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    The All-Seeing Needle Instead of the Veress Needle in Pediatric Urologic Laparoscopy
    (Mary Ann Liebert, Inc, 2013) Silay, Mesrur Selcuk; Tepeler, Abdulkadir; Sancaktutar, Ahmet Ali; Kilincaslan, Huseyin; Altay, Bulent; Erdem, Mehmet Remzi; Hatipoglu, Namik Kemal
    Purpose: To investigate the feasibility of the all-seeing needle for safe entry and creation of pneumoperitoneum in pediatric urologic laparoscopy. Patients and Methods: A total of 14 children underwent various transperitoneal urologic laparoscopic procedures. The all-seeing needle, which is 4.85F in diameter, was used for safe entry into the abdominal cavity at the site of the umblicus in all cases. The microoptic was integrated with the light system and connected via a zoom ocular enabling direct visualization of the layers between the skin and the peritoneal cavity. Once the intraperitoneal access was obtained, CO2 pneumoperitoneum was created from one port of the three-way connector attached to the proximal part of the needle. Then the laparoscopic trocars were placed under vision of the microoptical system. Results: Mean age of the children was 4.52.9 years. In all children, the all-seeing needle was safely introduced into the abdominal cavity under direct vision. Then, CO2 pneumoperitoneum was succesfully performed. The mean time for optical puncture was calculated as 1.1 +/- 0.8 minutes. No complication was encountered during the introduction of the needle, creation of the pneumoperitoneum, and placement of the trocars. Conclusions: The all-seeing needle appears to be beneficial in safe entry and for creating pneumoperitoneum in laparoscopic pediatric urology cases. It eliminates the disadvantages of the Veress needle, which is blunt insertion, and may possibly prevent complications.
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    An Alternative and Inexpensive Percutaneous Access Needle in Pediatric Patients
    (Elsevier Science Inc, 2012) Penbegül, Necmettin; Soylemez, Haluk; Bozkurt, Yasar; Sancaktutar, Ahmet Ali; Bodakci, Mehmet Nuri; Hatipoglu, Namik Kemal; Atar, Murat
    INTRODUCTION The most important factor that increases the cost of percutaneous surgery is the disposable instruments used for the surgery. In this study we present the advantages of using an intravenous cannula instead of a percutaneous access needle for renal access. TECHNICAL CONSIDERATIONS Recently, percutaneous stone surgery has grown in use in pediatric cases and is considered a minimally invasive surgery. The most important step in this surgery is access to the renal collecting systems. Although fluoroscopy has been used frequently at this stage, the use of ultrasound has recently increased. During percutaneous accesses under all types of imaging techniques, disposable 11- to 15-cm-long 18-ga needles are used. In pediatric cases, these longer needles are difficult to use. Using disposable materials in percutaneous nephrolithotomy increases the cost of the procedure. Therefore, we asserted that percutaneous access especially in pediatric cases could be performed using a 16-ga intravenous cannula (angiocath). Indeed, percutaneous access was performed successfully, especially in pediatric preschool patients. Shorter needle length, easy skin entry, comfort of manipulation, clear visualization of the metal needle on ultrasound, and wide availability can be considered advantages of this method. The angiocath is also less expensive than a percutaneous access needle. CONCLUSION Angiocath is inexpensive, easily available, and practical, and it is the shortest needle to perform percutaneous access in pediatric patients. UROLOGY 80: 938-940, 2012. (C) 2012 Elsevier Inc.
