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Öğe Assessment of thyroid function in children aged 1-13 years with beta-thalassemia major(Brieflands, 2011) Pirinççioğlu A.G.; Deniz T.; Gökalp D.; Beyazit N.; Haspolat K.; Söker M.Objective: Hypothyroidism usually appears in the second decade of life and is thought to be associated with iron overload in patients with thalassemia major. This study aimed to evaluate thyroid dysfunctions in patients with beta-thalassemia major and to see if they appear in the earlier period of life. Methods: Thyroid function and iron load status were evaluated in 90 children with a mean age of 7.17±3.78 years with beta-thalassemia major by measuring serum free thyroxin (FT4), serum free triiodothyronine (FT3), total thyroxin (T3), serum total triiodothyronine (T4), thyroid-stimulating hormone (TSH) and ferritin levels from serum of patients admitted to the Pediatric Department, Faculty of Medicine University of Dicle between March 2005 and July 2009. A control group formed from an age-sex matched healthy children with a mean age of 6.98±3.66 years was also included. A standard thyrotropin releasing hormone test was applied to 3 patients who had high TSH levels and were classified as subclinical primer hypothyroidism. The study was designed according to the Declaration of Helsinki and informed consent was obtained from the parents of all participants. Findings: All thyroid parameters in patients were in the normal ranges compared with the controls except three of them which had high TSH levels. Serum ferritin level (2703±1649 ng/mL) in patients was significantly higher than in controls (81.5±15.5 ng/mL). Conclusion: The work implies that hypothyroidism could be even seen in the first decade of life in patients with beta-thalassemia major in spite of improved hematological cares. © 2011 by Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, All rights reserved.Öğe Cardiac troponin-I as a marker of myocardial dysfunction in children with septic shock(SMW supporting association, 2004) Gurkan F.; Alkaya A.; Ece A.; Haspolat K.; Boşnak Mehmet; Bilici M.; Kervancioglu M.Objectives: Cardiac depression is well known in severe sepsis and septic shock. Our aim was to investigate the incidence of myocardial ischaemia as shown by cardiac troponin I (cTnI) levels in patients with septic shock and to evaluate the correlation with myocardial dysfunction measured by echocardiography. Methods: The study was performed in the paediatric intensive care unit in Dicle University Hospital, Turkey, between January 2001 and December 2002. Patients in septic shock, with a mean age of 6.4 ± 2.8 months, were simultaneously submitted to a two-dimensional echocardiogram and biochemical investigation on admission. Results: The mean serum cTnI level of the patients was 3.1 ± 2.6 ng/ml (0.01-9.80 ng/ml) and the mean LVEF value was calculated as 48% ± 11%. 21 patients (75%) had a cTnI level ?0.6 ng/ml, and 15 patients (54%) had a LVEF <0.5. For cTnI levels ?0.6 ng/ml, sensitivity and specificity were 93.3% and 46.2%, and positive and negative predictive values were 66.7% and 85.7% respectively. For cTnI values ?2.0 ng/ml, sensitivity and specificity were 86.7% and 76.9%, and positive and negative predictive values were 81.3% and 83.3%, respectively. There was a statistically significant relationship between LV dysfunction and cTnI positivity (r2 = 0.316, p = 0.002). No significant difference was found for the cTnI levels ?0.6 ng/ml between non-survivors and survivors (p <0.05). Conclusion: Myocardial ischaemia and cell injury seem to be common in patients with septic shock and correlate with left ventricular dysfunction. Measurement of cTnI may be an easy and practical tool for monitoring cardiac damage in critically ill septic patients.