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    Enteric Adenovirus Antigens in Children with Gastroenteritis
    (Turkish Soc Immunology, 2014) Kandemir, Idris; Atalay, Mustafa Altay; Delice, Safiye; Tas, Sevgi Kalkanli; Gokahmetoglu, Selma
    Objectives: This study aims to investigate the age and seasonal distribution of enteric adenovirus gastroenteritis in childhood. Patients and methods: The records of stool specimens of a total of 2,422 patients (968 females, 1454 males; mean age 3.6 years; range 0 to 16 years) admitted to our hospital with the complaint of acute gastroenteritis between January 2009 and December 2012 were retrospectively analyzed. Adenovirus serotype 40-41 antigens in the stool specimens were investigated through the immunochromatographic test. Results: Of a total of 2,422 stool specimens, 170 were found to have viral antigens. Most of the patients were between 0 and 2 years old (n=106; 62%). Enteric adenovirus infection was mostly seen during spring (8%) and it reached peak during August (11.2%). Conclusion: The detection of adenoviruses in acute gastroenteritis is important to prevent unnecessary antibiotic usage and to reduce the development of antibacterial resistance.
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    Six-year distribution pattern of hepatitis C virus in Turkey: a multicentre study
    (Taylor & Francis Ltd, 2016) Altindis, Mustafa; Dal, Tuba; Akyar, Isin; Karatuna, Onur; Gokahmetoglu, Selma; Ulger, Seda Tezcan; Kulah, Canan
    Hepatitis C infection is a public health problem. The aim of this retrospective study was to determine the distribution of hepatitis C virus (HCV) genotypes in seven regions of Turkey, by evaluating 7002 patients with chronic HCV in a six-year period. During the 2009-2014 period, serum/plasma samples from 7002 new consecutive HCV RNA positive patients were collected. The female patients were 3867 (55.2%). The genotype distribution of HCV patiens was evaluated by ages and years. Statistical analysis was performed by using the Mann-Whitney test and the chi(2) analysis. During the six-year period, genotype 1b was the most common genotype (67.7%) followed by untypeable genotype 1 (7.7%), genotype 4 (7.3%) and genotype 3 (6.7%). In 2014, genotype 3 was the second most common one (11.3%) and genotype 4 was the third most common one (9.8%). In the group with <25 years old patients, genotype 1b was most common (78.48%, 62/79) between the years of 2009 and 2011, whereas genotype 3 (34.8%, 86/247), between the years of 2012 and 2014. Genotype 1b was the most common in the groups between 26 and 35 years, 36 and 45 years, 46 and 55 years, 56 and 65 years. The rate of genotype 3 was increased from 4.78% to 10.06% and the rate of genotype 4 was increased from 1.3% to 3.84%, from 2009-2011 to 2012-2014. In recent years, genotypes 3 and 4 have gained importance. New therapeutic strategies and survey studies may be required for the modified HCV genotype pattern.