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    Antioxidant Signal and Kidney Injury Molecule-1 Levels in Shockwave Lithotripsy Induced Kidney Injury
    (Mary Ann Liebert, Inc, 2014) Hatipoglu, Namik Kemal; Evliyaoglu, Osman; Isik, Birgul; Bodakci, Mehmet Nuri; Bozkurt, Yasar; Sancaktutar, Ahmet Ali; Soylemez, Haluk
    Purpose: Shockwave lithotripsy (SWL) induces acute kidney injury (AKI) that extends from the papilla to the outer cortex by causing ischemia and the production of nephrotoxic agents. Direct ischemic damage and the generation of free radicals cause injury to the proximal tubular cells. Kidney injury molecule-1 (KIM-1) is a transmembrane glycoprotein that is upregulated in proximal tubular cells after ischemic or nephrotoxic injury and is not expressed in healthy kidneys. We evaluated the extent of free radical production in response to SWL by measuring urinary total antioxidant capacity (TAC) and total oxidant status (TOS). Furthermore, we investigated the severity of SWL-induced kidney injury by measuring KIM-1 expression levels. Patients and Methods: The study population comprised 30 patients who were carefully selected and 30 age and sex matched control subjects. All patients received the same SWL procedure. Midstream urine samples were collected from patients before SWL and at 120 minutes after SWL. Urine KIM-1 levels were measured by enzyme-linked immunosorbent assay, and TAC and TOS were measured via spectrophotometry. Results: Mean levels of TAC (2.880.56mmolTxEq/L),TOS (8.27 +/- 1.57molH(2)O(2)Eq/L), and KIM-1 (0.55 +/- 0.08ng/mL) before SWL were not significantly different from mean TAC, TOS, and KIM-1 levels measured from the control group at 2.81 +/- 0.42mmolTxEq/L, 10.73 +/- 1.4molH(2)O(2)Eq/L, and 0.51 +/- 0.07ng/mL, respectively. Two hours after SWL, mean urine TAC levels (2.81 +/- 0.85mmolTxEq/L, P=0.02) were decreased and mean KIM-1 expression (0.85 +/- 0.11ng/mL, P=0.01) was significantly increased, but there was no significant difference in mean TOS levels (11.24 +/- 1.9molH(2)O(2)Eq/L, P=0.627) compared with the control group. Conclusions: The increased burden of free radical oxidants in the setting of decreasing antioxidant capacity may be one of the initial indicators of AKI after SWL. Moreover, KIM-1 demonstrates great potential as an early and noninvasive biomarker of SWL-induced kidney injury.
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    ANTIOXIDANT SIGNAL AND KIM-1 LEVELS IN ESWL INDUCED KIDNEY INJURY
    (Mary Ann Liebert, Inc, 2012) Hatipoglu, Namik Kemal; Evliyaoglu, Osman; Bodakci, Mehmet Nuri; Atar, Murat; Penbegül, Necmettin; Soylemez, Haluk; Sancaktutar, Ahmet Ali
    [Abstract Not Available]
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    Association of microRNA-related gene polymorphisms and idiopathic azoospermia in a south-east Turkey population
    (Taylor & Francis Ltd, 2017) Ay, Ozlem Izci; Balkan, Mahmut; Erdal, Mehmet Emin; Rustemoglu, Aydin; Atar, Murat; Hatipoglu, Namik Kemal; Bodakci, Mehmet Nuri
    MicroRNAs (miRNAs) are small conserved non-coding RNA molecules that post-transcriptionally regulate gene expression. Although it is reported in many studies that there are associations between alterations of miRNA homeostasis and pathological conditions such as cancer, psychiatric and neurological diseases, cardiovascular disease and autoimmune disease, the effects of common genetic variants of these genes on male infertility are unclear. To better understand this effect, we performed a case-control study including a total of 108 infertile men with idiopathic azoospermia and 125 fertile control subjects. Real-time polymerase chain reaction was used to genotype six single-nucleotide polymorphisms (SNPs) of microRNA biogenesis pathway genes and the associations between individual and combined genotypes and idiopathic azoospermia were analysed. The results showed significant difference between the individual AA genotype frequency of the GEMIN3 (rs197388) gene in the patient and control groups, indicating that the AA genotype may be considered as indicative of a higher predisposition to idiopathic azoospermia. The combined genotype analysis, including six SNPs, revealed statistically significant differences between the patients and control subjects for some combinations. For example, the frequency of genotype distributions of the AA\CA-CC-TT-AT genotype combination for the XPO5-RAN-DICER1GEMIN3 combined loci was significantly different, and it may be considered a predisposition to idiopathic azoospermia. According to the obtained results, both individual and combined genotypes of SNPs from miRNA genes may be used to predict the risk of male infertility with idiopathic azoospermia.
