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    Risk of Helicobacter pylori infection in newborn babies of Helicobacter pylori-positive pregnant women
    (1998) Dursun M.; Goral V.; Simsek H.; Yukselen V.; Hascelik G.; Canoru F.
    Helicobacter pylori (H.pylori) is one of the rare organisms that can maintain its life in acidic condition of stomach. A number of studies indicate that it is closely inked to mainly duodenal ulcer as well as peptic ulcer, non-ulcer dyspepsy, gastric cancer and MALT lymphoma. The aim of our study was to determine whether newborn infants of H.pylori-positive mothers are at risk of H.pylori infection A total of 48 mother and their newborn babies were included in the study. Soon after the birth, blood specimens were taken from both mothers and babies. Anti-H.pylori IgG was examined from the blood of the mothers by ELISA. The blood of babies of mothers with anti- H.pylori IgG-positive was investigated for both anti-H.pylori IgG and anti- H.pylori IgA. In 36 (75.0%) of 48 women included in the study, anti-H.pylori IgG antibody was found as positive. In addition, anti-H.pylori IgG was determined to be positive in 32 (89.0%) of 36 babies whose mothers were positive for anti-H.pylori IgG. These 32 babies whose anti-H.pylori IgG was positive were examined for anti-H.pylori IgA. In 3 babies (9.4%), it was found to be positive (p<0.01). In conclusion, owing to IgG's feature of being able to transmit through the placenta, it is clear that the presence of anti- H.pylori IgG in the serum of babies whose mothers are positive for anti- H.pylori IgG antibody cannot be an indicator of H.pylori infection. Determination of anti-H.pylori IgA antibody as positive is important and statistically significant (p<0.01). According to the results of this study, it can be said that at least the possibility of vertical transmission may exist.