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    The effects of the microwave oven on pregnant and newborn rat kidneys
    (1997) Inaloz S.S.; Dasdag S.; Aslan A.; Bilici A.; Yayla M.
    Background: The increasing use of microwave radiation for industrial, scientific, medical and domestic purposes has resulted in growing concern about the biological effects of microwaves on man. Objectives: In this study, teratogenic effects of the microwave oven were investigated histologically on pregnant and newborn rat kidneys. Methods: Twenty-four pregnant Wistar- albino rats were separated into three groups (n=8), a control group (sham- exposed) and two experimental groups. The experimental gravid rats were confined in plexiglas cages which were placed next to the closed door of a microwave oven (power-output: 550W). In the first experimental group, the gravid rats were exposed to the microwave oven daily for 15 minutes whereas the gravid rats were exposed daily for 30 minutes in the second experimental group. Results: The physiological dilation of the renal tubules was observed in all dams. There was a positive correlation between the duration of exposure and the severity of necrosis. Necrosis of renal tubules together with normal glomeruli and stromal cells were seen in the first group of litters. Pronounced necrotic renal tissues and adrenal glands were observed only in the fitters of the second group. Conclusion: The teratogenic effects of the MW oven was observed especially in the second group of litters Nevertheless, pregnant users are not exposed to microwave radiation under the same conditions as in our experiment.
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    Omeprazole, nitrendipine, famotidine and stress-induced ulcers
    (1997) Inaloz S.S.; Canberk Y.; Ozaydin M.; Sari I.; Yenilmez E.; Ulak G.; Goral V.
    Background: Omeprazole inhibits gastric acid secretion by blocking the proton pomp of the gastric parietal cell. Nitrendipine is a derivative of dihydropyridine group of calcium channel blockers and administrated for angina and hypertension. Famotidine is one of the newer histamine H2 receptor antagonists and heals gastric and duodenal ulcers by reducing gastric acid output. Objectives: The healing effects of omeprazole, nitrendipine and famotidine on stress-induced gastric ulcers were investigated in rate. Methods: Forty male Wistar-albino rats were separated into five groups (n=8), a control (non-stress) and four experimental (stress) groups. Experimental rats were treated with omeprazole, nitrendipine, famotidine or a placebo after the stresses of starvation and cold-restraint. Results: Macroscopically, the mean area of the affected lesional mucosa was 1/4 of the total gastric mucosa in the famotidine treated group and 1/5 of the total gastric mucosa in the nitrendipine treated group. A considerably decrease was observed in the omeprazole treated group in which the mean area of the lesional mucosa was only in 1/8 of the total gastric mucosa. On microscopic examination, congestive vessels and chronic inflammatory cell infiltrates were significantly reduced in the omeprazole treated group. Tissue regeneration was more prominent in the omeprazole group than me other groups. Conclusion: Omeprazole was found to be superior in terms of the effect on the healing process to nitrendipine and famotidine. Although therapeutic effects of nitrendipine and famotodine were observed, those were less than omeprazole.
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    Öğe
    Omeprazole, nitrendipine, famotidine and stress-induced ulcers [1]
    (1997) Inaloz S.S.; Goral V.; Sari I.
    [No abstract available]
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    Öğe
    Teratogenic effects of cadmium on rat skin
    (1998) Deveci E.; Inaloz H.S.; Inaloz S.S.
    Cadmium is a well-known teratogen in laboratory animals. However, teratogenic effects of cadmium have not been well-described on skin. The purpose of the present study was to assess histologically the teratogenic effects of cadmium on rat skin. After two weeks of confirming pregnancy, Wistar-albino rats (200-220 gr.) were given cadmium chloride intraperitoneally (i.p.) in a dosage of 2 mg/kg (in saline) for five days. Immediately after birth, all litters were anesthetised and several biopsies were taken from skin. In microscopical examination, increased keratinization, mitotic activity and hyperplasia were observed in the epidermal cells. Mitotically active cells were also found in and around the hair follicles. Increased fibrosis and chronic inflammatory cell infiltrate were prominent in the dermal papillae and around the hair follicles. Congestive vessels together with edema and extravasated erythrocytes were noticed in the mid dermis and the around hair follicles. Overall, considerable teratogenic effects of cadmium chloride were found on neonatal rat skin.