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    Action plan to regain unnecessary deferred blood donors due to malaria risk in Turkey
    (Pergamon-Elsevier Science Ltd, 2012) Degirmenci, Aysu; Doskaya, Mert; Caner, Ayse; Nergis, Sebnem; Gul, Kadri; Aydinok, Yesim; Ertop, Tufan
    Malaria was expected to be a major problem during blood donation in Turkey due to existence of malaria cases in southeastern region of Turkey. The present study aimed for the first time, to investigate malaria in donors deferred for malaria risk and to determine the regional rates of malaria deferral in Turkey. Blood samples were collected from several Blood Banks of southeastern provinces where local malaria cases still exist and from Blood Bank of Ege University Medical School (EUMS) located in western Turkey where malaria is eradicated decades ago. Plasmodium spp. and specific antibodies were investigated by stained smears, antigen detection, PCR and ELISA. Among the donors deferred for malaria risk, Plasmodium spp. were not detected by microscopy, PCR or antigen detection. Sero-prevalances were 2% and 3.92% in western and southeastern regions, respectively. Rate of donor deferral for malaria risk was 0.9% in EUMS and deferrals were exclusively because of travel to southeastern Turkey. In southeastern provinces, deferrals were mainly due to malaria like fever history. The present study first time assessed regional rates of donor deferral due to malaria risk in Turkey. Previously, malaria was expected to be a major problem during blood donation in Turkey due to existence of malaria cases in southeastern region of Turkey. The results of the study showed that 97% of the deferrals were unnecessary. In conclusion, to reduce unnecessary donor deferrals in Turkey, in addition to comprehensive questioning for malaria history, the usage of a malaria antibody screening method should be initiated prior to deferral decision. (C) 2012 Elsevier Ltd. All rights reserved.
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    Cryptococcus liquefaciens meningitis in a patient with T cell non Hodgin lymphoma
    (Edizioni Minerva Medica, 2019) Ozcan, Nida; Dal, Tuba; Akpolat, Nezahat; Durmaz, Riza; Yakut, Salim; Zeybek, Hasan; Gul, Kadri
    Invasive fungal cryptococcosis including meningitidis is a growing threat to immunocompromised patients. Cryptococcus neoformans and Cryptococcus gattii are the main agents of human cryptococcosis. In recent years, there has been an increased incidence of opportunistic infections caused by other species, such as C. liquefaciens. In this study, we presented a meningitis case report caused by Cryptococcus liquefaciens in a 12 years old girl with T cell NHL (Non Hodgin lymphoma). A 12-year-old female patient with a diagnosis of T-NHL (T cell Non-Hodgkin's lymphoma) under the chemotherapy was hospitalized in Hematology Clinic with the complaints of fever and occasional headache for three days. The yeast colonies were isolated from cerebrospinal fluid material (CSF). MALDI-TOF MS (Matriks assisted laser desorption ionization time of flight mass spectrometry, Bruker Daltonics, USA) and Nested PCR (polymerase chain reaction) were used to identify the yeast. Isolated yeast is identified as Cryptococcus liquefaciens by MALDI-TOF MS and Nested PCR. In conclusion, C. liquefaciens can be a causative agent of menigitidis in cases with NHL. Nested PCR was a good, time-saving and economical method for the accurate and early diagnosis of C. liquefaciens infections. Our presented case also showed that result of MALDI-TOF method was compatible with nested PCR method in identification of C. liquefaciens.
