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Öğe Amniotic fluid amino acid levels in non-immune hydrops fetalis: a case-control study(Assoc Bras Divulg Cientifica, 2011) Erdemoglu, M.; Kuyumcuoglu, U.; Guzel, A. I.; Celik, Y.; Kale, E.In a prospective case-control study, we compared the amniotic fluid amino acid levels in non-immune hydrops fetalis (NIHF) and normal fetuses. Eighty fetuses underwent amniocentesis for different reasons at the prenatal diagnosis unit of the Department of Obstetrics and Gynecology, Faculty of Medicine, Dicle University. Forty of these fetuses were diagnosed with NIHF. The study included 40 women each in the NIHF (mean age: 27.69 +/- 4.56 years) and control (27.52 +/- 5.49 years) groups, who had abnormal double-or triple-screening test values with normal fetuses with gestational ages of 23.26 +/- 1.98 and 23.68 +/- 1.49 weeks at the time of sample collection, respectively. Amniotic fluid amino acid concentrations (intra-assay variation: 2.26-7.85%; interassay variation: 3.45-8.22%) were measured using EZ: faast kits (EZ: faast GC/FID free (physiological) amino acid kit; Phenomenex, USA) by gas chromatography. The standard for quantitation was a mixture of free amino acids from Phenomenex. The levels of 21 amino acids were measured. The mean phosphoserine and serine levels were significantly lower in the NIHF group, while the taurine, a-aminoadipic acid (aaa), glycine, cysteine, NH(4), and arginine (Arg) levels were significantly higher compared to control. Significant risk variables for the NIHF group and odds coefficients were obtained using a binary logistic regression method. The respective odds ratios and 95% confidence intervals for the risk variables phosphoserine, taurine, aaa, Arg, and NH(4) were 3.31 (1.84-5.97), 2.45 (1.56-3.86), 1.78 (1.18-2.68), 2.18 (1.56-3.04), and 2.41 (1.66-3.49), respectively. The significant difference between NIHF and control fetuses suggests that the amniotic fluid levels of some amino acids may be useful for the diagnosis of NIHF.Öğe The association of preoperative thrombocytosis with prognostic factors in malign ovarian tumor(I R O G Canada, Inc, 2010) Kuyumcuoglu, U.; Guzel, A. I.; Celik, Y.; Erdemoglu, M.Purpose We assessed the association of preoperative thrombocytosis with prognostic factors in malign ovarian tumor Methods Over a five-year period, cases treated for ovarian cancer were randomly assigned The data were collected from gynecological oncology. radiation oncology, medical oncology and pathology departments Statistical analyses were carried out by using the statistical packages for SPSS 12 0 for Windows (Chicago, IL. USA) Survival was analyzed by the method of Kaplan and Meier. using log-rank (Mantel-Cox) analysis Results 51 cases with ovarian cancer were evaluated Cases with thrombocytosis were found to have greater CA-125 levels, more advanced stage disease, more ascites and shorter periods of survival Conclusion Thrombocytosis is a poor prognostic factor in ovarian cancer As reported previously, it is associated with aggressive tumor biology Thus, preoperative thrombocytosis can be a used as a marker of poor outcomesÖğe The clinical significance of HPV screening in premalignant cervical lesions(7847050 Canada Inc, 2010) Kuyumcuoglu, U.; Hocaoglu, S.; Guzel, A. I.; Celik, Y.Purpose We evaluated the clinical significance of human papilloma virus (HPV) screening in premalignant cervical lesions Methods This prospective study was performed at Dicle University, School of Medicine, Department of Obstetrics and Gynecology. from January 2009 to June 2009 A total of 60 cases were evaluated Thirty cases had premalignant cervical lesions The prevalence of HPV was analyzed by polymerase chain reaction and types determined by Hybrid Capture II The cases that had premalignant cervical lesions were evaluated with colposcopy Statistical analyses were carried out by using the statistical packages for SPSS version 12 0 for Windows (Chicago. IL, USA) Results Of all the cases. those with premalignant cervical lesions had higher prevalence of HPV DNA The cases that had high oncogenic HPV type had more abnormal colposcopic findings Conclusion Premalignant cervical lesions should be evaluated by cervical cytology. colposcopy, HPV DNA screening and cervical tissue sampling In this way, development of cervical cancer can be preventedÖğe Clinical significance of procalcitonin in cervico-vaginal secretions of women with preterm rupture of membranes(I R O G Canada, Inc, 2010) Kuyumcuoglu, U.; Kangal, K.; Guzel, A. I.; Celik, Y.Purpose: To compare vaginal fluid procalcitonin (PCT) concentrations in cases of preterm premature rupture of membranes (PPROM) and healthy pregnant women, and to determine whether the PCT concentrations are of value in the diagnosis of PPROM cases and clinical amnionitis. Methods: 50 cases with PPROM and 50 healthy pregnant women were enrolled in the study. In the PPROM group, analysis was conducted on PCT concentrations with reference to serum leucocytosis, serum C-reactive protein level and urine analysis, as well as to presence/absence of clinical amnionitis. Statistical analyses were carried out by using the statistical packages for SPSS 12.0 for Windows (SPSS Inc., Chicago, IL, USA). Results: Procalcitonin levels in the PPROM group were significantly higher than in cases of healthy pregnant women (1.17 vs 0.05 ng/ml; p < 0.001). In the PPROM group PCT concentrations between the patients with and without clinical amnionitis were comparable. Also, a significant correlation was observed between PCT and leucocytosis (r = 0.64; p < 0.001) and C-reactive protein (r = 0.90; p < 0.001). Conclusion: These findings suggest that the value of vaginal fluid PCT determinations can be useful for diagnostics of PPROM cases suspected of intrauterine infection.