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    Phosphodiesterase-5 inhibitors may facilitate bone defect recovery
    (Verduci Publisher, 2011) Yaman, F.; Atilgan, S.; Gunes, N.; Agacayak, S.; Gunay, A.; Ucan, M. C.; Bakir, S.
    Background and Objectives: Bone healing is still one of the most important problems of the oral and maxillofacial surgery procedures. This study was designed to evaluate the effect of sildenafil citrate (which is used for erectile dysfunction) on bone defect healing in an experimental animal model. Materials and Methods: A total of 42 male Wistar-albino rats were randomly assigned to the control group (n=21) or the study group (n=21). The control group was fed on a standard laboratory diet until 12 h before surgery, whereas the study group received Sildenafil citrate via orogastric tube 10 mg/kg once a day for 30 days. Under anaesthesia, a 3x3x2 mm depth defect was made on tibia of each rat. 7 animals from each group were euthanised on postoperative days 7,15 and 30. Bone samples were taken for examination, histologically on day 7, by 3D dental tomography on day 15, and for bone strength resistance on day 30. Results: Statistically significant differences were determined between the groups from the inflammatory and repair phase, with the healing process being more advanced in the Sildenafil group. Conclusions: Sildenafil citrate can be used as a supporting factor to accelerate the healing process of bone. In future comprehensive studies will need to demonstrate the Sildenafil citrate affect on bone defect healing.
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    A THREE DIMENSIONAL ANALYSIS OF RECONSTRUCTION PLATES USED IN DIFFERENT MANDIBULAR DEFECTS
    (Taylor & Francis Ltd, 2010) Atilgan, S.; Erol, B.; Yardimeden, A.; Yaman, F.; Ucan, M. C.; Gunes, N.; Atalay, Y.
    In this study, the reasons of breaking of the reconstruction plates used in mandibular continuity or mandibular defects were investigated. The study was conducted on 3 cases in which reconstruction plates were used for tumor resection or invasive wound. The objective was to evaluate the mechanical stress in reconstruction plates by means of the finite element method. Three dimensional model of reconstruction plate was exposed to chewing force. A commercial finite element solver (ANSYS) was then applied to this plate to compute the stresses generated in chewing situation. Stress analyses have been carried out by applying Von Mises Yielding Criteria. In the standard reconstruction plate, the results of the finite element analysis revealed that stress resulting from the simulated functional loadings which far exceeded the strengths of the components. The main application of this study was the prediction of fractures as a consequence of known forces. If it was assumed that the patient executes several thousand masticatory movements within a week, a dynamic strain would be present due to the large number of changes in loading, so that there was a danger of a fatigue fracture at the point of the stress concentration (as seen in the analysis), as is also confirmed by clinical practice.