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Öğe Cutaneous and scalp metastases of pancreatic carcinoma: Case report(2011) Küçüköner M.; Kaplan M.A.; Inal A.; Sula B.; Firat U.; Uçmak F.; Işikdoğan A.Pancreatic carcinomas are very rapidly progressing tumors. Approximately 50% patients with newly diagnosed pancreatic cancer have many kinds of metastases. The most frequent sites of metastasis of the pancreatic carcinomas are the lymph nodes, lungs, liver, adrenal glands, kidneys and bones. Cutaneous metastases from pancreatic adenocarcinomas are very rare, far less common sites of pancreatic metastases are the scalp and skull metastases. The most common site of cutaneous metastasis is the umbilicus, there are scant reports of pancreatic cutaneous metasta sis at nonumbilical areas. In the literature, togetherness of cutaneous, scalp and skull metastases have not usually been reported and in our interesting case, we present these rare metastases together. Copyright © 2011 by Türkiye Klinikleri.Öğe Diploid karyotype partial mole coexisting with live term fetus-Case report and review of the world literature(Via Medica, 2012) Sak M.E.; Soydinc H.E.; Evsen M.S.; Sak S.; Firat U.A partial molar pregnancy of diploid karyotype coexisting with live term fetus is a rare entity. Most instances of partial mole are triploid and only a few cases of diploid partial moles with term delivery have been reported. Here, we report a case of partial mole concomitant with a 37-week live fetus. Postpartum karyotype of the placenta and the fetus revealed both as 46XX. Histological examination of the placenta showed a partial hydatidiform mole. We discuss the diagnosis based on presenting clinical picture and proper management of signs and symptoms of partial molar pregnancy coexisting with live term fetus and diploid karyotype, coupled with a review of the literature. © Polskie Towarzystwo Ginekologiczne.Öğe Effects of Malathion in fetal kidney tissues in pregnant rats: Teratogenic effects induced by different doses(Veteriner Fakultesi Dergisi, 2012) Alp H.; Sak M.E.; Evsen M.S.; Firat U.; Evliyaoglu O.; Penbegul N.; Sancaktutar, Ahmet AliThe aim of this study was to investigate the teratogenic effects of Malathion (ML) induced by different doses on fetal kidney tissues in pregnant rats. A total of 28 Sprague-Dawley pregnant rats were randomly divided into 4 groups of 7 rats each. Depending on ML dose, four groups were formed, including (I) control, (II) ML 2.5 (ML 2.5 mg/kg/day, orally), (III) ML 5 (5 mg/kg/day, orally), and (IV) ML 10 (10 mg/kg/day, orally). ML application started when the male and female were put together (when mating started). Daily ML application was continued until birth. It was determined that in parallel with dose of ML, ML resulted in toxic effects on serum enzymes (acetyl-cholinesterase (AChE), amylase and lipase) and kidney tissues of pregnant rats, and also -regardless of ML dose in fetal kidneys- it led to teratogenic effects in all the doses. Biochemical data wasconfirmed by histopathologic data. We concluded that ML leads to kidney damage in both pregnant and fetal rats as a result of its teratogenic and toxic effects.Öğe Protective effect of caffeic acid phenethyl ester in rat cerebral ischemia/reperfusion damage(Turkish Neurosurgical Society, 2011) Uzar E.; Acar A.; Firat U.; Evliyaoğlu O.; Alp H.; Tüfek A.; Yavuz C.Objective: Because oxidative stress is related to cerebral ischemia/reperfusion (I/R) injury, modulation of oxygen free radical production may represent a new approach to the management of cerebral I/R. Caffeic acid phenethyl ester (CAPE) has been determined to have neuroprotective, antioxidant, anti-inflammatory, and anti-apoptotic activities. The aim of this study was to investigate whether CAPE has a protective effect on cerebral I/R damage, and to determine the possible effects of CAPE on total antioxidant/oxidant status. Methods: A total of 30 rats were randomly divided into three groups as control group, I/R group, and I/R + CAPE. Total oxidant status (TOS), total antioxidant status (TAS) and oxidative stress index (OSI) levels and histopathological cellular structures were evaluated in cerebral tissues obtained after the experiment procedure in all groups. Results: In the brain tissue, TOS and OSI levels were found to be significantly increased in the I/R group compared to the controls (p= 0.023, p= 0.001, respectively). Significantly decreased TAS levels were found in the I/R group compared to the controls (p= 0.001). CAPE treatment prevented the increase in TOS and OSI that is produced by cerebral I/R (p= 0.041, p= 0.001, respectively). TAS was found to be increased in the CAPE + I/R group compared with the I/R group (p= 0.002). In the I/R group, the brain sections showed findings of cerebral I/R damage including inflammation, vascular congestion and necrosis (for both variables, p= 0.001). These histopathological cerebral damage findings were found to be significantly reduced in the CAPE + I/R group compared to the I/R group (for both parameters, p< 0.05). Conclusion: In this study, it was found that oxidative stress had an important role in the pathogenesis of cerebral I/R damage, and histopathological and biochemical evaluations showed significantly decreased I/R damage following CAPE treatment in rats.