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    The possible association of polymorphisms in MTHFR, MTRR, and MTHFD1 genes with male infertility
    (2013) Balkan M.; Atar M.; Erdal M.E.; Yildiz I.; Hatipoğlu N.K.; Bodakç M.N.; Ay O.I.
    Objective: The aim of this study was to investigate the association of the methylenetetrahydrofolate reductase (MTHFR), methionine synthase reductase (MTRR), and methylenetetrahydrofolate dehydrogenase (MTHFD1) polymorphisms in idiopathic infertile men and fertile men. Materials and Methods: Case-control study comprising a total of 233 individuals including 108 idiopathic infertile men with nonobstructive azoospermia and 125 fertile men as control. MTHFR C677T, A1298C; MTRR A66G; and MTHFD1 G1958A polymorphisms were studied by Real-Time PCR System. The results were analyzed statistically and a P value <. 05 was considered significant. The Chi square test was used to analyze the genotype distributions of polymorphisms. Results: Single-marker analysis revealed that none of the four polymorphisms was significantly associated with nonobstructive azoospermia. All groups were tested for Hardy-Weinberg equilibrium and the deviation from the Hardy-Weinberg equilibrium takes place for MTHFR C677T (P < 0.05) a combination of controls and infertile group. We also performed a multifactor dimensionality reduction (MDR) analysis to investigate any potential epistatic interactions among the four polymorphisms and male infertility. We found a synergistic interaction between some polymorphisms (P < 0.05). Conclusion: Our findings therefore suggest no individual but interactive association between four prominent folate metabolism pathway markers and male infertility among population in the Southeast Turkey. © 2013 Japan International Cultural Exchange Foundation & Japan Health Sciences University.
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    Urinary expression of acute kidney injury biomarkers in patients after RIRS: It is a prospective, controlled study
    (E-Century Publishing Corporation, 2015) Dede O.; Dağguli M.; Utanğaç M.; Yuksel H.; Bodakcı M.N.; Hatipoğlu N.K.; Sancaktutar, Ahmet Ali
    Objective: To evaluated the damage effects of retrograde intra-renal surgery (RIRS) on kidney tissue by measuring kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), N-acetyl-?-D-glucosaminidase (NAG), liver-type fatty acid binding protein (LFABP) expression. Material and methods: We enrolled thirty consecutive patients (Group 1) who underwent RIRS that presented with renal calculi size < 2 cm. Forty-seven control patients (Group 2) with no signs or symptoms of urogenital disease were also enrolled for this study. Patients urine KIM-1, NGAL, NAG, and LFABP and creatinine levels were determined before the surgery, 2 hours after the surgery, and 24 hours after the surgery. Results: Demographic data were established and found to be similar between the two groups. Two hours after the surgery KIM-1/Cr and NGAL/Cr levels had increased significantly in urine compared to levels before the surgery (P:0.04, P:0.02 respectively) and decreased 24 hours after the surgery. The NAG/Cr and LFABP/Cr levels did not change significantly after the surgery. Conclusion: According to acute kidney injury (AKI) markers, this study is suggests that RIRS is a safe method, KIM-1/Cr and NGAL/Cr levels were increased first 2 hours but returned to initial levels within 24 hours after the surgery. © 2015, E-Century Publishing Corporation. All rights reserved.