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    Öğe
    Diagnosis of leptomeningeal metastases disease in MRI images by using image enhancement methods
    (Zarka Private University, 2017) Gül M.; Kara S.; Işıkdoğan A.; Yarar Y.
    Leptomeningeal Metastases (LM) disease is the advanced stages of some complicated cancers. It contaminates in the Cerebrospinal Fluid (CSF). Tumors might be in macroscopic or microscopic sizes. The medical operation is more risky than other cancers. Consequently, diagnosis of leptomeningeal metastases is important. Different methods are used to diagnose LM disease such as CSF examination and imaging systems Magnetic Resonance Imaging (MRI) or Computer Tomography (CT) examination. CSF examination result is more accurate compared to CT or MRI imaging systems. However imaging systems’ results are taken more early than CSF examination. Some details in MRI images are hidden and if the proper image enhancement method is used, the details will be revealed. Diagnosis of LM disease can be earlier with accurate results at that time. In this study, some image enhancement methods were used. The probability of result of Logarithmic Transformation (LT) method and Power-Law Transformation (PLT) method were almost the same and result was p=0.000 (p<0.001), and statistically high result was obtained. The probability of Contrast Stretching (CS) method was p=0.031 (p<0.05), and this result was statistically significant. The other four methods’ results were insignificant. These methods are Image Negatives Transformation (INT) method, thresholding transformations method; Gray-Level Slicing (GLS) method and Bit-Plane Slicing (BPS) method. © 2017, Zarka Private University. All rights reserved.
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    Öğe
    Evaluation of the antioxidant and renoprotective effects of ellagic acid on ischemia / reperfusion induced nephropathy in rats
    (Acta Medica Mediterranea, 2014) Yildirimi Y.; Aba Adıyaman, Özlem; Yilmaz Z.; Kadiroglu A.K.; Yilmaz M.E.; Gül M.; Ketani A.
    Aims: Renal ischemia-reperfusion (I/R) injury is one of the important cause of acute kidney injury (AKI). Reactive oxygen species and inflammatory cytokines play major role in the pathogenesis of IR injury. Ellagic acid (EA), a phenolic compound, have shown to exert antioxidants, anti-inflammatory, anticarcinogenic, antihyperlipidemic effects. We aim to evaluate, the effect of EA on renal I/R induced nephropathy in rats. Materials and methods: Twenty-eight male Sprague-Dawley rats were divided into four groups; control, control + EA, I/R, and EA+I/R. EA (85 mg/kg, perorally) was administered 30 min prior to the ischemia. Rats were unilaterally nephrectomized and subjected to 45 min of renal pedicle occlusion followed by 60 min of reperfusion. Both groups were subsequently studied by renal function tests, oxidant and antioxidant parameters, and kidney histology. Results: Serum/kidney TAC, NO and paraoxonase levels were significantly higher, while serum urea and creatinine, serum/kidney MDA and TOS were significantly lower in EA+I/R group compared to I/R group (p<0.05). Histopathologic examination revealed that the severity of damage was significantly lower in the EA+I/R group compared to the I/R alone group. Conclusion: Administration of EA appears to have beneficial effects on I/R induced renal injury by reducing oxidative stress, thus preventing histological injuries and bringing about an improvement in renal function.