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Öğe Biomechanical Evaluation of Implant Osseointegration After Guided Bone Regeneration With Different Bone Grafts(Lippincott Williams & Wilkins, 2021) Gunes, Nedim; Gul, Mehmet; Dundar, Serkan; Tekin, Samet; Bozoglan, Alihan; Ozcan, Erhan Cahit; Karasu, NecmettinThe aim of this study was to compare the biomechanical osseointegration of titanium implants after guided bone regeneration (GBR) with a hydroxyapatite graft, deproteinized bovine bone graft, human-derived allograft, and calcium sulfate bone graft. Thirty-two female Sprague Dawley rats were divided into four groups, each containing eight (n = 8) rats: hydroxyapatide (HA), deproteinized bovine bone graft (DPBB), allograft (ALG), and calcium sulfate. Bone defects were created in the tibia of the rats, which were grafted with HA, DPBB, ALG, or CP bone grafts for the purpose of GBR. Ninety days after surgery, machine-surfaced titanium implants were inserted into the area where GBR had been undertaken. After 90 days of the surgical insertion of the implants, the rats were sacrificed, the implants with surrounding bone tissue were removed, and biomechanical osseointegration (N/cm) analysis was performed. No statistically significant differences were found among the groups in osseointegration (N/cm) three months after the GBR procedures (P > 0.05). According to the biomechanical results, none of the grafts used in this study was distinctly superior to any of the others.Öğe A comparative investigation of the effects of Resveratrol and dental pulp delivered mesenchimal stem cells on rat tibia bone defect healing(Univ Zulia, Facultad Ciencias Veterinarias, 2024) Agin, Hatice Demircan; Gunes, Nedim; Guler, RidvanResveratrol (3,4,5-trihydroxystilbene), an antioxidant compound, has a natural phytoalexin structure and also has many properties such as anti-inflammatory, antineoplastic and antiplatelet. In addition, mesenchymal stem cells isolated from various tissues are considered as a potential cell source for bone regenerative therapies. The present study aims to examine the effects of Resveratrol and dental pulp- derived mesenchymal stem cells on new bone formation in rats, both isolated and combined, by immunohistochemical methods. Twenty eigth Spraque Dawley male rats were used in the study. The rats were divided into four groups with seven rats in each group; the control group (Group 1) (n=7), the Systemic Resveratrol group (Group 2) (n=7), the Stem cell group (Group 3) (n=7), the Stem cell + Systemic Resveratrol group (Group 4) (n=7). A defect was opened on the tibia bones of the rats in all groups with a trephane bur (diameter of 3 mm and a length of 4 mm). After the 4-week experiment, all rats were sacrificed following the experimental protocols specific to each group. The specimens of tibia were subjected to histomorphological examination in fixative solutions. Values of inflammation, connective tissue formation, osteoclastic activity, osteoblast values, new bone formation, BMP2 and BMP4 expression levels obtained for all groups were evaluated by statistical analysis. Compared to the control group, new bone formation and osteoblastic activity were found to be significantly higher in the Stem cell group and Stem cell + Systemic Resveratrol group. ( P =0.001) Additionally, new bone formation in the Systemic Resveratrol group was found to be significantly lower than in the Stem cell + Systemic Resveratrol group. ( P =0.006) No significant difference was observed between other groups. ( P >0.05) According to the results of the study, it was observed that Stem cell + Resveratrol treatment was more effective than isolated Resveratrol or isolated stem cell treatment applications, it induced the development of more bone trabeculae, decrease inflammation and increased the number of osteoblasts involved in bone formation. In the light of these data, it was concluded that the combined use of Resveratrol and Stem cells is more effective on the healing of bone defects than their isolated use.Öğe Comparison of the effects of different loading locations on stresses transferred to straight and angled implant-supported zirconia frameworks: a finite element method study(Taylor & Francis Ltd, 2015) Guven, Sedat; Atalay, Yusuf; Asutay, Fatih; Ucan, Musa Can; Dundar, Serkan; Karaman, Tahir; Gunes, NedimThe paper presents three-dimensional (3D) finite element models of straight and angled implants and their zirconium-based superstructures. The key objective was to compare the influence of different loading conditions on the stress distribution of straight and angled implants and the zirconia frameworks. 3D finite element straight- and angled-implant models of a mandibular section of bone with missing second molars and their zirconium-based superstructures were used. The straight and angled implants were 4.7 x 13-mm screw-type dental implant systems. Total loads of 300 N were applied in a vertical direction and in an oblique (30 degrees to the vertical) direction buccolingually. Maximum and minimum von Mises stress values of the titanium structures (abutment and implant body) and zirconia frameworks were calculated. When the two groups were examined, the highest stress value was in the zirconia framework of the angled implant-supported model with an oblique loading force (731.46 MPa). The lowest stress values were concentrated in the straight implant-supported model. Thus, the stress values in the angled implant-supported crown were higher than those in the straight implant-supported model. Stress values with oblique loading forces were higher than the values with vertical loading forces. The highest stress value in the zirconia framework was similar to the ultimate strength of the zirconia.