Yazar "Firat, Ela Tules" seçeneğine göre listele

Listeleniyor 1 - 6 / 6
  • [ X ]
    Öğe
    Bidirectional Relationship Between Diabetes Mellitus and Periodontitis
    (Ortadogu Ad Pres & Publ Co, 2009) Firat, Ela Tules; Dag, Ahmet
    Numerous oral changes have been described in diabetics. The influence of diabetes on the periodontium has been thoroughly investigated. Although it is difficult to make definitive conclusions about the specific effects of diabetes on periodontium, very severe gingival inflammation, deep periodontal pockets, rapid bone loss, and frequent periodontal abcesses often occur in diabetic patients with poor oral hygiene. Recent studies suggest that uncontrolled or poorly controlled diabetes is associated with an increased susceptibility and severity of infections including periodontitis. Studies showed that subjects with type 2 diabetes had approximately threefold increased odds of having periodontitis compared with non-diabetics. Recent data indicate periodontitis is much more than a localized oral infection. It is a chronic subclinical infection that may cause changes in systemic physiology. Periodontal disease has been reported as the sixth complication of diabetes, along with neuropathy, nephropathy, retinopathy, and micro-and macrovascular diseases. Both diseases are thought to share a common pathogenesis that involves an enhanced inflammatory response that can be observed at the local and systemic level. Many studies have been published describing the bidirectional interrelationship between diabetes and periodontal disease. The main influences of diabetes on periodontal disease appear to be related to alterations in host immunoinflammatory reactions and tissue homeostasis. The increased response of monocytes and macrophages from diabetic patients may be related to the interaction of elevated levels of advanced glycated end-products (AGEs) in the periodontium with AGE receptors on these immune cells. However, chronic gramnegative periodontal infections increase insulin resistance and negatively impact glycemic control.
  • [ X ]
    Öğe
    The effect of low-level laser therapy on the healing of hard palate mucosa and the oxidative stress status of rats
    (Wiley, 2014) Firat, Ela Tules; Dag, Ahmet; Gunay, Ahmet; Kaya, Beyza; Karadede, Mehmet Irfan; Kanay, Berna Ersoz; Ketani, Aydin
    [Abstract Not Available]
  • [ X ]
    Öğe
    Effect of rifampin in combination with allogeneic, alloplastic, and heterogenous bone grafts on bone regeneration in rat tibial bone defects
    (Elsevier Science Inc, 2015) Kaya, Alper; Kaya, Beyza; Aktas, Ayfer; Firat, Ela Tules
    Purpose: The aim of this study was to evaluate the efficacy of rifampin with allogeneic, alloplastic, and heterogeneous bone graft substitutes on osteogenesis of experimentally created bone defects in rat tibias. Materials and methods: Twenty-eight male Wistar albino rats were used in this study. In each animal, two bone defects (10 mm length x 3 mm width x 2 mm depth) were created in the left and right tibias, respectively. The animals were divided into four groups. In Group 1, the right defects were irrigated with rifampin alone, and the left defects were irrigated with sterile saline alone. In Group 2, the right defects were filled with rifampin and allogeneic bone graft, and the left defects were filled with allogeneic bone graft alone. In Group 3, the right defects were treated with rifampin and alloplastic bone graft, and the left defects were filled with alloplastic bone graft alone. In Group 4, the right defects were filled with rifampin and heterogeneous bone graft, and the left defects were filled with heterogeneous bone graft alone. Results: The animals were sacrified on the 21st postoperative day. Histopathological analysis of samples was performed to evaluate the process of bone regeneration and the presence of spongeous bone, cortex bone, and bone marrow. Bone union (p = 0.023) and spongeous bone (p = 0.030) values were higher in Group 1A (rifampin alone) than those in Group 1B (saline alone). Bone union (p<0.001) and spongeous bone (p<0.001) values in Group 2B (allograft + saline) were higher than those in Group 2A (allograft + rifampin). These differences were statistically significant. Conclusions: Topical rifampin can accelerate the bone repair process, but the combination of rifampin and allogeneic bone grafts can also reduce new bone formation in osseous defects. Further studies involving long-term follow-up with a larger number of cases and different antibiotic agents should be conducted. These will provide additional data regarding new bone formation, especially in contaminated bone defects, resulting from use of antibiotic-supplemented bone grafts. (C) 2013 Asian AOMS, ASOMP, JSOP, JSOMS, JSOM, and JAMI. Published by Elsevier Ltd. All rights reserved.*
  • [ X ]
    Öğe
