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    Exploring 18 F-FDG uptake patterns in liver, spleen, and bone marrow: Implications for inflammatory and infectious conditions
    (Hellenic Soc Nuclear Medicine, 2024) Tuzcu, Sadiye Altun; Cetinkaya, Erdal; Guzel, Fatih; Cetin, lbey Erkin; Mete, Umit; Argin, Esref; Tasdemir, Bekir
    Objective: This study aimed to explore the relationship between fluorine-18-fluorodeoxyglucose (F-18-FDG) uptake in the liver, spleen, and bone marrow and inflammatory markers such as c-reactive protein (CRP), albumin, and erythrocyte sedimentation rate (ESR) in patients undergoing positron emission tomography/computed tomography (PET/CT) imaging for cancer diagnosis. Subjects and methods: This retrospective cross-sectional study included a total of 708 patients with a diagnosis of malignancy. Fluorine-18-FDG PET/CT images acquired between January 2021 and December 2022. Exclusion criteria comprised prior chemotherapy, radiotherapy, hematological malignancies, or liver/spleen tumors. Statistical analysis included correlation analysis, univariate, and multivariate regression analysis. Results: C-reactive protein levels demonstrated a significant positive correlation with F-18-FDG uptake in the spleen (r=0.104, P=0.006) and bone marrow (r=0.112, P=0.003). Albumin showed a negative correlation with liver F-18-FDG uptake (r=-0.220, P<0.001). Regression analysis revealed ESR's impact on spleen-to-liver (P=0.023) and bone marrow-to-liver (P=0.012) F-18-FDG uptake. Conclusion: This study demonstrates the association between inflammatory markers and F-18-FDG uptake in liver, spleen and bone marrow. C-reactive protein and ESR showing significant correlations with spleen and bone marrow F-18-FDG uptake, and albumin correlated with liver F-18-FDG uptake negatively. Erythrocyte sedimentation rate had significant impact on spleen and bone marrow F-18-FDG uptakes. These findings suggest the potential of F-18-FDG PET/CT in diagnosing inflammatory conditions, warranting further investigation into its clinical implications.
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    Local imaging to interpret tumor size in F18 fluorodeoxyglucose positron emission tomography/CT in lung cancers
    (Assoc Medica Brasileira, 2024) Tuzcu, Sadiye Altun; Kaplan, Ihsan; Ibiloglu, Ibrahim; Uyar, Ali; Guzel, Fatih; Guzel, Yunus; Tasdemir, Bekir
    OBJECTIVE: This study aimed to determine the thoracic and extra-thoracic extension of the disease in patients diagnosed with lung cancer and who had whole-body F18-fluorodeoxyglucose positron emission tomography/CT imaging and to investigate whether there is a relationship between tumor size and extrathoracic spread. METHODS: A total of 308 patients diagnosed with lung cancer were included in this study. These 308 patients were first classified as group 1 (SPN 30 mm>longest lesion diameter >= 10 mm) and group 2 (lung mass (longest lesion diameter >= 30 mm), and then the same patients were classified as group 3 (nodular diameter of <= 20 mm) and group 4 (nodular size of >20 mm). Group 1 was compared with group 2 in terms of extrathoracic metastases. Similarly, group 3 was compared with group 4 in terms of frequency of extrathoracic metastases. F18 fluorodeoxyglucose positron emission tomography/CT examination was used to detect liver, adrenal, bone, and supraclavicular lymph node metastasis, besides extrathoracic metastasis. RESULTS: Liver, bone, and extrathoracic metastasis in group 1 was statistically lower than in group 2 (p<0.001, p<0.01, and p=0.03, respectively). Liver, extrathoracic, adrenal, and bone metastasis in group 3 was statistically lower than that in group 4 (p<0.001, p=0.01, and p=0.04, p<0.01, respectively). The extrathoracic extension was observed in only one patient in group 3. In addition, liver, adrenal, and bone metastases were not observed in group 3 patients. CONCLUSION: Positron emission tomography/CT may be more appropriate for cases with a nodule diameter of <= 20 mm. Performing local imaging in patients with a nodule diameter of <= 20 mm could reduce radiation exposure and save radiopharmaceuticals used in positron emission tomography/CT imaging.