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    A case of micro-percutaneous nephrolithotomy with macro complication
    (Aves Yayincilik, Ibrahim Kara, 2015) Dede, Onur; Utangac, Mazhar; Dagguli, Mansur; Hatipoglu, Namik Kemal; Sancaktutar, Ahmet Ali; Bodakci, Mehmet Nuri
    Percutaneous nephrolithotomy is accepted as the standard management approach for kidney stones that are either refractory to extracorporeal shock wave lithotripsy or are >2 cm in diameter. The recently developed micro-percutaneous nephrolithotomy (microperc) technique provides intrarenal access under full vision using an optic instrument with a smaller calibration. A lesser amount of bleeding has been reported with the use of this method. Here we present a case of a bleeding complication on postoperative day 15 after a microperc procedure used to treat a left kidney stone. The complication led to retention of bloody urine in the bladder and required transfusion of 5 units of whole blood.
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    Chronic Periodontitis and Erectile Dysfunction
    (Wiley-Blackwell, 2013) Bodakci, Mehmet Nuri; Hatipoglu, Namik Kemal; Ozbey, Isa
    [Abstract Not Available]
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    A Comparison of 2 Percutaneous Nephrolithotomy Techniques for the Treatment of Pediatric Kidney Stones of Sizes 10-20 mm: Microperc vs Miniperc
    (Elsevier Science Inc, 2015) Karatag, Tuna; Tepeler, Abdulkadir; Silay, Mesrur Selcuk; Bodakci, Mehmet Nuri; Buldu, Ibrahim; Daggulli, Mansur; Hatipoglu, Namik Kemal
    OBJECTIVE To compare outcomes of micro-percutaneous nephrolithotomy (PNL; microperc) with mini-PNL (miniperc) in the treatment of pediatric renal stones of sizes 10-20 mm. MATERIALS AND METHODS Patients aged <18 years who underwent PNL for renal stones of sizes 10-20 mm between August 2011 and March 2014 in 3 referral centers were reviewed retrospectively. Patients were evaluated in the following 2 groups: microperc (group 1) and miniperc (group 2). Demographics and perioperative parameters (fluoroscopy and operation time, hemoglobin drop, and stone-free and complication rates) were retrospectively analyzed. RESULTS A total of 119 patients were evaluated, including group 1 (n = 56) for microperc and group 2 (n = 63) for miniperc. We found mean stone sizes as 13.4 +/- 3.4 and 14.8 +/- 3.7 mm in the groups, respectively (P = .046). Mean operation and fluoroscopy times were 57.1 +/- 31.2 minutes and 132.4 +/- 92.5 seconds in the microperc group and 68.9 +/- 36.7 minutes and 226.2 +/- 166.2 seconds in the miniperc group, respectively (P = .110 and P <. 001). Stone-free rates were similar in both groups (82.1% vs 87.3%; P = .433 and 92.8% vs 93.6%; P = 0673) on postoperative day 1 and at first-month follow-up. The mean hemoglobin drop in group 2 differed from that in group 1 significantly (P <. 001). The difference of average hospitalization times was statistically significant (43.0 +/- 15.4 vs 68.5 +/- 31.7 hours; P <. 001). CONCLUSION Our outcomes show that microperc may be preferred as an alternative to mini-PNL for the treatment of pediatric kidney stones of sizes 10-20mmwith comparable success and complication rates, as well as shorter hospitalization and fluoroscopy times. (C) 2015 Elsevier Inc.
