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    Intraperitoneal octenidindihydro-chloride-phenoxyethanol solution to prevent peritoneal adhesion formation in a rat peritonitis model
    (Wiley, 2007) Guezelsagqaltici, Nihat; Girgin, Sadullah; Gedik, Ercan; Bueyuekbayram, Hueseyin; Bac, Bilsel
    Background. Peritoneal adhesion is a common complication following abdominal surgery. Despite recent advances in diagnosis and treatment, it still presents a problem for the patients and surgeons. In the present study, we investigated the effects of octenidindihydro-chloride - phenoxyethanol (OCP) on peritoneal adhesions. Method. Rats were divided into four groups: Group 1 ( saline), Group 2 ( peritonitis plus saline), Group 3 ( OCP), and Group 4 ( peritonitis plus OCP). Peritonitis was induced in the rats of Groups 2 and 4. The abdominal cavities of the rats in Groups 1 and 2 were washed with saline, while those of the rats in Groups 3 and 4 were irrigated with 1: 10 OCP solution. Adhesion and fibrotic scores were determined by re-laparotomy after 21 days. Results. The adhesion scores in Groups 1 ( saline), 2 ( peritonitis plus saline), 3 (OCP) and 4 ( peritonitis plus OCP) were 3.30 +/- 0.94, 5.25 +/- 1.03, 1.12 +/- 0.83 and 0.28 +/- 0.48, respectively. Statistical analysis of adhesion scores revealed significant differences between groups, except between Groups 3 and 4 ( p = 0.265). Statistical analyses of grades of histopathological signs showed that Group 1 differed from Groups 2 and 4 ( p = 0.004, p = 0.003, respectively); Group 2 differed from Groups 3 and 4 ( p = 0.001, p = 0.001, respectively). On the other hand, differences between Group 3 and Groups 1 and 4 were not significant ( p = 0.06, p = 0.08, respectively). Conclusion. OCP decreased the peritoneal adhesion formation macroscopically and microscopically in the presence or absence of peritonitis. Peritoneal defects due to trauma are to be left open and OCP diluted 1: 1 should not be used intraperitoneally.