Öğe A comparison of the effects of methylprednisolone and tenoxicam on pain, edema, and trismus after impacted lower third molar extraction(Int Scientific Information, Inc, 2014) Ilhan, Ozgur; Agacayak, Kamil Serkan; Gulsun, Belgin; Koparal, Mahmut; Gunes, NedimBackground: The aim of the present study was to compare the effects of preemptive intravenous tenoxicam and methylprednisolone administrations on extraction of impacted third molars. Material/Methods: This was a placebo-controlled, randomized, double-blind, clinical trial. A total of 60 adult patients ages 18-40 years with the complaints of impacted third molar teeth were included in the study. Results: The postoperative swelling ratios (p < 0.05) and pain scores (p < 0.05) were significantly better in both study groups than in the control group and there was no statistically significant difference between methylprednisolone and tenoxicam groups with regards to the edema and pain relief. Conclusions: Preoperative administration of 80 mg methylprednisolone achieves better control of trismus than tenoxicam without any significant differences in edema and pain control in impacted third molar teeth extraction.Öğe Effects of Systemic Propranolol Application on the New Bone Formation in Periimplant Guided Bone Regeneration(Uab Stilus Optimus, 2021) Gunes, Nedim; Gul, Mehmet; Dundar, Serkan; Artas, Gokhan; Kobat, Mehmet Ali; Tekin, Samet; Bozoglan, AlihanObjectives: The aim of this experimental animal study was to evaluate the effects of systemic propranolol on new bone formation in peri-implant bone defects. Material and Methods: Implant slots were created 4 mm long and 2.5 mm wide. After the titanium implants were placed in the sockets, 2 mm defects were created in the neck of the implants. Bone grafts were placed in these defects. Then the rats were randomly divided into three equal groups: control (n = 8), propranolol dose-1 (PRP-1) (n = 8), and propranolol dose-2 (PRP-2) (n = 8) groups. In the control group, the rats received no further treatment during the eight-week experimental period after the surgery. The rats in the PRP-1 and PRP-2 groups were given 5 mg/kg and 10 mg/kg propranolol, respectively, every three days for the eight-week experimental period after the surgery. At the end of the experimental period, the rats were euthanized. Blood serum was collected for biochemical analysis, and the implants and surrounding bone tissues were used for the histological analysis. Results: There were no significant differences in the histological analysis results and the biochemical parameters (alkaline phosphatase, calcium, creatinine and phosphorus) of the groups (P > 0.05). Also, in the test groups, there was numerically but not statistically more new bone formation detected compared with the controls. Conclusions: Within the limitations of this study, propranolol did not affect the new bone formation in peri-implant defects.Öğe Evaluation of Mandibular Fractures in Children during Five years' in a Dental School(Drunpp-Sarajevo, 2012) Yaman, Ferhan; Atilgan, Serhat; Erol, Behcet; Ucan, Musa Can; Yilmaz, Utku Nezih; Agacayak, Serkan Kamil; Gunes, NedimMandibular fractures are rarely encountered among the pediatric population, and when they do present, their clinical features differ from those in adults. This retrospective study looked at the age, sex, type and cause of fracture, treatment method and associated injuries and complications in 260 cases of mandibular fracture in children under age 16. Among the most significant findings: Fracture incidence had a 3:5 male:female ratio; 52% of all mandibular fractures involved condyle/subcondyle fractures and 50.7% involved symphysis/parasymphysis fractures; the most common treatment method was intermaxillary fixation; in no cases were severe complications observed during the healing period.Öğe Investigation of the Effects of Ozon and Propolis on the Healing of Bone Defects: An Experimental Study(Lippincott Williams and Wilkins, 2024) Durmuş, Halil İbrahim; Gunes, NedimBACKGROUND /aim: This study explores the effects of ozone and propolis on the healing of critically sized bone defects at both the histologic and molecular levels, and the locations and concentrations of osteopontin and osteonectin during healing; both proteins play roles during bone healing. Materials and methods: This study used 56 adult male Sprague-Dawley rats of an average weight of 350 g, divided into four groups of 14: a control group, a topical ozone group (O), a topical ozone + systemic propolis (O + PO) group, and a systemic propolis group (PO). Seven rats from each group were sacrificed at the end of week 4 and the other seven at the end of week 6. Tissues were subjected to histologic and immunohistochemical examinations in a fixative solution. The results were analyzed using the statistical software package SPSS 23 (Statistical Package for the Social Sciences - IBM). Results were considered significant at the 95% confidence level (P<0.05). Results: Graft sections were immunostained for osteonectin. Staining was low in the control group but moderate in the other three groups; the differences were significant. The three experimental groups did not differ significantly. Graft sections were also immunostained for osteonectin. At 4 weeks, staining was low in the control group but moderate in the other 3 groups. At 6 weeks, stronger staining was apparent in the 3 experimental groups. At both 4 and 6 weeks, the differences between the control and experimental groups were significantly different, but the differences among the experimental groups were not. Conclusion: The authors' results are compatible with the literature. Ozone and propolis, given separately or together, improved bone healing, increased bone formation, and reduced bone destruction. However, further research is required. Copyright © 2024 by Mutaz B. Habal, MD.