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    High plasma nesfatin-1 level in patients with major depressive disorder
    (Pergamon-Elsevier Science Ltd, 2011) Ari, Mustafa; Ozturk, Oktay Hasan; Bez, Yasin; Oktar, Suleyman; Erduran, Dudu
    Aim: In the present study, our aim was to determine the changes in the plasma concentrations of a recently discovered peptide hormone nesfatin-1 in patients with major depressive disorder and then to make a comparison with the control group. Method: Subjects in the patient group were randomly selected from Mustafa Kemal University, Medical School, Research and Training Hospital, Psychiatry Department, Outpatient Clinic and subjects in the control group were selected from healthy volunteers. Healthy control subjects were matched in terms of weight and body mass index. Hamilton Depression Rating Scale (HAM-D) was applied to both groups. ELISA method was used for measurement of plasma nesfatin-1 levels. Results: The average nesfatin-1 level was statistically higher in patients with major depressive disorder than in the control group (p<0.001). A positive correlation was observed between plasma nesfatin-1 levels and HAM-D scores both in the patient group (r = 0.59, p<0.001) and in the control group (r = 0.58, p<0.001). Conclusion: Our findings suggest a possible relationship between major depressive disorder and high plasma nesfatin-1 level. (C) 2010 Elsevier Inc. All rights reserved.
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    Serum adiponectin and resistin levels in patients with obsessive compulsive disorder
    (Elsevier, 2012) Ari, Mustafa; Ozturk, Oktay Hasan; Bez, Yasin; Arica, Secil; Can, Yesim; Erduran, Dudu
    We aimed to investigate the changes in serum adiponectin and resistin levels in patients with obsessive compulsive disorder and control groups. The serum adiponectin and resistin levels of 29 patients (16 females, 13 males) with obsessive compulsive disorder and weight, age and sex-matched 31 healthy controls (17 females, 14 males) were determined. Yale-Brown Obsessive Compulsive Scale (Y-BOCS) was applied to all groups. ELISA method was used to measure adiponectin and resistin levels. The mean adiponectin level was 11.92 +/- 2.04 ng/ml and resistin level was 13.23 +/- 2.78 ng/ml in obsessive compulsive disorder group, while it was 18.81 +/- 5.24 ng/ml and 8.17 +/- 2.53 ng/ml in control group. Changes in plasma adiponectin and resistin levels in obsessive compulsive disorder may have implications about possible cardiovascular and metabolic abnormalities seen in obsessive compulsive patients. (C) 2011 Published by Elsevier B.V.