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Comparison of bupivacaine and bupivacaine with fentanyl in epidural analgesia during labour
(1997) Tok D.; Ganidagli S.; Ozyilmaz M.A.; Turhanoglu S.; Yayla M.; Bayhan N.
We have studied 50 healthy women who were in the first stage of labour and requesting epidural analgesia. They were allocated randomly in a double-blind fashion to receive either 15 cc 0.133% plain bupivacaine (group 1) 15 cc 0.133% plain bupivacaine + 100 ?g fentanyl (group 2) and when requested 15 cc 0.133% bupivacaine was given via the epidural route. Efficacy of analgesia was evaluated using linear visual analogue scoring (VAS) and verbal pain score (VPS). Maternal and fetal cardiovascular variables: maternal respiration rate (MRR) were measured continuously. The reduction in VAS and VPS was greater and the onset time of analgesia was shorter in group 2. Analgesia was associated with a reduction in arterial pressure in both groups but the haemodynamic alterations and the reduction in MRR were considered to be insignificant. Fetal heart rate didn't change side effects were insignificant and this study shows that epidural bupivacaine or bupivacaine + fentanyl combination provide effective analgesia and appeared to be safe for the mother and the child.