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    Cytotoxic potential of selenium nanoparticles (SeNPs) derived from leaf extract of Mentha longifolia L.
    (Gültekin ÖZDEMİR, 2024) İpek, Polat; Baran, Ayşe; Hatipoğlu, Abdülkerim; Baran, Mehmet Fırat
    The search for alternative methods in cancer treatments has been going on for many years. In the current study conducted for this purpose, selenium nanoparticles (ML-SeNPs) were produced from the aqueous leaf extract of Mentha longifolia L. easily and inexpensively, without harming the environment. The anticancer potential of ML-SeNPs on glioblastoma cell (U373), osteosarcoma cell (U2OS), and healthy retinal pigment epithelial cell (RPE-1) lines was determined by MTT (3-(4,5-dimetiltiazol-2-il)-2,5-difeniltetrazolium bromid) test. For the test, ML-SeNPs were applied at 100, 300, and 600 µg/mL levels and interaction was provided for 24 and 48 hours. The survival rates (%) in RPE-1, U373, and U2OS cell lines in the 24-hour application were 107.49-98.89, 97.66-86.82, and 87.81-83.37, respectively. The viability rates (%) of the cells in 48 hours of application were 72.27-87.39, 68.17-73.48, and 81.00-84.67, respectively. In general, it was discovered that the cytotoxic effect of ML-SeNPs on RPE-1, U373, and U2OS cell lines was greater at low doses and increased over time. In-vivo studies that support the antiproliferative action of ML-SeNPs may boost the prospect of using them as therapeutic agents in potential cancer treatment procedures in the following years.
  • Küçük Resim
    Öğe
    Identify of macro and trace elements in grain  of some barley varieties and interpretation zwith biplot technique
    (University of Montenegro, 2021) Düzgün, Mehmet; Kendal, Enver; Düz, Mehmet Zahir; Hatipoğlu, Abdülkerim
    The purpose of this study was to determine the content of some macro and trace elements in grain of spring barley cultivars, and to state the relationships between those elements. In this study macro and trace elements (Ca, K, Mg, Fe, Zn, Mn, Si, Sn, Cu, Cr, Cd, Ni, V, Pb, As and Se) of barley cultivars were determined by inductively coupled plasma optic emission spektometry (ICP-OES) using grain. The grain samples were digested by microwave system, as well as. As and Se were determined by hydride system. The result of study showed that the content Si of barley cultivars are quite high, however, the concentrations toxic heavy metals of Cd, Pb and as were determined to be below the limit values. The biplot indicated that three group occurred among macro and trace element and the correlation of Zn with Sn, Cr with Ca and Fe, Ca with Fe and Pb was significant and positively, while V with Si was significant and negatively. On the other hand, the study showed that Samyeli is the best cultivar based on macro and trace element concentrations and this variety can be used in animal husbandry.