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Öğe Effect of multiple-dose administration of cefquinome on hematological and biochemical parameters in horse(Dicle Üniversitesi Veteriner Fakültesi, 2019) Altan, Feray; Erol, Hanifi; Altan, Semih; Arıcan, Mustafa; Elmas, Muammer; Üney, KamilSefkuinomun (CFQ) çoklu doz uygulamalarının, atların hematolojik ve biyokimyasal profilleri üzerinde bir etkisi olup olmadığı bilinmemektedir. Bu çalışmanın amacı, atlarda çoklu artan CFQ dozlarının bazı hematolojik (WBC, LYM, MON, GRA, RBC, HB, HT, MCV, MCH, MCHC, RDW ve PLT) ve biyokimyasal parametreler üzerine (ALB, ALP, ALT, AST, CH, CR, GGT, LDH, TB, TP, TRIG ve BUN) etkisini belirlemektir. Araştırma 16 adet erişkin at (4.6 ± 2.1 yaş, 302 ± 38 kg) üzerinde gerçekleştirildi. Atlara damar içi olarak 7 gün boyunca her 12 saatte dört doz seviyesinde CFQ uygulandı: Grup I; 1 mg/kg, Grup II; 2 mg/kg, Grup III; 4 mg/kg, Grup IV; 6 mg/kg) uygulanan toplam 13 enjeksiyon gerçekleştirildi. Belirlenen hematolojik ve biyokimyasal parametreler ilaç uygulamasından önce (0 gün) ve ilk CFQ dozunun uygulanmasından 1, 3, 7 ve 14 gün sonra izlendi. Tedavi günlerinde gruplar arasında serum biyokimyasal parametrelerinde anlamlı bir fark bulunmadı (p> 0.05). Hematolojik parametrelerde (MONO, GRAN, RBC, HB, HCT, MCH ve PCT) doz grupları arasında referans değerler içinde anlamlı farklar bulundu (p <0.05). Bu sonuçlar, atlarda CFQ’un 6 mg/kg kadar çoklu doz uygulamalarının, değerlendirilen kan parametreleri üzerinde klinik olarak önemli bir etkisi olmadığını göstermektedir.Öğe Hematologic, Blood Gas, Cardiac Biomarkers and Serum Biochemical Parameters in Calves with Atresia Coli and Theirs Relationship with Prognosis(Univ Fed Rio Grande Do Sul, 2017) Coskun, Alparslan; Aydogdu, Ugur; Altan, Semih; Erol, Muharrem; Erol, Hanifi; Guzelbektes, Hasan; Sen, IsmailBackground: Atresia coli is an intestinal anomaly. Generally, absence of defecation in calves less than 10 days old, diminishing appetite, progressing abdominal distention and time-developing depression are reported in atresia coli. Although a calf consumes its milk normally in first days, loss of appetite develops over time. Occasional minor pain indications are observed. The objective of this study was to evaluate of hematologic, blood gases, cardiac biomarkers and serum biochemical parameters before operation in calves with atresia coli, and to investigate relationship with prognosis of these parameters. Materials, Methods & Results: Thirty calves with atresia coli and 6 healthy calves for control were used as material. Poor suction reflex, anorexia, dehydration, abdomen-kicking, frequent leg movement, abdominal distension and depression were observed in calves brought to the clinic. Some calves presented swashing sound depending on content of intestines when abdomen was shaken. Intestine atresia was diagnosed by history and clinical examination. After clinical examination, operation was performed. All calves were observed during 10 days after operation. Fifteen of 30 calves died during 10 days after operation. The blood lactate, WBC, LDH and CK-MB levels in non-surviving calves with atresia coli were significantly higher compared to control calves. The venous blood pH level was significantly lower in non-surviving calves compared to surviving calves. In addition, when compared to the control group, the blood pCO(2) level was significantly higher in non-surviving and surviving calves with atresia coli while the pO(2) and O-2 saturation levels were significantly lower. Discussion: In calves with intestinal atresia, hematologic parameters are normal in first 48 h of disease. However, leukocytosis and shift to the left have been reported over time. However, leukocytosis due to peritonitis, bacterial overgrowth, etc. have been reported over time. It was seen that leukocyte numbers of non-surviving calves with atresia coli in this study were significantly higher, but leucocyte increase in surviving calves was seen to be statistically insignificant. Leukocyte increased in non-surviving calves with atresia may be associated with excessive