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    Dissemination of blaOXA-48 like, blaNDM, blaKPC, blaIMP-1, blaVIM genes among carbapenem-resistant Escherichia coli and Klebsiella pneumoniae strains in Southeastern Turkey: first report of Klebsiella pneumoniae co-producing blaOXA-48-like, blaVIM and blaIMP-1 genes
    (Lippincott Williams & Wilkins, 2021) Bilik, Ozge Alkan; Bayraktar, Mehmet; Ozcan, Nida; Gul, Kadri; Akpolat, Nezahat
    Introduction: Carbapenem-resistant Enterobacterales (CRE) cause serious and life-threatening infections with limited treatment options. The most common causes of carbapenem resistance are carbapenemases. We aimed to determine the most prevalent carbapenemase genes; bla(NDM), bla(KPC), bla(IMP-1), bla(VIM), bla(OXA-48) like genes among Klebsiella pneumoniae and Escherichia coli strains in the southeast region of Turkey. Methods: Eighty-nine isolates (74 K. pneumoniae, 15 E. coli) were included in the study. The isolates were found as carbapenem-resistant by BD Phoenix automated system and Kirby Bauer disk diffusion test. Antibiotic susceptibility testing was performed by BD Phoenix automated system. Combination disc method (CDM) was also carried out as phenotypic method of carbapenemase detection. The presence of bla(NDM), bla(KPC), bla(IMP-1), bla(VIM) and bla(OXA-48)-like genes were investigated by Xpert CARBA-R (Cepheid, USA) multiplex PCR commercial system. Results: Antibiotic resistance rates by Phoenix were 48.3 97.8, 80.9, 96.6, 93.3, 96.6, 97.8, 69.7 and 97.8% for amikacin, aztreonam, cefepime, ceftazidime, ciprofloxacin, levofloxacin, moxifloxacin, trimethoprim sulfamethoxazole and piperacillin-tazobactam, respectively. The bla(OXA-48)-like gene was detected in 65 (73%); bla(NDM) gene in 4 (4.5%); co-production of bla(OXA-48)-like and bla(NDM) in 6 (6.7%); co-production of bla(OXA-48)-like, bla(VIM) and bla(IMP-1) genes in 1(1.2%) isolate. None of the bla(OXA-48)-like, bla(NDM), bla(VIM), bla(IMP-1), bla(KPC) genes were detected in 13 (14.6%) of the isolates. The sensitivity and specificity of CDM were calculated as 80 and 85% respectively. Conclusion: We detected bla(OXA-48)-like gene most frequently in our region. To our knowledge, this is the first report of K. pneumoniae-co-producing bla(OXA-48)-like, bla(VIM) and bla(IMP-1) genes. The coexistence of these genes is alarming and causes both infection control and treatment problems. Effective infection control measures are essential to prevent the spread of antibiotic resistance. Copyright (C) 2021 Wolters Kluwer Health, Inc. All rights reserved.
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    Distribution of ABO and Rh Blood Groups in Diyarbakir
    (Akad Doktorlar Yayinevi, 2008) Temiz, Hakan; Altintas, Abdullah; Gul, Kadri
    The detection of ABO and Rh system is important in transfusion medicine. In this study, we aimed to detect the profile of ABO and Rh blood groups in Diyarbakir region and provide new data on this subject. Among 206.673 individuals who applied to blood centers in Diyarbakir; 75.547 were (36.55%) A Rh(+), 61.385 were (29.70%) O Rh(+), 34.417 were (16.65%) B Rh(+), 12.944 were (6.26%) AB Rh(+), 8.806 were (4.26%) A Rh(-), 8.183 were (3.95%) O Rh(-), 3.897 were (1.88%) B Rh(-), 1.494 were (0.72%) AB Rh(-) blood group and Rh positivity was found in 184.293 cases (89.17%), as Rh(-) negativity was found in 22.380 cases (10.82%). There was little differences between the results of other regions of Turkey but blood group distribution in our region was similar with the results of all over the Turkey.
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    Microorganisms Isolated From Burn Wounds and Their Antibiotic Susceptibility
    (Oxford Univ Press, 2008) Mese, Sevim; Nergiz, Sebnem; Gul, Kadri; Girgin, Sadullah
    [Abstract Not Available]
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    Preliminary analysis of Plasmodium vivax genotypes isolated in southeastern Turkey
    (Springer Int Publ Ag, 2015) Doskaya, Aysu Degirmenci; Doskaya, Mert; Caner, Ayse; Gul, Kadri; Nergiz, Sebnem; Can, Huseyin; Guruz, Yuksel
    Plasmodium vivax is the most common cause of malaria worldwide as well as southeastern Turkey. After the implementation of a successful national elimination program that the local malaria cases were not reported in 2011, malaria returned to county of Savur located in southeastern Turkey in summer of 2012. The present study aimed to determine the prevalent P. vivax genotypes isolated from southeastern Turkey. Genetic polymorphism in P. vivax CSP gene was analyzed by PCR-RFLP to assess the ratio of VK210 and VK247 types. Blood samples were obtained from 15 patients who lived in southeastern between 2005-2006. According to the results, VK210 type was detected in 10 samples (66.6%), VK247 type was observed in three samples (20%). Remaining two samples showed mixed infection (13.3%). The results of the present study first time showed the ratio of P. vivax genotypes in southeastern Turkey before the elimination in 2011. The results of the present study will be enable researchers to compare the new isolates with the previously detected ones and design new treatment and/elimination strategies.