Öğe Long-term effects of antihypertensive medications on bone mineral density in men older than 55 years(Dove Medical Press Ltd, 2014) Agacayak, Kamil Serkan; Guven, Sedat; Koparal, Mahmut; Gunes, Nedim; Atalay, Yusuf; Atilgan, SerhatIntroduction: In this study, we investigated the effects of long-term antihypertensive treatment with calcium channel blockers or beta blockers on the bone mineral density of maxilla, as determined by cone-beam computed tomography (CBCT). Material and methods: This retrospective study was conducted on CBCT images of men older than 55 years who had received different dental indications. Data were grouped into three categories according to the antihypertensive medication history of the patients: group A included patients who had been taking beta-blocker treatment for more than 5 years, group B included patients who had been taking calcium channel blocker treatment for more than 5 years, and the control group included patients who had never used any hypertensive medications before. Results: Statistically significant differences were observed between the beta blocker and calcium channel blocker groups. Conclusion: In hypertension treatment, beta blockers may be preferred to calcium channel blockers in patients at high risk for osteoporosis and bone resorption. Keywords: bone mineral density, CBCT, beta blockers, calcium channelÖğe Pentoxifylline and electromagnetic field improved bone fracture healing in rats(Dove Medical Press Ltd, 2015) Atalay, Yusuf; Gunes, Nedim; Guner, Mehmet Dervis; Akpolat, Veysi; Celik, Mustafa Salih; Guner, RezzanBackground: The aim of this study was to evaluate the effects of a phosphodiesterase inhibitor pentoxifylline (PTX), electromagnetic fields (EMFs), and a mixture of both materials on bone fracture healing in a rat model. Materials and methods: Eighty male Wistar rats were randomly divided into four groups: Group A, femur fracture model with no treatment; Group B, femur fracture model treated with PTX 50 mg/kg/day intraperitoneal injection; Group C, femur fracture model treated with EMF 1.5 +/- 0.2 Mt/50 Hz/6 hours/day; and Group D, femur fracture model treated with PTX 50 mg/kg/day intraperitoneal injection and EMF 1.5 +/- 0.2 Mt/50 Hz/6 hours/day. Results: Bone fracture healing was significantly better in Group B and Group C compared to Group A (P<0.05), but Group D did not show better bone fracture healing than Group A (P>0.05). Conclusion: It can be concluded that both a specific EMF and PTX had a positive effect on bone fracture healing but when used in combination, may not be beneficial.Öğe Systemic and local zoledronic acid treatment with hydroxyapatite bone graft: A histological and histomorphometric experimental study(Spandidos Publ Ltd, 2016) Gunes, Nedim; Dundar, Serkan; Saybak, Arif; Artas, Gokhan; Acikan, Izzet; Ozercan, I. Hanifi; Atilgan, SerhatIn this study, the aim was to compare the relative efficacy of systemic and local zoledronic acid (ZA) on a hydroxyapatite (HA) bone graft in a rat critical-size calvarial bone defect. In total, 84 female rats were divided into four groups: Empty control (EC) group with no treatment applied; HA group, in which only HA bone graft material was used in the calvarium; and HA plus local ZA (HA+LZA) and HA plus systemic ZA (HA+SZA) groups, in which animals received ZA locally or systemically, respectively, with HA bone graft material in the calvarium. A 5-mm standardised critical-size calvarial bone defect was created with a standard trephine drill and the respective treatment was applied. Rats were sacrificed 7, 14 and 28 days later. The numbers of osteoclasts and osteoblasts, and degree of bone formation were evaluated histopathologically and histomorphometrically. Statistically significant differences were detected between the HA, HA+LZA and HA+SZA groups and the EC group for new bone formation (P<0.05). Osteoblast numbers in the HA+LZA and HA+SZA groups were significantly higher compared with those in the EC and HA groups (P<0.05). No statistically significant difference was detected between the HA+LZA and HA+SZA groups in new bone formation or osteoblast number (P>0.05). Bone formation was significantly higher in the HA group than in the EC group (P<0.05). The numbers of osteoclasts in the HA+LZA and HA+SZA groups were significantly higher than those in the groups EC and HA (P<0.05); however, there was no significant difference between groups HA+LZA and HA+SZA (P>0.05). Within the limitations of this study, systemic or local administration of ZA enhanced new bone formation with a HA bone graft in a rat critical-size calvarial defect model.