    The Effects of Low-Level Laser Therapy on Palatal Mucoperiosteal Wound Healing and Oxidative Stress Status in Experimental Diabetic Rats
    (Mary Ann Liebert, Inc, 2013) Firat, Ela Tules; Dag, Ahmet; Gunay, Ahmet; Kaya, Beyza; Karadede, Mehmet Irfan; Kanay, Berna Ersoz; Ketani, Aydin
    Objective: The biostimulation effects of low-level laser therapy (LLLT) have recently been demonstrated. In this study, we aimed to investigate the effects of LLLT on palatal mucoperiostal wound healing and oxidative stress status in experimental diabetic rats. Materials and methods: Forty-two male Wistar rats that weighed 250-300 g were used in this study. Experimental diabetes was induced in all of the rats using streptozotocin. A standardized full thickness wound was made in the mucoperiosteum of the hard palates of the rats using a 3 mm biopsy punch. The rats were divided into groups: 1 (control group, non-irradiated), and 2 (experimental group, irradiated). Treatment using a GaAlAs laser at a wavelength of 940 nm and at dose of 10 J/cm(2) began after surgery, and was repeated on the 2nd, 4th, and 6th days post-surgery. Seven animals from each group were killed on the 7th, 14th, and 21st day after surgery. Biopsies were performed for the histological analysis and blood samples were collected by cardiac puncture for biochemical analysis. Results: The histopathological findings revealed reduced numbers of inflammatory cells, and increased mitotic activity of fibroblasts, collagen synthesis, and vascularization in rats in group 2. The total oxidative status was significantly decreased in the laser-treated group on the 21st day. Conclusions: LLLT elicits a positive healing effect on palatal mucoperiostal wounds, and modulates the oxidative status in experimental diabetic rats.
  • [ X ]
    Öğe
    HISTOLOGICAL EXAMINATION OF THE EFFECTS OF LOW-LEVEL LASER THERAPY ON HEALING OF GINGIVA AFTER GINGIVECTOMY IN RATS
    (Taylor & Francis Ltd, 2013) Firat, Ela Tules; Dag, Ahmet; Gunay, Ahmet; Kanay, Berna Ersoz; Ketani, Sennur; Ketani, M. Aydin
    Lasers in dentistry find an increasing usage in recent years. The aim of this study was to assess the effects of low-level laser therapy (LLLT) on healing of gingiva after gingivectomy in rats. Forty-two male Wistar rats, 250 g to 300 g in weight, were used in this study. Gingivectomy was made to gingiva of mandibular incisors in all rats. The rats were divided into: group 1 (control group, non-irridated), and group 2 (experimental group, irridation-treated). After gingivectomy, a low-level laser therapy (LLLT) was applied to the side of the operation area. Treatment using a GaAlAs laser at a wavelength of 940 nm and a dose of 10 J/cm(2) began after surgery and was repeated on the 2nd, 4th and 6th day post-surgery. Seven animals from each group were sacrificed on the 7th, 14th and 21st day after surgery. Biopsies were performed for histological analysis. In the laser-treated grup, the histopathological findings revealed increased mitotic activity of fibroblasts and collogen synthesis on the 7th day, better formed epithelial layer, mild keratinization, collagen fibers and vascularization on day 14. On the 21st day after surgery, marked collagen fibers and vascularization was assesed according to the control group. The results of this study indicate that low-energy level laser therapy appeared to exert a positive effect in epithelization and wound healing after gingivectomy.
  • [ X ]
    Öğe
    Histological investigation of the impact of streptozotocin-induced experimental diabetes on the healthy gingivae of rats
    (Taylor & Francis Ltd, 2014) Dag, Ahmet; Firat, Ela Tules; Uysal, Ersin; Ketani, Sennur; Ketani, Muzaffer Aydin
    This study was aimed at the histological investigation of the impact of experimental diabetes on the healthy gingiva of rats. Thirty male Wistar rats were used in this study. The animals were randomly divided into two groups (n = 15) prior to the experiment. Group 1 experimental diabetes was created by streptozotocin injection in 15 rats. Group 2 comprised the control group (15 rats). On the 7th, 14th and 21st days after the induction of diabetes by streptozotocin, five animals from each group were euthanized by cardiac puncture. The gingiva of the maxillary left first molar tooth of the sacrificed animals was extracted for histological examination. Histological examination demonstrated that, when compared to the control group, the diabetes group displayed marked hyperkeratosis and parakeratosis of the gingival epithelium on day 21 post-induction. Furthermore, the diabetes group presented with an increased number of inflammatory cells and vasodilatation of the capillaries, in comparison to the controls. The overall evaluation of the findings obtained in this study suggested that diabetes alone could cause changes in the periodontium and affect periodontal health.