan, C; Isik, R; Senyigit, ABackground and Objectives: Although all parts of the lung can be affected as a consequence of asbestos exposure, most CT protocols tend to scan only the middle and lower parts of the thorax. The aim of this study was to investigate parenchymal and pleural lesions of persons exposed to environmental asbestos, using a high-resolution computed tomography (HRCT) protocol scanning the whole thorax. Methods: We analyzed the chest radiographs and HRCT scans of 26 patients who presented bilaterally with multiple pleural plaques related to environmental asbestos exposure. Results: Twenty-four cases (92%) had an abnormal HRCT suggestive of asbestosis. Apart from common HRCT changes related to asbestosis, we detected apical pleural thickening (APT) in 9 cases as well as a coarse honeycomb pattern adjacent to APT in 7 of these cases. Cavitary lesions due to pulmonary tuberculosis were observed on HRCT scans from 4 patients in total. Neither apical pulmonary fibrosis nor cavitary lesions were visible on chest radiographs. Conclusions: We suggest that the HRCT protocol for examining asbestos-exposed individuals with pleural plaques on chest X-rays should include the whole thorax, since the asbestos-related pathologies may involve all parts of the lung. Copyright (C) 2000 S. Karger AG. Basel.Öğe Incidence of malignant pleural mesothelioma due to environmental asbestos fiber exposure in the southeast of Turkey(Karger, 2000) Senyigit, A; Babayigit, C; Gökirmak, M; Topçu, F; Asan, E; Coskunsel, M; Isik, RBackground: Inhabitants of the southeast of Turkey (ST) have been exposed since childhood to inhalation of asbestos, from a material containing tremolite, used for whitewashing. This has resulted in an increased incidence of malignant pleural mesothelioma (MPM). Objectives: To review the epidemiological features of MPM cases in ST; to calculate and compare the incidence with the previously reported ones. Subjects and Methods: The study included 176 MPM cases from different places in ST. The incidence of MPM was calculated for those places according to the distribution of the cases. Results: In the previously identified regions of asbestos (region 1) where the population had been informed of the danger with the soil some decades ago, the MPM incidence was decreased, as compared to the previous reports. The annual incidence of MPM in these places was found to be 42.9 per million in this study while it had been reported to be 105.5 per million in the previous studies. In contrast, the incidence that was reported previously to be 2.75 per million in the regions where asbestos exposure had not been identified before (region 2] was found to be 8.6 per million in this study. In region 2 the incidence of MPM increased even in the second ha If of the last decade (5.9 versus 11.9 per million). Conclusions: Use of asbestos-containing soil continues in different places in ST. Even if the use of this soil is abandoned today, MPM will be an important health problem in this region till the third or fourth decades of this century. Informing the villagers of the danger and preventing the use of this soil may result in a considerable decrease in the incidence of MPM. Copyright (C) 2000 s. Karger AG, Basel.Öğe Peritoneal mesothelioma associated with exposure to asbestos in Southeastern Turkey(Lippincott Williams & Wilkins, 2002) Degertekin, H; Yalçin, K; Isik, R[Abstract Not Available]