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    Comparison of a 4.5 F semi-rigid ureteroscope with a 7.5 F rigid ureteroscope in the treatment of ureteral stones in preschool-age children
    (Springer, 2012) Atar, Murat; Sancaktutar, Ahmet Ali; Penbegül, Necmettin; Soylemez, Haluk; Bodakci, Mehmet Nuri; Hatipoglu, Namik Kemal; Bozkurt, Yasar
    The aim of this study was to compare the success and complication rates of a 4.5 F ureteroscope with a 7.5 F ureteroscope in the treatment of urolithiasis in preschool-age children. We retrospectively reviewed 69 ureteroscopy (URS) procedures in a pediatric population (40 boys, 29 girls). We divided the patients into two groups according to the type of ureteroscope used: group 1 (n = 42, Storz 7.5 F) and group 2 (n = 27, Wolf 4.5 F). We statistically compared all the procedures performed in both groups regarding patient age, complication rates, whether the procedure was therapeutic, and whether we used a guidewire. Additionally, in cases with ureteral stones, we also compared the stone clearance rate and the necessity of X-ray imaging between the two groups. The mean patient age was 56.04 months in group 1 and 47.48 months in group 2 (p = 0.057). The stone-free rate was 78.6 % in group 1 and 92.6 % in group 2 (p > 0.05). However, when we compared the stone-free rates for patients younger than 3 years, the rate was 66.7 % in group 1 and 93.8 % in group 2 (p < 0.05). The difference was not statistically significant for patients between the ages of 4 and 7 years. The success and failure rates revealed better outcomes for treatment of ureteral stones with a 4.5 F ureteroscope. We recommend the use of the mini-ureteroscope, especially in infants and preschool-age children.
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    Comparison of Monoplanar and Biplanar Access Techniques for Percutaneous Nephrolithotomy
    (Mary Ann Liebert, Inc, 2015) Dede, Onur; Bas, Okan; Sancaktutar, Ahmet Ali; Daggulli, Mansur; Utangac, Mazhar; Penbegül, Necmettin; Hatipoglu, Namik Kemal
    Purpose: The aim of this study was to compare the positive aspects and complications of monoplanar and biplanar access techniques used in percutaneous nephrolithotomy (PCNL) based on the modified Clavien complication grading system. Patients and Methods: The data from patients who underwent PCNL using either monoplanar access (group 1) or biplanar access (group 2) techniques were analyzed retrospectively. For the biplanar technique, puncture is adjusted based on different fluoroscopic projections, including vertical and 30 degree positions. For the monoplanar technique, a C-arm fluoroscope was brought into vertical position, the collecting system was visualized with a contrast agent, and the most appropriate calix was selected to extract the targeted stone. Results: The monoplanar technique was performed for renal access in 310 patients (group 1), and the biplanar technique was used for renal access in 351 patients (group 2). There were no statistically significant differences between the two groups with regard to demographic data. The mean puncture time was significantly lower in group 1 (monoplanar) when compared with that of group 2 (biplanar, P=0.04). The overall success rates of the monoplanar and biplanar groups were 88% and 89% (including clinically insignifican residual fragments in 9% and 7%), respectively (P>0.05), and the complication rates of both groups were similar. Conclusion: The monoplanar access technique, which is safe to use, decreases puncture time, minimizes the surgeon's direct exposure time to radiation, and has similar success rates as the biplanar access technique.
