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    The effect of hyperbaric oxygen therapy on the survival of random pattern skin flaps in nicotine-treated rats
    (Elsevier Sci Ltd, 2012) Selcuk, Caferi Tayyar; Kuvat, Samet Vasfi; Bozkurt, Mehmet; Yasar, Zeki; Gulsun, Niyazi; Ilgezdi, Savas; Ula, Mahmut
    Previous studies have shown that nicotine increases the risk of necrosis in skin flaps. We investigated the effect of hyperbaric oxygen (HBO2) treatment on the survival of random skin flaps in nicotine-treated rats. Thirty-two SpragueeDawley rats were divided into four groups with eight rats in each group. Group 1 (n=8) was the control, group 2 (n=8) received HBO2 treatment without being exposed to nicotine, group 3 (n=8) received nicotine and group 4 (n=8) received HBO2 treatment with exposure to nicotine. The rats in the nicotine-treated groups were prepared by treating them with nicotine for 28 days. At the end of the 28th day, standard McFarlane-type random skin flaps were lifted from the backs of all the rats. In groups 2 and 4, HBO2 treatment started at the 30th min following the surgery and continued once a day for 7 days. The flap survival rates and histopathological evaluation results related to neovascularisation and granulation tissue formation were significantly better in the HBO2-treated groups (groups 2 and 4) than in the groups that did not receive HBO2 treatment (groups 1 and 3) (p < 0.05). The flap survival rates, neovascularisation and granulation tissue formation were highest in group 2 and lowest in group 3 (p <= 0.001). No significant difference was observed between group 4, which received HBO2 treatment with nicotine exposure, and the control group (group 1) (p > 0.05). In conclusion, our study demonstrates that HBO2 treatment has a positive effect on flap survival in nicotine-treated rats. (C) 2011 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
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    The Effect of Hyperbaric Oxygen Treatment on the Healing of Burn Wounds in Nicotinized and Nonnicotinized Rats
    (Oxford Univ Press, 2013) Selcuk, Caferi Tayyar; Ozalp, Burhan; Durgun, Mustafa; Tekin, Alicem; Akkoc, Mehmet Fatih; Alabalik, Ulas; Ilgezdi, Savas
    The importance of oxygen in wound healing and the negative effects of cigarette smoking have been demonstrated in various studies. In this study, our aim was to investigate the effect of hyperbaric oxygen (HBO2) treatment on wound healing in nicotinized and nonnicotinized rats. The study was conducted on 32 Sprague Dawley rats. The rats were divided into four groups, with eight rats in each: group 1, nonnicotinized rats; group 2, nonnicotinized rats treated with HBO2; group 3, nicotinized rats; and group 4, nicotinized rats treated with HBO2. To prepare the nicotinized groups, the rats were given nicotine for 28 days. At the end of day 28, standard, deep, second-degree to third-degree burns were created on the rats. The HBO2-treated groups underwent HBO2 treatment once a day for 7 days after the creation of the burn damage. All rats were killed 21 days after injury, and the burns were subjected to macroscopic, histopathological, and microbiological evaluation. During this evaluation, the smallest necrotic areas and the lowest rate of fibrosis were observed in group 2. The largest necrotic areas and the highest inflammation and fibrosis rates were observed in the nicotine-treated group 3. When the nicotinized and nonnicotinized groups were compared separately, there was a significant difference in favor of the groups treated with HBO2. Bacterial growth was the highest in the nicotinized group 3, whereas no statistically significant difference was observed among the other groups. We conclude that HBO treatment accelerates the recovery of burn wounds and provides more effective healing by reducing the development of scars both in nicotinized and nonnicotinized rats.