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    Antioxidant, anticholinesterase, and antimicrobial activities and fatty acid constituents of Achillea cappadocica Hausskn. et Bornm.
    (Tubitak Scientific & Technological Research Council Turkey, 2014) Ertas, Abdulselam; Boga, Mehmet; Hasimi, Nesrin; Yesil, Yeter; Goren, Ahmet Ceyhan; Topcu, Gulacti; Kolak, Ufuk
    This study was the first fatty acid analysis and biological activity report on an endemic Achillea species, Achillea cappadocica Hausskn. et Bornm. The major compounds in the fatty acid were identified as oleic (34.7%), palmitic (23.1%), and linoleic acids (20.6%). The methanol and water extracts indicated higher ABTS cation radical scavenging activity than that of alpha-tocopherol and BHT at 100 mu g/mL. The acetone extract showed 70.62% inhibitory activity against butyrylcholinesterase at 200 mu g/mL. The acetone and methanol extracts exhibited moderate antimicrobial activity.
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    Öğe
    Chemical Composition of The Essential Oils of Three Centaurea Species Growing Wild in Anatolia and Their Anticholinesterase Activities
    (Taylor & Francis Ltd, 2014) Ertas, Abdulselam; Goren, Ahmet Ceyhan; Boga, Mehmet; Demirci, Serpil; Kolak, Ufuk
    This report represents the first study on the chemical composition of essential oil of endemic Centaurea lycopifolia. This report also represents the first study on the anticholinesterase activity of essential oils of C. lycopifolia, C. balsamita and C. iberica. Essential oils were obtained using a Clevenger apparatus by hydrodistillation from the whole parts of C. lycopifolia, C. balsamita and C. iberica. The essential oils composition of the plants were determined by GC-FID and GC-MS (gas chromatograph/mass spectrometry) analysis. The major component of the essential oils was identified as caryophyllene oxide (9.7 %) and spathulenol (7.3 %) for C. lycopifolia, alpha-selinene (8.5 %) and hexatriacontane (8.3 %) for C. balsamita and arachidic acid (25.3 %) and hexadecanoic acid (5.9 %) for C. iberica. The essential oils of three Centaurea species indicated moderate inhibitory effect against butyrylcholinesterase and acetylcholinesterase enzyme, at 200 mu g/mL.
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    Öğe
    Chemical profile and biological activities of Veronica thymoides subsp pseudocinerea
    (Taylor & Francis Ltd, 2015) Ertas, Abdulselam; Boga, Mehmet; Kizil, Murat; Ceken, Bircan; Goren, Ahmet Ceyhan; Hasimi, Nesrin; Demirci, Serpil
    Context: In Turkey, Veronica species (Plantaginaceae) have been used as a diuretic and for wound healing in traditional medicine. Objective: To examine the fatty acid and essential oil profiles, the antioxidant, anticholinesterase, antimicrobial, and DNA damage effects of Veronica thymoides P.H. Davis subsp. pseudocinerea M.A. Fischer as a potential source of natural active compounds. Materials and methods: GC/MS was used to analyze essential oil and fatty acid obtained from whole plant. The antioxidant activity was evaluated by the beta-carotene-linoleic acid test system, DPPH-free and ABTS cation radicals scavenging, and cupric reducing antioxidant capacity assays. The anticholinesterase and antimicrobial activities were determined by Ellman and broth macrodillution methods, respectively. The effect of the methanol extract on DNA cleavage was investigated. Results: Hexatriacontene (21.0%) was found to be the main constituent in essential oil, and linoleic acid (25.2%) and palmitic acid (20.6%) in fatty acid. Methanol extract demonstrated the best IC50 values in lipid peroxidation (49.81 +/- 0.31 mu g/ml) and DPPH-free radical scavenging activity (15.32 +/- 0.17 mu g/ml). Methanol and water extracts possessed strong ABTS cation radical scavenging activity with IC50 values 9.15 +/- 0.28 and 8.90 +/- 0.14 mu g/ml, respectively. The acetone extract exhibited moderate butyrylcholinesterase inhibitory activity. The highest antimicrobial activity was determined in methanol extract against Escherichia coli with 31.25 mu g/ml MIC value. Inhibition of methanol extract on plasmid DNA cleavage by OH radicals was found to be 93.32% at 500 mu g/ml. Conclusion: The methanol extract having strong antioxidant and DNA damage effects could be investigated phytochemically to find natural active compounds.