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    Comparison of pneumatic and laser lithotripsy in the treatment of pediatric ureteral stones
    (Elsevier Sci Ltd, 2013) Atar, Murat; Bodakci, Mehmet Nuri; Sancaktutar, Ahmet Ali; Penbegül, Necmettin; Soylemez, Haluk; Bozkurt, Yasar; Hatipoglu, Namik Kemal
    Objective: To compare the effectiveness and safety of pneumatic and holmium: YAG laser lithotripters in the treatment of pediatric ureterolithiasis. Patients and methods: Medical records of patients treated using pneumatic (PL) (n = 29) or laser (LL) (n = 35) lithotripter between 2009 and 2011 were retrospectively analysed. The patients were evaluated with respect to age, gender, stone size, complications, and stone-free rates 1 month after the operation. Results: For the PL and LL groups, mean ages (8.8 +/- 3.4 and 8.3 +/- 3.5 years), male/ female ratios (19:10 and 22:13) and stone locations were similar (p > 0.05). Mean stone sizes were 55.6 mm(2) and 47.6 mm(2) in the PL and LL group, respectively, with no statistically significant difference (p = 0.850). Mean operative times were 20.5 min in the PL group and 25.2 min in the LL group, with a statistically significant difference (p = 0.020). Stone-free rates 1 month after intervention were 79% in the PL group and 97% in the LL group (p = 0.022). Stone migration was detected in the PL group (n = 6) and in the LL group (n = 1). No major complication was found in either group. Conclusion: In the ureteroscopic treatment of pediatric ureterolithiasis, both pneumatic and laser lithotripters are effective and successful. However, laser lithotripsy has a higher stone-free rate and lower complication rate. (C) 2012 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved.
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    Comparison of Shockwave Lithotripsy and Microperc for Treatment of Kidney Stones in Children
    (Mary Ann Liebert, Inc, 2013) Hatipoglu, Namik Kemal; Sancaktutar, Ahmet Ali; Tepeler, Abdulkadir; Bodakci, Mehmet Nuri; Penbegül, Necmettin; Atar, Murat; Bozkurt, Yasar
    Purpose: We aimed to compare the outcomes of microperc and shockwave lithotripsy (SWL) for treatment of kidney stones in children. Patients and Methods: The medical records of 145 patients under the age of 15 years with opaque and single kidney stones treated with either SWL or microperc were retrospectively reviewed. Both groups were compared in terms of fluoroscopy and operative time, re-treatment, complications, success rate, and secondary and total number of procedures. Results: Microperc and SWL were performed on 37 and 108 pediatric patients, respectively. The mean age of the patients was 5.914.03 years (1-15) and 8.43 +/- 4.84 (1-15) years in the SWL and microperc groups, respectively (P=0.004). The mean stone size was 11.32 +/- 2.84 (5-20) mm in the SWL group and 14.78 +/- 5.39 (6-32) mm in the microperc group (P<0.001). In the SWL group, 31 (28.7%) patients underwent a second SWL session and 6 (5%) had a third session. Finally, 95 (88%) patients were stone free at the end of the SWL sessions. In the microperc group, the stone-free rate was 89.2% in a single session (P=0.645). The mean duration of hospitalization was 49.2 +/- 12.3 (16-64) hours in the microperc group and 8.4 +/- 2.3 (6-10) hours per one session in the SWL group (P<0.001). The fluoroscopy time was significantly longer in the microperc group compared with the SWL group (147.3 +/- 95.3 seconds vs 59.6 +/- 25.9 seconds, P<0.001). The rate of requirement for an auxiliary procedure was higher in the SWL group than in the microperc group. The overall complication rates for the microperc and SWL groups were 21.6% and 16.7%, respectively (P=0.498). Conclusions: The results of our study demonstrate that microperc provides a similar stone-free rate and a lower additional treatment rate compared with SWL in the treatment of kidney stone disease in children.
