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    Effects of sodium nitroprusside on ischemia-reperfusion injury
    (TIP ARASTIRMALARI DERNEGI, 2010) Yavuz C.; Çakir O.; Göz M.; Kale E.; Uzunlar A.K.
    Aim: The aim of this study was to investigate the effects of sodium nitroprussid (SNP) on ischemia-reperfusion injury in rats. Method: Twenty-four Sprague-Dawney rats were divided into four equal groups: group I without ischemia-reperfusion (I-R); group II with ischemia; group III with I-R; group IV with I-R and SNP. Complete bilateral hindlimb ischemia was produced by means of tourniquet occlusion of the upper thigh. Result: Blood creatine phosphokinase, lactate dehydrogenase, aspartate transaminase, urea, creatinine levels were not significantly different between groups 3 and 4. Malondialdehyde (MDA) levels were not significantly different between groups 3 and 4 in liver, soleus muscles and lung tissue. However, MDA levels were significantly lower in group 4 when compared with group 3 in renal tissue. Histological examination of the soleus muscles revealed that neutrophil leukocyte infiltration in group 3 was significantly less prominent than in group 4. Conclusion: These results have shown that SNP was not able to improve muscle ischemia-reperfusion injury in our study.
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    Öğe
    Massive hemolysis due to dacron patch leakage following repair of ventricular septal defect
    (2006) Göz M.; Çakir Ö.; Kilinç N.; Eren M.N.
    Massive hemolysis following closure of a ventricular septal defect (VSD) is rarely encountered complication. In this article, a case of 30 years-old male developed a severe degree of intravascular hemolysis within 24 hours due to residual shunt after a Dacron patch closure of ventricular septal defect. In early period, corticosteroid treatment was effective. To report, we discussed that corticosteroid therapy can be attempted before early reoperation.