Öğe The protective effect of dexmedetomidine on bupivacaineinduced sciatic nerve inflammation is mediated by mast cells(2013) Tüfek A.; Kaya S.; Tokgöz O.; Firat U.; Evliyaoğlu O.; Çelik F.; Karaman H.Purpose: This study was designed to assess the correlation between the neuroprotective effect of dexmedetomidine and oxidative stress, neural inflammation and mast cell stability in rats with bupivacaine-induced sciatic nerve toxicity. Methods: Forty adult Wistar Albino rats, eight rats per group, were used. Saline (0.3 ml of 0.9%), dexmedetomidine (20 ?g/kg), 0.5% bupivacaine or 0.5% bupivacaine+dexmedetomidine (20 ?g/kg) was injected into the sciatic nerve. A control group of rats received no injection. Fourteen days after injection, the sciatic nerves were harvested and total oxidant status, total anti-oxidant status, paraoxonase-1, galectin-3 and matrix metalloproteinase 2 and 9 levels were measured in the sciatic nerves. In addition, the presence and status of inflammation, edema, and mast cells were evaluated histopathologically. Results: The combination of dexmedetomidine and bupivacaine alleviated oxidative stress. In addition, it decreased matrix metalloproteinase 9 and galectin-3 levels and increased matrix metalloproteinase 2 levels. Moreover, it stabilized recruited mast cells at the injury site; however, it did not significantly decrease inflammation or edema. Conclusion: Dexmedetomidine may ameliorate bupivacaine-induced neurotoxicity by modulating mast cell degranulation. The neuroprotective effect of dexmedetomidine may make it a suitable adjuvant agent to local anesthetics in peripheral nerve blocks.Öğe The protective effect of ellagic acid against renal ischemia-reperfusion injury in male rats(Veteriner Fakultesi Dergisi, 2012) Bozkurt Y.; Firat U.; Atar M.; Sancaktutar, Ahmet Ali; Pembegul N.; Soylemez H.; Yuksel H.The aim of this study was to evaluate the possible protective effect of ellagic acid (EA) on rats following renal ischemia-reperfusion (I/R) injury. Twenty-four Wistar rats were divided into three groups. Sham group underwent laparotomy then waited for 45 min without ischemia. I/R group were subjected to left renal ischemia for 45 minutes followed by 60 min of reperfusion. I/R+EA group were subjected to the same renal ischemia/reperfusion as the I/R group, were also given 85 mg/kg EA perorally 30 min prior to the ischemia. Malondialdehyde (MDA), total antioxidant capacity (TAC), total oxidant status (TOS), and oxidative stress index (OSI) were determined on the blood samples and kidney tissues. Histopathological analyses were conducted on the kidney tissues. I/R damage significantly increased serum MDA levels in the I/R group when compared with Sham group. Serum TAC level was significantly lower in I/R group than I/R+EA group. A significantly increase on OSI levels and decrease on TAC levels was found in the kidneys in I/R group. In I/R + EA group, EA reversed the negative effects of I/R injury. EA pretreatment was effective in decreasing tubular necrosis score. In conclusion; EA pretreatment ameliorated the oxidative damage and histopathological changes occurring following renal I/R injury.Öğe Rate of microscopic colitis and cytokine levels in patients with irritable bowel syndrome(Acta Medica Mediterranea, 2015) Uçmak F.; Göral V.; Firat U.; Mete N.Aims: The aim of this study is to determine the rate of microscopic colitis (MC) among patients diagnosed as Irritable Bowel Syndrome (IBS) in accordance with Roma III criteria and to investigate the correlation of cytokine levels with the type of IBS and presence of MC. Methodology: A total of Eighty-nine patients who were diagnosed with IBS based on Rome III diagnostic criteria were included in this study. Biopsies taken from caecum, ascending colon, transverse colon, descending colon and rectosigmoid region during colonoscopy were put in separate tubes and histopathologically examined. In addition, serum TNF-?, IL-1? and IL-6 levels were determined in peripheral blood samples of patients. Results: The frequency of MC was higher in the study groups compared to the general population (22.5% and 20.4% in IBS-D and IBS-C groups, respectively). Specimens taken from caecum, ascending colon, transverse colon and descending colon were more likely to lead to the diagnosis of MC compared to those taken from rectrosigmoid region (p<0.001). No significant difference was found between presence of MC and IL-1?, IL-6 and TNF-? levels. In addition, TNF-? levels were significantly higher in the IBS-C group (p= 0.013). Conclusion: Rate of MC in IBS patients is higher than the rate in normal population. In IBS patients, biopsy samples obtained solely from rectosigmoid area is not sufficient to preclude MC diagnosis. No difference exists between IBS patients with and without MC in terms of cytokine levels.
