Yazar "Gulhan, Mehmet Fuat" seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • [ X ]
    Öğe
    Role of propolis on biochemical parameters in kidney and heart tissues against L-NAME induced oxidative injury in rats
    (Taylor & Francis Inc, 2014) Talas, Zeliha Selamoglu; Ozdemir, Ilknur; Ciftci, Osman; Cakir, Oguz; Gulhan, Mehmet Fuat; Pasaoglu, Oguz Murat
    Nitric oxide (NO), produced by endothelial NO synthase, is recognised as a central antiinflammatory and antiatherogenic principle in the vasculature. Epidemiological and clinical studies have demonstrated that a growing list of natural products, as components of the daily diet or phytomedical preparations, may improve vascular function by enhancing NO bioavailability. In this article, we investigated antioxidant effects of propolis on biochemical parameters in kidney and heart tissues of acute NO synthase inhibited rats by N-omega-nitro-L-arginine methyl ester (L-NAME). There was increase (p < 0.001) in the activities of catalase and malondialdehyde levels in the L-NAME treatment groups when compared with control rats, but NO levels were decreased in both kidney and heart tissues. There were statistically significant changes (p < 0.001) in these parameters of L-NAME + propolis treated rats as compared with L-NAME-treated group. In summary, propolis may influence endothelial NO production.
  • [ X ]
    Öğe
    ROLE OF PROPOLIS ON OXIDATIVE STRESS IN VARIOUS TISSUES OF FISH
    (Parlar Scientific Publications (P S P), 2014) Aldemir, Osman Selcuk; Selamoglu, Zeliha; Gulhan, Mehmet Fuat; Cakir, Oguz; Ozdemir, Ilknur; Dastan, Sevgi Durna; Dogan, Husnu
    The aim of this study was to investigate the therapeutic effects of propolis on biochemical parameters in tissues of rainbow trout (Oncorhynchus mykiss) exposed to cypermethrin. Cypermethrin is a potential toxic pollutant that directly threats the aquatic ecosystems and environment. Sublethal cypermethrin concentration of 0.0082 ppm was applied to the fish for 96 h. Propolis is a natural product collected from plants by honey bees. Its polyphenolic components, caffeic acid derivatives and flavonoids in particular, are matter of interest because of their strong antioxidant properties. Therapeutic concentration of propolis has been determined as 10 ppm in a previous study. Herein, malondialdehyde (MDA) levels and catalase (CAT) activities were determined in spleen and heart tissues of rainbow trouts. Results showed that CAT activities and MDA levels increased (P <= 0.001) in tissues of fish exposed to cypermethrin compared to control group. CAT activities and MDA levels in the tissues of fish decreased in cypermethrin+propolis group (P <= 0.001) compared to cypermethrin group. Propolis (10 ppm) on the tissues of the rainbow trout showed significant therapeutic effects. Propolis may serve as an antitoxic agent against pesticide toxicity to aquatic animals.