Öğe The Effect of Flurbiprofen as Prophylactic Analgesic before Hysterosalpingography(Sage Publications Ltd, 2010) Guzel, A. I.; Kuyumcuoglu, U.; Erdemoglu, M.Hysterosalpingography (HSG) is associated with pain during the four-step procedure. This prospective, double-blind, randomized, placebo-controlled study was conducted to investigate the effect of the analgesic flurbiprofen, administered prior to HSG, in 60 women. Thirty women were randomized to receive 100 mg of flurbiprofen, orally, 1 h prior to HSG and a further 30 women were randomized to receive placebo. Injection of contrast medium was more painful than the other steps in the HSG procedure in both groups; however, there was no significant between-group difference in terms of pain experienced in the individual steps of HSG. Pain scores at 5 and 30 min after the procedure were compared between the two groups. There was a significant decrease in the visual analogue scale pain score in the flurbiprofen-treated group compared with the placebo-treated group at both time points. Thus, the authors recommend flurbiprofen as a prophylactic analgesic to be administered before HSG procedures.Öğe Evaluation of adolescent pregnancies: 10-year experience of a hospital in rural Turkey(I R O G Canada, Inc, 2011) Demir, B.; Guzel, A. I.; Celik, Y.; Demir, S.; Demir, F.Purpose: To evaluate the characteristics of adolescent pregnancies admitted to our clinic. Materials and Methods: This retrospective and descriptive study was performed at Ergani State Hospital from January 2000 to December 2010. This is an outpatient gynecology and obstetrics at government hospital in Southern Eastern Region of Turkey. A total of 15,210 pregnancies were delivered during the study period, of whom 711 of them were adolescent pregnancies. Statistical analyses were carried out using the statistical packages for SPSS 15.0 for Windows (SPSS Inc., Chicago, IL, USA). Results: During the study period, of the total of 15,210 deliveries 711(4.6%) were adolescent pregnancies (age range 14-19 years). The mean age (95% CI) of the patients was 17.90 +/- 1.12 (17.82-17.98) years old. Most of the patients were nulliparous (n = 559, 78.60%). Mean gestational weeks, fetal birth weight and fetal birth length and 95% Cl values were as follows: 37.11 +/- 2.53 (36.93-37.30), 3045.73 +/- 51.70 (3007.65-3083.79) and 48.68 +/- 2.31 (48.51-48.85), respectively. Six hundred and twenty (87.20%) of the patients delivered spontaneously by the vaginal route, while 91 (12.80%) were delivered by cesarean section. Although the age range of the patients was not wide, there was a significant correlation between maternal age, gestational age, fetal birth weight and fetal birth length (p < .01). Conclusion: According to this study, the ratio of adolescent pregnancies was found to be 4.6% which was lower than other regions of Turkey. The majority of the patients were nulliparous and most delivered spontaneously by the vaginal route. There was a significant correlation between maternal age, gestational age, fetal birth weight and fetal birth length.Öğe Outcomes of pregnancies in women with parity ten or more: a case control study(I R O G Canada, Inc, 2012) Demir, B.; Guzel, A. I.; Demir, S.; Demir, F.; Celik, Y.Purpose: To determine the outcomes of pregnancies in women with parity ten and more. Materials and Methods: We designed this study in a government hospital in rural Turkey. Pregnant women with parity of ten or more (n = 126) were evaluated and compared with pregnant women with parity lower than ten (n = 90). The risk factors recorded were maternal age, parity, gestational age (weeks), delivery mode, fetal birth weight and Apgar scores. Statistical analyses were carried out using the statistical packages for SPSS 15.0 for Windows (SPSS Inc., Chicago, IL, USA). Results: During the study period, a total of 12,551 deliveries were delivered at the current clinic. One hundred and twenty-six mothers were delivered with parity ten or more with a ratio of 1.01%. There was a statistically significant difference between the study and control group by means of maternal age, parity, fetal birth weight and 1- and 5-min Apgar scores (p < 0.05). There was no difference in delivery mode between the groups. Conclusion: According to this study, pregnant women with parity ten or more showed no adverse clinical characteristics when compared with pregnant women with parity lower than ten.Öğe Umbilical cord prolapse in the southeast region of Turkey: evaluation of 79 cases(I R O G Canada, Inc, 2010) Erdemoglu, M.; Kale, A.; Kuyumcuoglu, U.; Akdeniz, N.; Guzel, A. I.Objective: The aim of the study was to determine the risk factors and perinatal outcomes of umbilical cord prolapse (UCP). Material and Methods: This study was performed at Dicle University between January 2000 and December 2008 on 79 cases in which deliveries were complicated by umbilical cord prolapse. Results: 0.36% of all deliveries were complicated by umbilical cord prolapse. The presentation of the fetuses were as follows: vertex, breech and transverse lie and foot presentation. Thirty-four (43%) fetuses with UCP had a fetal weight of <= 2500 g as compared with nine (9%) for fetuses in the control group (p < 0.05). Mothers in the study group were 1.3 times more likely to be multiparas than the control group (p = 0.16) Cesarean section was performed in 76 cases (96.2%) and there were nine (11.3%) perinatal deaths. Conclusion: Umbilical cord prolapse is a risk factor of perinatal morbidity and mortality. Fetal weight <= 2500 and abnormal fetal presentation are associated with increased risk of umbilical cord prolapse. Cesarean section resulted in a significantly decreased risk of perinatal mortality.
