Yazar "Hoşoğlu S." seçeneğine göre listele

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    The evaluation of cultures of endotracheal aspirates and isolated bacteria in the diagnosis of ventilator-associated pneumonia
    (Duzce University Medical School, 2011) Uluğ M.; Çelen M.K.; Geyík M.F.; Hoşoğlu S.; Ayaz C.
    Aim: The aim of this study was to determine the ventilator-associated pneumonia (VAP) agents in isolates from endotracheal aspirate samples obtained from patients in intensive care unit (ICU) on mechanical ventilation and their susceptibility to several antibiotics. Material and Methods: Patients that received mechanical ventilation for longer than 48 hours in the ICU were diagnosed as VAP with the clinical and microbiological criteria, were enrolled in this study. Bacteria isolated from the endotracheal aspiration samples of them were identified by conventional methods and Sceptor systems, and their antibiotic susceptibilities were investigated by the National Committee for Clinical Laboratory Standards (NCCLS). Findings: A total of 72 patients were involved in this study and 84 strains were isolated. Among these patients, 12 (14.3%) had polymicrobial etiologic agent. Most commonly encountered microorganisms were Pseudomonas aeruginosa, Staphylococcus aureus and Acinetobacter spp., respectively. Most of the Gram-negative bacteria were susceptible to imipenem, amikacin and ciprofloxacin. Although methicillin resistant S. aureus rate was found %100, glycopeptides resistance was not found. It was determined that 58 (92%) of the Gram-negative bacteria produced ESBL. Results: As a result, VAP is an important and frequently seen infection in ICU. High resistance rates for antibiotics suggested that the treatment of the empirical antibiotics recommended for VAP cases should be updated according to the surveillance data. © 2011 Düzce Medical Journal.
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    Retrospective evaluation of brucellosis cases inhabiting in Mus province
    (2006) Şit D.; Kadiroğlu A.K.; Kayabaşi H.; Hoşoğlu S.
    The aim of this study was to evaluate the brucellosis patients inhabiting in Mus province, in Eastern Anatolia of Turkey, retrospectively. The mean age of the patients (n: 87) was 38.1±12.4 years, and 45% of them were female. The transmission route was the consumption of unpasteurized fresh cheese (in 85%), and unboiled milk (in 45%). The most common symptoms were recorded as chills (89%), fever (87%), and arthralgia (81%). Splenomegaly (71%) and hepatomegaly (63%) were the predominant physical examination signs. Diagnosis was made based on the clinical features and positive Rose-Bengal test result (93%), however, blood cultures could not be performed due to insufficient laboratory equipment. In 92% of the patients at least one complication has been detected indicating delayed admission to the hospital, while the most common complications were sacroileitis (79%) and spondylitis (44%). Streptomycin+doxycyclin, streptomycin+doxycyclin+ ciprofloxacin, and streptomycin+doxycyclin+ rifampicin combination therapies were used in 62%, 24% and 14% of the patients, respectively, for six weeks, resulting with complete cure.
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    Risk factors for central venous catheter-related bloodstream infections
    (EDIMES Edizioni Medico Scientifiche, 2019) Bekçibaşi M.; Dayan S.; Aslan E.; Kortak M.Z.; Hoşoğlu S.
    Our study aimed to identify the risk factors playing a role in central venous catheter-related bloodstream infections (CR-BSI) in a tertiary large volume university hospital. The current prospective clinical trial was conducted in a university hospital with 1400 beds. All demographic data, length of hospital stay, coexisting diseases, features of catheters used, invasive diagnostic and therapeutic procedures and all antibiotics used in patients with CVCs were recorded. A total of 356 CVCs inserted in 281 patients were followed up for 5667 catheter days. The mean duration of catheterization was recorded as 15.9±12.7days. CR-BSI was detected in 46 (12.9%) patients. The incidence of CR-BSI was found to be 8.12 in 1000 catheter days. Advanced age and longer duration of catheterization were found to be independent risk factors for the development of CR-BSI in multivariate analysis. Coagulase-negative staphylococci (15.2%), Candida spp (13%) and Klebsiella pneumoniae (13%) were the agents most frequently isolated. © 2019, EDIMES Edizioni Medico Scientifiche. All rights reserved.