Öğe CD7 positive acute myeloblastic leukemia exhibiting pleural and pericardial involvement as an initial manifestation(2001) Söker M.; Ayyildiz O.; Devecioglu C.; Haspolat K.A 12-year-old girl was admitted to our hospital because of cardiac tamponade and pleural effusion. Her pericardial and pleural fluid contained myeloblasts and a diagnosis of acute myeloblastic leukemia was made from the findings of a bone marrow smear. She was classified as M4 acute myeloblastic leukemia according to French-American-British classification. The surface marker analysis of the blasts was positive for CD7, CD33, CD14, CD34 and HLA-DR. Leukemic pericardial effusion with cardiac tamponade and pleural involvement is very rare as an initial manifestation of acute myeloblastic leukemia. We report a case with a diagnosis of CD7+ acute myeloblastic leukemia presenting initially with pericardial effusion complicated with cardiac tamponade and pleural involvement as an unusual presentation.Öğe The effect of growth hormone therapy on the serum calcium, phosphorus and alkaline phosphatase levels(1995) Narli N.; Haspolat K.; Kilinc M.; Gokten I.; Kirici G.; Kervancioglu M.In this study, the effect of growth hormone (GH) therapy on calcium (Ca), phosphorus (P) and alkaline phosphatase (ALP) serum levels in 23 patients with idiopathic GH deficiency were evaluated. Serum levels of Ca were not significantly different before and after GH therapy, but serum levels of P were significantly different at the end of the first and second years from the beginning of treatment. It was shown that the increase of chondrocytosis effects ALP levels significantly and in the second month of therapy the serum levels of ALP could reflect the biochemical result of therapy.Öğe The effect of thymosine 1 alpha and lamivudine combination therapy in chronic hepatitis B patients [1](2002) Dikici Bünyamin; Boşnak Mehmet; Haspolat K.[No abstract available]Öğe The evaluation of gastroesophageal reflux incidence in children with various symptoms by cintigraphy [3](1998) Yaramis A.; Gurkan F.; Haspolat K.; Dikici, Bünyamin; Derman O.; Soker M.; Yilmaz S.[No abstract available]Öğe Febrile seizures(1995) Kilinc M.; Narli N.; Bircan Z.; Haspolat K.In this review, childhood febrile seizures were evaluated and etiopathogenesis, clinical features, prognostic factors and the effect of rectal diazepam in prophylactic therapy were discussed.Öğe Henna induced acute hemolysis in a G6PD-Deficient patient: A case report(2000) Soker M.; Devecioglu C.; Haspolat K.; Dikicl B.; Dogru O.Lawsone is a chemical present in henna, the crushed leaves of which are used worldwide as a cosmetic agent to stain hair, skin and nails. Vitro observations showed that lawsone was capable of causing oxidative hemolysis in a close dependent manner in rats. In the literature, acute hemolysis after henna dye application over the human body is rare except in infancy. A Glucose-6-Phosphate Dehydrogenase (G6PD) enzyme deficient patient with acute hemolysis after exposure to henna is presented.Öğe Intravenous immunoglobulin in the treatment of Guillain-Barre syndrome(1997) Elevli M.; Yaramis A.; Soker M.; Haspolat K.; Gunbey S.[No abstract available]Öğe Parental history of migraine and bronchial asthma in children(2000) Gürkan F.; Ece A.; Haspolat K.; Dikici, BünyaminBackground: a possible association between migraine and various allergic disorders have been reported. It was aimed in this study to inquire the association between bronchial asthma in children and parental history of migraine. Methods and results: parental history of allergic diseases and migraine were inquired among 140 asthmatic children (91 males, 49 females) and 110 age and sex matched control subjects who had not any allergic or hypersensitivity disorders, followed-up at Pediatric outpatient clinics of Dicle University Hospital. While 13 of 140 asthmatic children (9.3%) had parental history of migraine, 2 of 110 control subjects (1.8%) had parental migraine history. Difference between asthmatic and control subjects was significant (OR: 5.5, 95% Cl: 1.3-25.0). Children who had parental history of migraine also had significantly more frequent parental history of asthma, eczema and particularly allergic rhinitis (p = 0.007). Conclusions: our results suggest that children are at increased risk of asthma if their parents have a history of migraine. Migraine in one generation and asthma in the next lead to the conclusion that the two disorders may have a relationship to a common denominator.