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Öğe Atypical clinical presentation of idiophatic thoracic spinal cord herniation(Lippincott Williams & Wilkins, 2008) Senturk, Senem; Guzel, Aslan; Guzel, EbruStudy Design. Case report. Objective. To report an adult female patient with idiopathic spinal cord herniation presenting with pain without symptoms of myelopathy. Summary of Background Data. Idiopathic spinal cord herniation is a rare but increasingly recognized cause of myelopathy that can be successfully diagnosed with the almost pathognomonic findings on magnetic resonance imaging. There are over 90 cases that were treated surgically reported in the literature. Methods. A 38-year-old woman presented with a 6-month history of chest pain radiating through to the back in bilateral T4 dermatome. Her neurologic examination was normal. Magnetic resonance study revealing ventral displacement and adherence of spinal cord at T4 level led to the diagnosis of idiopathic spinal cord herniation. Mild spinal cord atrophy with the dilatation of dorsal subarachnoid space was determined. Results. The patient is observed-up on conservative treatment for pain. Conclusion. Idiopathic spinal cord herniation is 1 of the causes of unexplained atypical thoracic pain with or without signs and symptoms of myelopathy. Magnetic resonance imaging is recommended to establish the diagnosis in patients, particularly age ranged from 36 to 59, whose clinical and laboratory findings are inconclusive.Öğe Bilateral symptomatic petrous apex effusion(Springer, 2010) Yildirim, Muzeyyen; Senturk, Senem; Guzel, Ebru; Guzel, Aslan; Topcu, IsmailPetrous apex effusions can present with aural fullness, hearing loss and dizziness. Although they can be followed-up when asymptomatic, clinical management of symptomatic patients is controversial. In this study, we present clinical and radiological findings of a 24-year-old patient with bilateral petrous apex effusion. She had been complaining of bilateral aural fullness and dizziness for 2 years. Radiological examinations revealed bilateral petrous apex effusion. After medical treatment, her symptoms gradually disappeared. In all previous published studies, unilateral petrous apex effusions were reported. To our best knowledge, this is the first patient with trapped fluid in bilateral petrous apex.Öğe Cervical Spinal Meningioma Mimicking Intramedullary Spinal Tumor(Lippincott Williams & Wilkins, 2009) Senturk, Senem; Guzel, Aslan; Guzel, Ebru; Bayrak, Aylin Hasanefendioglu; Sav, AydinStudy Design. Case report. Objective. To report a very unusual spinal meningioma, mimicking an intramedullary spinal tumor. Summary of Background Data. Spinal meningiomas, usually associated with signs and symptoms of cord or nerve root compression, are generally encountered in women aged over 40. Radiologic diagnosis is often established by their intradural extramedullary location on magnetic resonance images. Methods. A 60-year-old woman had a 6-month history of progressive weakness in her upper extremities, difficulty in walking, and cervical pain radiating through both arms. Neurologic examination revealed motor strength deficiency in all her extremities, with extensor reflexes, clonus, and bilateral hyper-reflexiveness. A sensory deficit was present all over her body. Magnetic resonance images revealed that the spinal cord appeared expanded with an ill-defined, homogeneously contrast-enhanced, lobulated, eccentric mass at the C1-C3 level. The patient was operated with a preliminary diagnosis of an intramedullary tumor. Results. At surgery, the mass was found to be extramedullary, and gross total resection was performed. Histopathological examination revealed a meningioma characterized by the presence of fibrous and meningothelial components. The patient was able to ambulate with a cane, and extremity strength and sensation improved 2 months after surgery. Conclusion. Spinal meningiomas can mimic intramedullary tumors, and should be considered in differential diagnosis of intradural tumors with atypical appearance.Öğe CT and MR imaging of chronic subdural haematomas: a comparative study(E M H Swiss Medical Publishers Ltd, 2010) Senturk, Senem; Guzel, Aslan; Bilici, Aslan; Takmaz, Ilker; Guzel, Ebru; Aluclu, M. Ufuk; Ceviz, AdnanQuestions under study/principles: This study was designed to compare CT and MR appearances of chronic subdural haematomas as well as CT- and MR-guided measurements of haematoma thicknesses. Methods: CT and MR images of 48 chronic subdural haematomas of 34 patients were reviewed retrospectively. The thickness measurements and imaging characteristics of haematomas were compared. Results: Levelling was observed in 25% of haematomas, and most of them (60%) had intra-haematomal membranes. All membranes could be delineated by MR imaging, whereas only 27% were defined by CT. Mixed density (52%) and T1 hyperintensity (59%) were commonly observed in membraned haematomas, but the difference was not statistically significant. Haematomas were measured significantly thicker on MR images. All patients had been treated with burr-hole craniotomy and irrigation. Conclusions: MR imaging is more sensitive than CT in determining the size and internal structures of chronic subdural haematomas.