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  • Küçük Resim
    Öğe
    Deneysel diyabetik nefropati modelinde ghrelinin rolü
    (Dicle Üniversitesi, Sağlık Bilimleri Enstitüsü, 2020) Gül, Cihan; Kelle, Mustafa
    Amaç: Bu tezdeki amaç; ghrelinin diyabetik nefropatinin (DNp) oluşumundaki rolünü araştırmaktır. Ayrıca çalışmada diyabetik rat modelinde DNp oluşumunun önlenebilmesi ve hastalığın tedavisinde ghrelinin muhtemel etkilerini araştırmayı amaçladık. Gereç ve Yöntem: Deneyde 8-10 haftalık 63 erkek Wistar Albino sıçanlar rastgele 9 gruba ayrıldı. Diyabetik gruplar: DD-1=1.Diyabetik Deney Grubu(n=7) [1 haftalık diyabet], DD-2: 2.Diyabetik Deney Grubu(n=7) [3 haftalık diyabet], DD-3=3.Diyabetik Deney Grubu(n=7) [6 haftalık diyabet], DD-4=4.Diyabetik Deney Grubu(n=7) [8 haftalık diyabet] ve MT: Metformin Tedavi Grubu(n=7) [8 haftalık diyabet] olarak isimlendirildi. Kontrol grupları: NDK-1=1.Non-Diyabetik Kontrol Grubu (n=7), NDK-2=2.Non-Diyabetik Kontrol Grubu(n=7), NDK-3=3.Non-Diyabetik Kontrol Grubu(n=7) ve NDK-4=4.Non-Diyabetik Kontrol Grubu(n=7) olarak isimlendirildi. Diyabet oluşturmak için sıçanlara sitrat tamponunda hazırlanmış olan streptozotosin (STZ) çözeltisinden 35 mg/kg tek doz intraperitoneal olarak uygulandı. MT grubuna diyabet oluşturulduktan sonra oral metformin 100 mg/kg/gün antidiyabetik olarak verilmiştir. Bulgular: DD-4 ve NDK-4 grupları arasında plazma ghrelin, plazma anjiyotensin II idrar kreatinin, serum kreatinin, son ağırlık, ilk ve son AKŞ'ler arasında anlamlı fark bulunmuştur(P<0.01). Tüm sıçanların toplam plazma ghrelin seviyeleri ile idrar kreatinin ve son ağırlıkları arasında istatistiksel olarak pozitif yönde anlamlı fark bulunmuştur(P<0.01). Tüm sıçanların toplam plazma ghrelin seviyeleri ile plazma anjiyotensin II, ilk ve son açlık kan şekerleri (AKŞ) arasında istatistiksel olarak negatif yönde anlamlı fark bulunmuştur(P<0.01). Sonuç: Sonuç olarak çalışmamızda sıçanlarda STZ ile oluşturulmuş diyabet sonrası sıçanlarda plazma ghrelin seviyesi diyabet ilerledikçe azalmasına karşılık plazma anjiyotensin II ve serum kreatinin seviyesinin ise arttığı görülmüştür. Bu durum DNp'nin gelişmesinde plazma ghrelin seviyesininde etkisi olduğunu göstermektedir. Ghrelinin diyabetik hastaların tedavisine eklenmesi DNp'nin gelişmesini önleyebileceği ya da oluşmasını geciktirebileceğini göstermektedir.
  • Küçük Resim
    Öğe
    The effects of rosuvastatin and pravastatin on bone metabolism in diabetic rats
    (İnönü Üniversitesi Tıp Fakültesi, 2021) Gökdemir, Gül Şahika; Gökdemir, Mehmet Tahir; Kayhan, Hacer; Yokuş, Beran; Taşdemir, Ezel; Gül, Cihan; Baylan, Mukadder
    Aim: In this study, the effects of rosuvastatin and pravastatin on bone metabolism were evaluated. Comparison of the positive or negative effects of two different statins on biochemical parameters related to bone metabolism in 20 mg / kg / day diabetic rats will be contribute to the enrichment of the literature on this subject. In addition, information will be obtained about whether the use of statins will be beneficial in bone metabolism disorders that may occur due to aging or diabetes in DM patients. Materials and Methods: In a diabetic rat model induced by Streptozotocin (STZ), the possible effects of Rosuvastatin and Pravastatin, both of which are hydrophilic, on biochemical parameters and histologycal examination related to bone metabolism (20 mg / kg) were examined in comparison with the control groups. Results: In the intergroup comparisons, Phosphate (P) level was lower in the Pravastatin group than the controls (P = 0.017). However, there was no difference in the P level in the Rosuvastatin group compared to the control group and the diabetes group. The calcium (Ca) level was increased in the Rosuvastatin group then the the controls (P = 0.002). However, there was no significant change in Ca level in the Pravastatin group. The vitamin D2 level of rats was similar in all groups and was not statistically significant. There was no significant difference between the groups in terms of both osteoblastic activity and bone marrow cellularity. Conclusion: In conclusion, although more extensive studies are needed, our study revealed that the serum Ca level was high in rats given rosuvastatin, and P levels were low in rats given pravastatin. But cytologically, there was no change in bone structure. Our study revealed that we should be a little more cautious about the information that statins have a positive effect on bone tissue.
  • [ X ]
    Öğe
    Time-dependent changes in changes in plasma ghrelin and angiotensin II levels in the diabetic nephropathy model
    (Parlar Scientific Publications, 2021) Gül, Cihan; Kelle, Mustafa; Baylan, Mukadder; Yokuş, Beran; Taşdemir, Ezel
    Ghrelin is an appetite-enhancing anabolic hormone secreted from the stomach. Angiotensin II maintains sodium and potassium levels in body fluids and plays a very important role in the regulation of arterial blood pressure. Although their relationship with Type 2 diabetes and complications have been reported, their role in diabetic nephropathy is not fully understood. We investigated time dependent possible changes in plasma ghrelin and angiotensin II levels during the development and progression of diabetic nephropathy in experimental diabetic rat model. Adult 63 male Wistar Albino rats were randomly divided into 9 groups as 4 control (C1-C4), 4 diabetic (D1-D4) and one treatment (T) group. Group D1, sacrificed by cardiac puncture one week after diabetes, group D2 three weeks later, group D3 six weeks later, and groups D4 and T eight weeks later. Antidiabetic treatment was not administered to the D1-D4 group diabetic rats. Group T diabetic rats were treated with antidiabetic metformin (100 mg / kg / day) for 8 weeks. A single dose of 35 mg / kg intraperitoneal streptozotocin was administered to the rats to induce diabetes. Significant differences were found between the D4 and C4 groups in body weight, plasma glucose, ghrelin and angiotensin II, serum and urine creatinine levels. While there was a linear (positive) relationship between plasma ghrelin levels of all rats and urinary creatinine and creatinine clearance and body weight, negative correlations were found between plasma ghrelin and angiotensin II levels and fasting blood glucose levels of all rats. During the progression of diabetes and the development of diabetes-related nephropathy, plasma angiotensin and serum creatinine levels increased, while plasma ghrelin levels decreased over time. Therefore, it was concluded that changes in plasma ghrelin and angiotensin II levels in diabetic rats may be associated with the pathogenesis of diabetic nephropathy