bacterial reproduction and peritonitis. Blood lactate level is a commonly used marker for severity of disease in humans and lactate has a prognostic value in adult horses with colic and foals with critical disease. In this study, lactate level in non-surviving calves with atresia coli was significantly higher with respect to surviving calves and control calves. In this result, lactate can be evaluated as a prognostic indicator in calves with atresia coli. Creatine kinase-MB fraction and troponins are used in determination of cardiac damage in veterinary medicine. The fact that serum blood cTnI and CK-MB levels of non-surviving calves with intestinal atresia in this study were higher than surviving calves with atresia coli and control calves suggested that endotoxemia related cardiac damage may have developed. Surgical operation is necessary in the treatment of intestinal atresia. It was determined that the importance of calves age and colon integrity during time of surgical operation in survival of calves with atresia coli. The studies showed that survival rate in surgical operation conducted on calves under 3 days old was higher than calves over 5 day-old. Average of age of non-surviving calves with atresia coli in this study (4.67 +/- 1.23 days) was higher than average of age of surviving calves with atresia coli (3.27 +/- 0.51 days). It was also observed in our study that elapsed time affected prognosis of calves negatively. Thus, performing surgical operations as soon as possible may raise survival rate of calves with intestinal atresia as stated in previous studies.Öğe Surgical treatment of a calf with jejunum intussusception: Case report(Selçuk Üniversitesi Veteriner Fakültesi, 2015) Erol, Muharrem; Erol, Hanifi; Koç, Yılmaz; Altan, SemihThe purpose of the present case report was to describe the clinical, laboratory and surgical findings of jejunum intussusception in a five-month old male calf. In this clinical case history, anorexia and lack of defecation for three days were learned from the owner. After clinical and laboratory examination the calf was referred to the Surgery Clinic. A leftflank laparotomy was performed. Intestines were examined for pathologic situation changes. During examination, solid consistency intestine segment was palpated at slight right of the ventral line. During macroscopic examination, invaginated intestine segment was detected as jejunum. Invaginated parts of intestine were edematous, cyanotic and fibrous adhesive, resection and end-to-end anastomosis were performed. The calf discharged was followed by owner. In conclusion, intussusceptions are rarely seen in five month old calves. Its diagnosis could be made by experimental laparotomy and intestine intussusceptions treated with routine surgical interventions in this period.Öğe The use of infrared thermography in the early diagnosis of septic arthritis in calves(Trakia University, 2022) Arıcan, Mustafa; Erol, Hanifi; Altan, Semih; Köylü, ÖznurThe aim of this study was to compare the usefulness of thermographic examination of calves with septic arthritis with other diagnostic techniques such as synovial fluid analysis, radiography, ultra-sonography and arthroscopy. Thirteen affected joints from eleven calves were used for the trial. The noninfected joints of the trial calves were used as negative controls. Thermography findings showed that heat from 100% of the affected joints was significantly increased. Subchondral osteolysis and new periosteal bone proliferation of articular bones and widening of the intra-articular joint spaces was observed in 10 joints (76.9%) using radiography. Ultrasound examination of all affected joints showed increased effusion with moderate homogeneous echoic structure. Arthroscopic examination showed synovitis and erosion of cartilage in 61.5% and osteophytic formation in 30.7% of affected joints. All diagnostic methods could be used to diagnose joint disease but it was found that thermo-graphic examination in calves with septic arthritis is an easy convenient method to make an earlier diagnosis, which improves treatment success rates.
