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    Enhancement of yogurt functionality by adding Mentha piprita phenolic extract and evaluation of its quality during cold storage
    (John Wiley and Sons Inc, 2024) Guemidi, Chafika; Ait Saada, Djamal; Ait Chabane, Ouiza; Elmastaş, Mahfuz; Erenler, Ramazan; Yılmaz, Mustafa Abdullah; Tarhan, Abbas
    New functional food products with health benefits are currently in high demand among health-conscious consumers. The present research aims to improve the func-tional properties of yogurt by adding peppermint hydroethanolic extract (PHE) at dif-ferent doses. The impact of PHE (0%, 2%, 4%, and 6%) on yogurt was studied for acidity, pH, organoleptic quality, antioxidant activity, lipid peroxidation, and fatty acid profile. The results revealed that PHE is rich in phenolic compounds, of which ros-marinic acid was the main one (339.88 mg/g lyophilized extract) and has considerable antioxidant potential, which remarkably (p< .01) increased antioxidant capacity in yo-gurt by over 39.51%, even at a low dose of 2%, giving the product better protection against lipid peroxidation and preserving its physicochemical and sensory quality. At 4%, PHE increased significantly (p< .01) the content of omega-3 fatty acids, nota-bly alpha- linolenic acid, in fortified yogurt compared with the control, and reduced (p< .01) the ratio of omega-6/omega-3, which dropped from 5.21 to 4.11. It looks feasible to prepare a yogurt with health- giving properties by adding Mentha piperitahydroethanolic extract at a concentration of up to 4% as an alternative to synthetic antioxidants, which would also extend its shelf life.
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    Phytochemical analysis and biological activity of Corchorus olitorius L.: Quantitative analysis of bioactive compounds by LC–MS/MS, antibacterial, enzyme inhibition, and cytotoxic activities
    (Elsevier GmbH, 2023) Atalar, Mehmet Nuri; Erenler, Ramazan; Turkan, Fikret; Alma, Mehmet Hakkı; Demirtaş, İbrahim; Baran, Ayşe; Kandemir, Sevgi İrtegün
    Introduction: Corchorus olitorius L. is a significant plant in folk medicine, therefore, research on phytochemistry with biological activity may reveal its potential use in drug development. Medicinal plants are valuable sources of drug materials as they include bioactive compounds known as secondary metabolites. Determination of bioactive compounds and biological activity of plants lead to understanding their potential in drug development. Methods: A quantitative analysis of the bioactive compounds in leaf, stem, and root extracts of C. olitorius L. was carried out with Liquid Chromatography-Mass Spectrometry (LC–MS/MS). Acetylcholinesterase (AChE) and Glutathione-S-Transferase (GST) enzyme inhibition and antibacterial effects were investigated using Mueller Hinton broth microdilution assay. The anticancer activity of C. olitorius leaves was evaluated by MTT assay using HDF, U87, Skov-3, and Caco-2 cell lines. Results: In the quantitative study, leaf extract exhibited the largest concentration of bioactive compounds, and cynarin (6.680 mg/g extract) and chlorogenic acid (5.605 mg/g extract) were the major products. The leaf, stem, and root extracts showed significant AChE and GST inhibition activity. The leaf extract displayed antibacterial activity against P. aeruginosa with the value of 2.2±0.1 (IC50, μg/ mL) in comparison to the standard (4.00±0.1 IC50, μg/ mL). The leaf extract displayed good antiproliferative activity against sk-ov-3 cell lines with values of 37.1% and 42.1% at 250 μg/mL and 500 μg/mL concentrations, respectively. Conclusion: C. olitorius has the potential to be a drug agent against cancer and microbial-induced diseases due to its effective bioactive compound contents.