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Öğe Massive hemolysis due to dacron patch leakage following repair of ventricular septal defect(2006) Göz M.; Çakir Ö.; Kilinç N.; Eren M.N.Massive hemolysis following closure of a ventricular septal defect (VSD) is rarely encountered complication. In this article, a case of 30 years-old male developed a severe degree of intravascular hemolysis within 24 hours due to residual shunt after a Dacron patch closure of ventricular septal defect. In early period, corticosteroid treatment was effective. To report, we discussed that corticosteroid therapy can be attempted before early reoperation.Öğe Penetrating heart wounds. An analysis of 29 cases.(2001) Ulkü R.; Eren S.; Balci A.; Ozçelik C.; Eren M.N.Twenty-nine cases, penetrating wounds to the heart, who were operated in the thoracic and cardiovascular surgery department of our University during January 1995-August 2000 were reevaluated. Twenty nine patients were men and the mean age was 22.6 (min 12, max 45). The cause of injury was stab wounds in 28 cases and gunshot wounds in 1 case. Besides the clinical findings; teleradiography, echocardiography were valuable for the diagnosis. Surgery was applied in emergent conditions for all cases. Interventions were performed 28 anterolateral thoracotomy, 1 bilaterally anterolateral thoracotomy and additionally 4 laparatomy were performed. The most frequent side of injury was right ventricule. Our mortality ratio was 17.2%, morbidity ratio 17.2%. We think that fast transportation, urgent diagnostic study and immediate surgical intervention important parameters which decrease of the mortality.Öğe Physiology and clinical role of salusin-? and salusin-? peptides in the cardiovascular system: Review(Turkiye Klinikleri, 2014) Aydin S.; Eren M.N.; Aydin S.Hypertension and atherosclerosis are the major cause of cardiovascular diseases and the leading cause of death globally. Some peptide hormones play key roles in the regulation of the pathogenesis of hypertension and atherosclerosis. In this sense, salusin-? (28 amino acids) and ? (20 amino acids) are two new important peptides that cause strong hypotension and bradycardia. Both peptides are broadly expressed in kidneys, blood vessels, hypothalamus, pituitary gland, (hypophysis) and human coronary atherosclerotic plaques, with dominance of salusin-? in macrophage foam cells, fibroblasts, and vascular smooth muscle cells (VSMCs), where it exerts different functions. Indeed, salusin-? had a role macrophage foam cell formation in the human, albeit salusin-? had not. Both salusin-? and salusin-? improved calcium uptake and protein synthesis in neonatal rat cardiomyocytes through the calcineurin, calcium, microtubule-associated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) and protein kinase C (PKC) signal pathways. As stated above, both salusin-? and -? were multifunctional bioactive peptide hormones, and both of them play a pivotal role in the maintenance of blood pressure homeostasis and the pathogenesis of atherosclerosis. Therefore this review focuses on role of salusin peptides in the cardiovascular system as they play a major role in regulating blood pressure and the pathogenesis of atherosclerosis. Copyright © 2014 by Türkiye Klinikleri.Öğe Primary giant hydatid cyst of the diaphragm.(2004) Eren S.; Ulku R.; Tanrikulu A.C.; Eren M.N.We report a case of an hydatid cyst of diaphragma in a 34-year-old female who was admitted to our clinic for right basithoracic pain. Magnetic resonance imaging (MRI) reported a giant hydatid cyst including multiple vesicles at the right lower thoracic cavity. Surgical exploration revealed an independent giant diaphragmatic hydatid cyst. We performed cystotomy and more than 200 daughter vesicles were removed from the cyst. The rest of the giant cyst cavity was excised.Öğe Tracheobronchial injuries(2003) Ulkü R.; Eren M.N.; Eren S.; Onat S.; Yavuz C.BACKGROUND: Tracheobronchial injuries are among the least common sort of thoracic traumas. This injury can be life threatening. However, successful diagnosis and treatment can prevent devastating acute or delayed complications. The aim of this study was to review the authors' surgical experience in tracheobronchial injuries. METHODS: We reviewed our records of 29 patients with tracheobronchial injuries from January 1979 to December 2000. The median age was 22.7. Twenty-seven patients were male and two were females. RESULTS: The causes of traumas were penetrating injury in seventeen, blunt injury in eleven patients and animal bite in one. In sixteen patients cervical trachea, in nine main stem bronchus, in 3 lobar bronchus and in one patient mediastinal trachea were found to be injured. In seven of twenty-nine patients there were combined tracheal and esophageal injuries. Surgical approach was made by oblique incision, collar incisions and thoracotomy. In general we preferred primary repair. The overall mortality rate was 24%. CONCLUSION: In our opinion, the number of complications and mortality can be diminished by early recognition of the injuries and treatment.Öğe Ventricular septal defectas a consequence of stab wound: Two-year follow-up without repair: Case report(2010) Ender Topal A.; Eren M.N.; Iltümür K.; Gümüş H.Many cases with penetrating cardiac injury are later diagnosed to have suffered injury also to one of the intracardiac structures, mostly interventricular septum. Even ventricular septal defect (VSD) was diagnosed preoperatively, immediate repair is not recommended unless intractable heart failure develops as VSD can shrink or even spontaneously close with time. We present a case of traumatic VSD whose VSD was diagnosed on the postoperative fifth day. He was followed up along two years without repair. Although defect size has enlarged, pulmonary-to-systemic blood flow ratio decreased to 0.94 from 1.4. It may be recommended that if a patient is asymptomatic there is no point in insisting on immediate VSD repair. Copyright © 2010 by Türkiye Klinikleri.