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    Conventional monopolar transurethral resection of prostate in patients with large prostate (?80 grams)
    (Polish Urological Assoc, 2013) Yucel, Mehmet; Aras, Bekir; Yalcinkaya, Soner; Hatipoglu, Namik Kemal; Aras, Erol
    Introduction. Transurethral resection of the prostate (TURP) is still regarded as the gold standard for the treatment of lower urinary tract symptoms (LUTS) secondary to benign prostate obstruction in prostates between 30 and 80 mL. Endoscopic treatment of large prostate is not adequately discussed in literature. Our objective was to evaluate the efficacy and safety of TURP in large prostate glands (>= 80 ml) in patients with BPH. Material and methods. From May 2004 to September 2012, 62 patients with high volume of BPH (>= 80 ml) treated with TURP by single surgeon, were evaluated retrospectively. Perioperative and postoperative full blood count and serum electrolytes, complications, operative time, weight of resected prostate tissue, time for catheter removal, and hospitalization time were recorded. Conventional TURP was performed using a standard technique. Results. The mean PSA levels and prostate volumes were 8 +/- 5.38 ng/ml and 90.93 +/- 13.95 gm, respectively. The mean operating time was 55.96 +/- 8.04 minutes. The mean amount of tissue resected was 52.21 +/- 7.59 gm. Compare with baseline, there were significant improvements in International Prostate Symptom Score (IPSS), Quality of Life (QoL), maximum urinary flow rate (Q(max)), and postvoiding residual urine after surgery. There was no major bleeding complication. There was no TUR syndrome or intraoperative death. Requiring re-catheterization was detected for 3 (4.8%) patients. Transient urge incontinence was observed for 3 (4.8%) patients. Bulbar urethral stricture was developed for 2 (3.2%) patients. Conclusions. Morbidity of the TURP is decreased with the technological improvements. Conventional monopolar TURP can be effectively performed in large prostate (= 80 mL) with the experience.
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    Debate on monoplanar percutaneous nephrolithotomy
    (Springer, 2013) Hatipoglu, Namik Kemal; Bodakci, Mehmet Nuri; Penbegül, Necmettin; Bozkurt, Yasar; Sancaktutar, Ahmet Ali; Atar, Murat; Soylemez, Haluk
    [Abstract Not Available]
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    Determining standard criteria for tubeless PCNL
    (Springer, 2014) Daggulli, Mansur; Soylemez, Haluk; Bodakci, Mehmet Nuri; Hatipoglu, Namik Kemal
    [Abstract Not Available]
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    Does aging affect the outcome of percutaneous nephrolithotomy?
    (Springer, 2015) Buldu, Ibrahim; Tepeler, Abdulkadir; Karatag, Tuna; Bodakci, Mehmet Nuri; Hatipoglu, Namik Kemal; Penbegül, Necmettin; Akman, Tolga
    To investigate whether aging affects surgical outcomes by comparing the results of two patient groups undergoing PNL: those over 60 and those under 60. A retrospective screen was made for patients undergoing conventional PNL surgery for renal stones performed in two separate centers between 2010 and 2013. 520 patients included were classified into age groups: patients aged 18-59 comprised Group-1 and those aged over 60 comprised Group-2. Those between 60-69 years (sexagenarian) were assigned to Group-2a; 70-79 years (septuagenarian) to Group-2b; and 80-89 years (octogenarian) to Group-2c. Patients' demographic characteristics (accompanying comorbidities, ASA scores, body mass indices and stone size) and perioperative values (duration of surgery and hospital stay, success and complication rates) were compared between the groups. Mean stone size was similar in groups (30.1 +/- 15.5 vs. 31.5 +/- 15.4 mm, p = 0.379). The mean ASA value for the patients in Group-1 was 1.61; significantly lower than that in the other groups (p = 0.000). The level of accompanying comorbidities in Group-1 was significantly lower than that of the other groups (p = 0.000). The mean duration of surgery, postoperative hematocrit drop, complication and success rate were statistically similar in Groups 1 and 2 (p = 0.860, p = 0.430, p = 0.7, and p = 0.66, respectively). The duration of hospital stay was significantly shorter in the patients in Group-1 compared to those in Group-2 (p = 0.008). In experienced hands, PNL can be safely and reliably performed in the treatment of renal stones in elderly patients.
