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    Effects of Potentilla Fulgens as a Prophylactic Agent in Testicular Ischemia-Reperfusion Injury
    (Sci Printers & Publ Inc, 2016) Karabulut, Ozlen; Kalkanli, Sevgi Tas; Deveci, Engin; Isen, Kenan; Uysal, Ersin; Soker, Ipek Sevda
    OBJECTIVE: To study the protective effects of Potentilla fulgens extract on damage of testicular tissue created by ischemia and reperfusion treatment via histopathological, immunohistochemical, and TUNEL experiments. STUDY DESIGN: In this study 24 Sprague-Dawley male rats were divided into 4 subgroups: control group, torsion group, torsion-detorsion group, and Potentilla fulgens +torsion-detorsion group. The extract of Potentilla fulgens was intraperitoneally injected into the rats, 400 mg/kg for 5 days. The right testicle was exposed to torsion and detorsion for 2 hours with a 720 turn. The right testicle was dissected from the scrotum after the rats were anesthetized with ketamine hydroxide. Following fixation of 10% formaldehyde solution, routine tissue processing protocol was applied. Immunohistochemically slides were stained with TNF-alpha antibody. Apoptotic changes were examined using the TUNEL protocol. RESULTS: In this study seminiferous tubule diameter and depth of spermatic cells were compared among the experimental and control groups. Histopathologic examination shows that degeneration and disorganization of the spermatic cells and changes in tubule diameter were found to be statistically significant. In addition, histopathological examination of the apoptotic indices was scored using the TUNEL method. Immunohistochemically, TNF-a expression was positively observed in the ischemia and the ischemia-reperfusion groups. CONCLUSION: As a result of torsion and detorsion exposure, which led to damage in spermatic cells of seminiferous tubules, Potentilla fulgens was shown to decrease apoptotic development and was thought to be the cause of activation in spermatic cells.
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    Effects of Pulsed and Sinusoidal Electromagnetic Fields on MMP-2, MMP-9, Collagen Type IV and E-cadherin Expression Levels in the Rat Kidney An Immunohistochemical Study
    (Sci Printers & Publ Inc, 2013) Tunik, Selcuk; Ayaz, Ercan; Akpolat, Veysi; Nergiz, Yusuf; Isen, Kenan; Celik, M. Salih; Seker, Ugur
    OBJECTIVE: To investigate the role of extremely low frequency pulsed and sinusoidal electromagnetic fields on kidney tissues. STUDY DESIGN: Twenty-seven male Wistar albino rats were used. The rats were divided into 3 groups (n = 9): control group, sinusoidal electromagnetic field (SEMF) group, and pulsed electromagnetic field (PEMF) group. The SEMF and PEMF groups (pulse time 25 mu sn, pulse frequency 50 Hz) were subjected to 1.5 mT, 50 Hz, exposure 6 hours a day, 5 days a week for 28 days in methacrylate boxes. Formalin-fixed, paraffin-embedded kidney tissue sections were stained with hematoxylin-eosin, Gomori and periodic acid-Schiff. In addition, matrix metalloproteinase-2 (MMP-2) and 9 (MMP-9), E-cadherin and collagen type IV expression levels were examined immunohistochemically. RESULTS: Thickening of glomerular basement membranes was evident in electromagnetic fields, especially in the SEMF group. In addition, expression levels of E-cadherin were decreased with electromagnetic field (EMF) exposure. The expression level of MMP-9 increased, and MMP-2 and collagen type IV expression levels were not altered with EMF exposure. CONCLUSION: Both EMFs changed the molecular component of the kidney adversely.
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    Giant vesical diverticulum: A rare cause of defecation disturbance
    (Baishideng Publishing Group Inc, 2009) Akbulut, Sami; Cakabay, Bahri; Sezgin, Arsenal; Isen, Kenan; Senol, Ayhan
    Vesical diverticula frequently result from bladder outlet obstructions. However, giant vesical diverticula which cause acute abdomen or intestinal obstruction are very rare. Our review of the English medical literature found 3 cases of bladder diverticula which caused gastrointestinal symptoms. Here, we present a 57-year-old man with a giant diverticulum of the urinary bladder who complained of abdominal pain, nausea and vomiting, constipation, no passage of gas or feces, and abdominal distension for 3 d. A 20 cm x 15 cm diverticulum was observed upon laparotomy. The colonic obstruction was secondary to external compression of the rectum against the sacrum by a distended vesical diverticulum. We performed a diverticulectomy and primary closure. Twelve months postoperatively, the patient had no difficulty with voiding or defecation. (c) 2009 The WJG Press and Baishideng. All rights reserved.