Öğe Factor X Deficiency Presenting with Bilateral Chronic Subdural Hematoma(Karger, 2010) Senturk, Senem; Guzel, Ebru; Bayrak, Aylin Hasanefendioglu; Bukte, Yasar; Guzel, AslanFactor X deficiency is a rare coagulation defect that can result in several hemorrhagic manifestations including central nervous system hematomas in infants and children. In this case report, we present computed tomography (CT) and magnetic resonance (MR) imaging findings of bilateral chronic subdural hematomas due to factor X deficiency. Cranial CT and MR imaging in a hypoactive 7-month-old male infant with right hemiparesis revealed bilateral chronic subdural hematomas at different stages. Laboratory findings showed a severe factor X deficiency, with a level of 0.7%. After fresh frozen plasma replacement, the patient was operated and the large hematoma on the left side evacuated. The patient recovered uneventfully and remained asymptomatic during the 1-year follow-up. Copyright (C) 2010 S. Karger AG, BaselÖğe Outcome of Primary Bone Fragment Replacement in Pediatric Patients with Depressed Skull Fracture(Karger, 2019) Oktay, Kadir; Guzel, Ebru; Unal, Emre; Yilmaz, Tevfik; Okten, Ali Ihsan; Guzel, AslanObjective: To evaluate pediatric patients who were operated with the diagnosis of depressed skull fracture. Methods: The records of pediatric patients who presented with traumatic head injury to multicenter neurosurgery clinics between 2002 and 2018 and who were operated with a diagnosis of depressed skull fracture were retrospectively reviewed. All of the patients underwent primary bone fragment replacement operation, and the patients' own bone flaps were used to repair depressed skull fractures in all of them. Results: A total of 78 patients were included in the study. Of the study group, 20 patients presented with mild head injury, 37 had moderate head injury, and 21 had severe head injury. Dural injury was present in 67 patients (86%) and the dura was intact in 11 patients (14%). After surgery, 63 patients (81%) had good outcome, 8 patients (10%) had moderate disability, and 5 patients (6.5%) had severe disability. Two patients with multiple accompanying cranial pathologies died and the mortality rate was 2.5%. Infection was detected in only 2 of the 78 patients who were treated within the first 72 h after trauma. One of them had meningitis and the other skin infection. Both patients were treated with appropriate antibiotherapy. None of the patients in the study group had an infection involving the bone, such as osteomyelitis, or the tissues under the bone, such as subdural-epidural empyema or abscess. None of the patients required reoperation and removal of the bone. Conclusion: In the present study, as the pathologies accompanying the depressed skull fractures of the patients increased, Glasgow Coma Scale scores at arrival and Glasgow Outcome Scale scores at discharge decreased. Regardless of whether the depressed fracture is simple or compound, primary bone fragment replacement with appropriate decontamination of the fractured bone and operation area via single-session intervention gives good results. It is important to perform the surgery as soon as possible to reduce the risk of contamination. Primary bone fragment replacement seems to be an appropriate treatment option for depressed skull fractures. (c) 2019 S. Karger AG, BaselÖğe Pituitary Carcinoma Presenting With Multiple Metastases: Case Report(Sage Publications Inc, 2008) Guzel, Aslan; Tatli, Mehmet; Senturk, Senem; Guzel, Ebru; Cayli, Suleyman Rustu; Sav, AydinPituitary carcinoma, an uncommon tumor in adults, generally presents with craniospinal and systemic metastases. We report a case of pituitary carcinoma with multiple craniospinal metastases in a child. A 9-year-old girl, who had had a ventriculoperitoneal shunt operation 3 years ago, presented with complaints of progressive visual disturbance, headache, speech difficulty, and gait disturbance for the past 2 months. Neurological examination revealed papilledema, visual loss, and dysarthria. Cranial magnetic resonance imaging revealed a large contrast-enhanced tumor in the left frontal region together with multiple lesions in the sellar-parasellar region and posterior fossa. Multiple intraspinal contrast-enhanced metastatic lesions were also seen. Histopathological and immunohistochemical examination of the excised left frontal mass revealed pituitary carcinoma. Treatment with cyclic temozolomide was started after the operation, but the patient died after 2 months Without response to medical therapy. This is the first pediatric case, to the authors' knowledge, Of a pituitary carcinoma with widespread intracranial and intraspinal metastases.Öğe Solitary eosinophilic granuloma of the parietal bone in an adult patient(Riyadh Armed Forces Hospital, 2007) Tatli, Mehmet; Guzel, Aslan; Guzel, EbruEosinophilic granuloma (EG) is a well-recognized benign form of Langerhans-cell histiocytosis. The estimated incidence of EG is 3-4 per million of the population. More patients are children and adolescents between the ages of 1-15 years. In this report, we present an adult patient. A 37-year-old male was admitted with headache and right parietal swelling that was present for 2 months together with epileptic attacks. Cranial CT scan revealed a right parietal osteolytic lesion with large epidural and subcutaneous mass, causing brain compression. Total removal of the mass was carried out with cranioplasty. Histopathological examination disclosed Langerhans' cell histiocytosis and immunohistochemical detection of S-100 antigen. At follow-up, he had no neurological deficits, and control CT was normal. For symptomatic solitary calvarial EG, surgical excision is the main treatment option. Surgical treatment is simple, quick, and allows histological diagnosis of the osteolytic lesions.