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    Evaluation of maternal and fetal outcomes in pregnant women with gestational thrombocytopenia
    (Bayrakol Medical Publisher, 2024) Sunar, Nebahat; Sizer, Mulaim; Gunsel, Hamdin; Tekes, Guelten Cirkin; Donmez, Dicle Akkilic; Icen, Mehmet Sait
    Aim: Investigate the relationship between gestational thrombocytopenia (GT) and adverse maternal and fetal outcomes in pregnant women. Material and Methods: 97 patients who were diagnosed with gestational thrombocytopenia during pregnancy, had no other disease that causes thrombocytopenia and delivered in our clinic were included in the study. The patients were divided into two groups according to their platelet values. Group-1 platelet count was <70.000/mm3 and Group-2 platelet count was 70.000- 150.000/mm3. In the analysis of negative perinatal outcomes, logistic regression analysis was performed. P <0.05 was considered significant in the analysis results. Results: From the laboratory data of the patients diagnosed with gestational thrombocytopenia, the mean platelet count was 85.28 +/- 27.08 (min -max: 22-142) and mean hematocrit was 35.91 +/- 3.63 (min -max: 21-45). When the groups were evaluated considering their hematocrit values; the mean hematocrit value of the patients in Group-2 (36.42 +/- 3.22) was higher than the mean hematocrit value (34.26 +/- 4.39) of the patients in Group-1, and a significant difference was found between them (p:0.03). This significant difference was also present when the platelet value was taken as the limit of 110,000 (p:0.039). Discussion: Apgar scores are lower in patients diagnosed with gestational thrombocytopenia and with platelet values below 70,000, and the need for blood transfusion (erythrocyte suspension, FFP (Fresh Frozen Plasma) and platelet product) is higher. The need for erythrocyte transfusion continues even when the platelet limit is 80,000, and the need for platelet transfusion is 100,000.
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    The role of hemogram parameters in predicting the severity of preeclampsia
    (Bayrakol Medical Publisher, 2024) Sizer, Mulaim; Peker, Nurullah; Gunduz, Reyhan; Evsen, Mehmet Siddik; Sunar, Nebahat; Gunsel, Hamdin
    Aim: The purpose of this study was to examine the significance of hemogram parameters in predicting preeclampsia and/or preeclampsia severity in patients with pre -diagnosis of preeclampsia. Material and Methods: The study was retrospective and comprised 198 patients with preeclampsia, 158 with severe preeclampsia and 40 with non -severe preeclampsia, as well as 126 pregnant women who had a healthy pregnancy as the control group. From the hemogram parameters, platelet count (PLT), neutrophil count, mean platelet volume (MPV), mean erythrocyte volume (MCV), leukocyte count and neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (TLR) and platelet/neutrophil ratio (TNR) were calculated. The pregnant women included in the study were compared in terms of these parameters. Results: While there was no statistically significant difference between the groups in the statistical analysis of MCV, MPV, NLR, and TNO, which are the parameters studied in PE groups with and without severe features, a statistically significant difference was found in these parameters between the control group and the preeclampsia group. At the TNO 35,1250 cut-off value, the sensitivity was 83.8 %, the specificity was 41.3 %, the positive predictive value was 69.17 %, and the negative predictive value was 61.90 %, and it was found that this value predicted the presence of PE as 69%. Discussion: In this study, we discovered that MPV, MCV, TNO, and NLO levels differed significantly between the PE and control groups. However, the sensitivity and specificity rates of these parametria in the detection of preeclampsia are far below significant values.