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    Incidence, clinical findings and management of intraoperative floppy iris syndrome associated with tamsulosin
    (Wiley-Blackwell Publishing, Inc, 2009) Keklikci, Ugur; Isen, Kenan; Unlu, Kaan; Celik, Yusuf; Karahan, Mine
    To determine the risk ratios and incidence of intraoperative floppy iris syndrome (IFIS) during cataract surgery in patients using tamsulosin, and to assess management strategies for IFIS. We performed a non-randomized, observational, prospective study, in which 594 eyes of 579 patients undergoing cataract surgery were enrolled. Surgeons were masked to the patients' drug history. Usage or non-usage of tamsulosin, duration of tamsulosin use, presence or absence of IFIS, management of IFIS and intraoperative complications were recorded in the patients' theatre notes. Twelve of 15 (80%) IFIS patients were taking systemic tamsulosin. Twelve of 23 (52%) patients using tamsulosin showed features of IFIS. The odds ratios (ORs) and relative risk (RR) ratios show strong positive correlations between tamsulosin use and IFIS. The ORs and RR ratios and the 95% confidence intervals (CIs) are as follows: OR 206.5 (95% CI 50.9-836.5); RR 99.3 (95% CI 30.0-327.8). There were no statistically significant differences between patients with or without IFIS, who were using tamsulosin, in terms of age or duration of tamsulosin use (p > 0.05). Seven eyes (46.6%) with IFIS were successfully managed with epinephrine. Eight eyes (53.4%) with IFIS needed iris hooks. Patients using tamsulosin appear to be at high risk of IFIS during cataract surgery. The occurrence of IFIS may not be affected by duration of tamsulosin use or age. Epinephrine may be effective in approximately 50% of eyes with IFIS. The iris hook procedure represents an effective management strategy in IFIS.
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    INTRAOPERATIVE FLOPPY IRIS SYNDROME (IFIS) DUE TO TAMSULOSIN USE : UROLOGICAL APPROACH
    (Marmara Univ, Fac Medicine, 2008) Isen, Kenan; Keklikci, Ugur
    Intraoperative floppy iris syndrome(IFIS) is new syndrome which has been recently described in patients undergoing cataract surgery and taking tamsulosin for managing benign prostate hyperplasia(BPH). This syndrome is characterized by flaccid iris stroma, a propensity of the iris to prolapse toward the corneal incision, and progressive miosis, all conditions that potentially increase the risk of intraoperative complications. Current or past use of alpha-1 blockers in patients undergoing cataract surgery should be known by oftalmologist to reduce the risk of complications during surgery. Urologists should not change the prsecribing habits of alpha-1 blockers. However, they considering prescribing a selective alpha-blocker should ask the patient if they have known cataracts and if surgery is planned.
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    Lymphangioma Circumscriptum of the Glans Penis Treated with Advanced Fluorescence Technology Pulsed Light Therapy: Case Report
    (Ortadogu Ad Pres & Publ Co, 2010) Demir, Ektan; Isen, Kenan; Buyukbayram, Huseyin
    Lymphangioma circumscriptum (LC) of the glans penis is an extremely rare situation. A 34-year-old man was referred to us with multiple lesions on the glans penis. On examinaton, multiple, dark red-colored papular lesions were seen on the glans penis. Punch biopsy was obtained, and the diagnosis was made with histopathological examination. Patient was treated with advanced fluorescence technology pulsed light (AFPL) (Harmony 540 nm, msq co. Alma) therapy. Although complete improvement was achieved after three sessions of AFPL therapy, recurrence was observed after nine months. No complications was observed during the procedures. We suggest that AFPL therapy might be considered as an alternative treatment option for LC of the glans penis, however, patients should be informed about the possibility recurrence.
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    Retroperitoneal Fibrosis and Hydronephrosis due to Actinomycosis
    (Mary Ann Liebert, Inc, 2009) Akbulut, Sami; Cakabay, Bahri; Sezgin, Arsenal; Ozmen, Cihan Akgul; Isen, Kenan; Bakir, Cetin
    Purpose: In this article, we present a case of actinomycosis causing fibrosis and bilateral obstructive uropathy. Methods: A 43-year-old woman was admitted to the hospital with left flank pain. Abdominal computed tomography showed bilateral hydroureteronephrosis and a malignant mass. The fine-needle aspiration biopsy was reported as retroperitoneal fibrosis. Stents were placed in both ureters. Two (2) months later, laparotomy revealed a mass located just below the origin of the inferior mesenteric artery. Bilateral ureterolysis and sigmoid colon resection was performed. Results: The pathology report was fibrosis and actinomycosis. She was given parenteral crystallized penicillin 4 x 5 million units/day for 21 days, followed by oral cotrimoxazole (960 mg) for 6 months. Conclusions: Because actinomycosis was not diagnosed either radiologically or pathologically, the patient underwent immunosuppressive therapy for 2 months preoperatively.