Öğe Passive smoking and expired carbon monoxide concentrations in healthy and asthmatic children(2000) Ece A.; Gürkan F.; Haspolat K.; Derman O.; Kirbaş G.Background: Carbon monoxide (CO) in expired air has been reported to be an indirect measurement for the quantity of passive smoking. Since endogen CO is produced in inflammatory processes and inflammation is the main pathogenetic mechanism of asthma, it was aimed to investigate the relationship between the intensity of passive smoking and CO concentration in expired air of healthy and asthmatic children. Methods and Results: the study was performed in the outpatient pediatrics clinics and day care centers. Knowledge about indoor smoking habits were obtained from parents. The exhaled CO concentrations were measured by a portable device in 235 healthy (mean age, 4.4 ± 2.3 years) and 54 asthmatic (mean age, 4.5 ± 1.7 years) children. Children with no smoking parents had the lowest exhaled CO concentrations. Significant relationships were found between the number of smoking cigarettes in the house and exhaled CO concentrations in both healthy (p = 0.003) and asthmatic (p = 0.01) children. Carbon monoxide concentrations were higher in asthmatic children than healthy ones (mean ± SD, 1.32 ± 1.50 ppm and 0.86 ± 1.35 ppm, respectively, p = 0.028) if their parental smoking habits were not taken into account. Asthmatic children of nonsmoking parents had higher CO concentrations than healthy subjects of non-smoking parents (1.05 ± 1.55 ppm vs 0.37 ± 0.53 ppm, p = 0.01). On the other hand, asthmatic children who has no smoking parents and did not receive inhaled steroids had significantly higher CO concentrations (1.75 ± 1.45 ppm) than those who received steroids (0.58 ± 0.65 ppm, p = 0.024). Conclusions: exhaled CO can be used as an indicator of passive smoking in children. Higher expired CO of asthmatic children may reflect inflammation of the lung in asthma.Öğe Prevalence of asthma and other allergic disorders among schoolchildren in Diyarbakir, Turkey(2001) Ece A.; Ceylan A.; Saraçlar Y.; Saka G.; Gürkan F.; Haspolat K.This study was performed to describe the prevalence rates of allergic diseases among children in southeast Anatolia. A questionnaire survey of children six to 15 years old was conducted using a modified version of the Turkish translated ISAAC protocol, with additional questions concerning sociodemographic and environmental characteristics of children that could be potential risk factors for allergic disorders. Questionnaires were distributed to parents of all children aged below 11 years and to children themselves aged over 11 for completion. A total of 3,040 children returned the questionnaires. The lifetime prevalence rates of asthma, wheezing, allergic rhinitis and atopic dermatitis were 14.1%, 22.4%, 12.9%, and 7.8%, respectively. The prevalence of wheezing, rhinitis and chronic rash in the last 12 months were 14.7%, 39.9%, and 11.8%, respectively. The prevalence rates of symptoms and diagnoses of allergic disorders were similar in boys and girls. Passive smoking, pet ownership, number of household and socioeconomic status were not significant risk factors for allergic diseases. Family history of atopy was the most prominent risk factor for all types of allergic diseases. high prevalence rates of asthma, rhinitis and eczema exist among schoolchildren in southeast Anatolia.Öğe Tumors of the maxillofacial region in children: Retrospective analysis and long-term follow-up outcomes of 90 patients(2004) Tanrikulu R.; Erol B.; Haspolat K.The aim of this study was to carry out a retrospective analysis of maxillofacial Tumors in children and to present the lnog-term follow-up results. Our study was performed with a retrospective analysis of 90 patients under the age of 15 years with maxillofacial tumor treated in our clinic between 1985-2002. In addition, treatment modalities and long-term follow-up results of these patients were evaluated. According to our results, it was established that maxillofacial tumors were mostly observed in the 11-15 age group (39 cases, 43.3%) and on the mandible (48 cases, 53.3%). There were 21 (23.3%) odontogenic, 63 (70%) benign non-odontogenic and 6 (6.7%) malignant non-odontogenic. Mixed tumors were the most common type of the odontogenic tumors, and mesenchymal tumors were the most common non-odontogenic tumors. Surgical excision, curettage or en bloc resection were adequate for treatment of these tumors.