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    THE EDUCATION OF PEDIATRIC ENDOUROLOGY: THE STATUS OF TURKISH UROLOGY RESIDENTS
    (Mary Ann Liebert, Inc, 2012) Sancaktutar, Ahmet Ali; Yildirim, Kadir; Bodakci, Mehmet Nuri; Yavuz, Sevgi; Hatipoglu, Namik Kemal; Soylemez, Haluk; Penbegül, Necmettin
    [Abstract Not Available]
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    Effectiveness and safety of ureteroscopy in pregnant women: a comparative study
    (Springer, 2013) Bozkurt, Yasar; Soylemez, Haluk; Atar, Murat; Sancaktutar, Ahmet Ali; Penbegül, Necmettin; Hatipoglu, Namik Kemal; Bodakci, Mehmet Nuri
    The aim of this study was to investigate the efficacy and safety of ureteroscopy (URS) in pregnant patients compared with non-pregnant patients. We reviewed the cases of 41 pregnant and 62 non-pregnant women who developed ureteral stones and were treated with URS in our center between April 2005 and September 2011. A semi-rigid 9.5 F ureteroscope was used. The calculi were fragmented with pneumatic lithotripsy or a holmium laser, and if necessary, a double-J (JJ) stent was inserted during the procedure. Among the pregnant women, the mean gestation period was 23.22 +/- 4.61 weeks (range 13-34), and the mean number of pregnancies per patient was 3 +/- 2.02 (range 1-10). The mean ages of the pregnant and non-pregnant patients were 27.41 +/- 5.79 and 28.54 +/- 7.94 years, respectively (p = 0.734). There were no statistically significant differences in stone localization, anesthesia type, stone diameter, methods of stone manipulation, JJ stent insertion rate, hospitalization length, or operative times between the two groups. For pregnant and non-pregnant patients, the stone-free rates achieved in a single session were 87.8 and 85.5 %, respectively (p = 0.737). There was no statistically significant difference in preoperative and postoperative complication rates between the two groups. The positive urine culture rate was statistically significantly higher for pregnant patients than non-pregnant patients (29.3 vs. 11.3 %; p = 0.021). We did not observe any serious obstetric complications. URS is a safe and reasonable treatment option for pregnant patients with ureteral stones refractory to medical treatment during pregnancy.
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    EFFECTIVENESS OF 4.5 F SEMIRIGID URETEROSCOPE (MINI-URS) IN THE MANAGEMENT OF URETERAL STONES IN CHILDREN YOUNGER THAN 3 YEARS OF AGE
    (Mary Ann Liebert, Inc, 2012) Sancaktutar, Ahmet Ali; Atar, Murat; Soylemez, Haluk; Bozkurt, Yasar; Hatipoglu, Namik Kemal; Penbegül, Necmettin; Bodakci, Mehmet Nuri
    [Abstract Not Available]
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    The Effects of Caffeic Acid Phenethyl Ester and Ellagic Acid on the Levels of Malondialdehyde, Reduced Glutathione and Nitric Oxide in the Lung, Liver and Kidney Tissues in Acute Diazinon Toxicity in Rats
    (Medwell Online, 2011) Alp, Harun; Aytekin, Ismail; Atakisi, Onur; Hatipoglu, Namik Kemal; Basarali, Kemal; Ogun, Metin; Buyukbas, Sadik
    The aim of this study was to investigate the effects of Caffeic Acid Phenethyl Ester (CAPE) and Ellagic Acid (EA) on acitivities of Malondialdehyde (MDA), reduced Glutathione (GSH) and Nitric Oxide (NO) in rat lung, liver and kidney tissues in acute Diazinon (DI) toxicity. Six groups of 6 Sprague Dawley rats were used comprising control, CAPE, EA, DI control, DI+CAPE and DI+EA. Tissue samples were analysed for GSH, MDA and NO levels in lung, liver and kidney tissues. Biochemical parameters were measured colormetrically by spectrophotometer. Control, CAPE and EA groups showed no statistically significant difference whereas DI+medication groups revealed that CAPE and EA increased the level of GSH in liver tissue by blocking the DI effect. NO levels in lung, liver and kidney tissues were significantly increased by DI but CAPE and EA attenuated those levels. In DI+medication groups, MDA levels showed no significant change in kidney and liver tissues but in lung tissues, CAPE and EA reduced the MDA level by blocking the DI effect. It was concluded that CAPE and EA which showed similar effects to each other could be used for protection and support against oxidative stress caused by acute DI intoxication.