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Öğe Cis-platinum combination chemotherapy during pregnancy for mucinous cystadenocarcinoma of the ovary.: Case report(S O G Canada Inc, 1999) Bayhan, G; Aban, M; Yayla, M; Gül, T; Yaldiz, M; Erden, AC[Abstract Not Available]Öğe Lipid peroxidation, antioxidant defense, status of trace metals and leptin levels in preeclampsia(Elsevier Sci Ireland Ltd, 2005) Atamer, Y; Koçyigit, Y; Yokus, B; Atamer, A; Erden, ACObjective: To investigate the changes in enzyme activities of erythrocyte superoxide dismutase (SOD), catalase, and placental glutathione peroxidase (GSH-Px), and analyze the levels of serum malondialdehyde (MDA), copper (Cu), zinc (Zn), selenium (Se), leptin and placental MDA and glutathione (GSH). Study Design: Cross-sectional prospective study consisting of 32 preeclamptic (PE) pregnant, 25 non-pregnant (NP) women, 28 healthy pregnant (HP) women. Levels of lipid peroxides in serum and placenta, and activities of SOD, catalase in erythrocyte and placental GSH level, placental GSH-Px activity were measured by spectrophotometric methods. Serum levels of Cu, Zn, Se measured by atomic absorption spectrophotometry. Serum levels of leptin was measured by enzyme immunoassay by using the Cayman chemical kit. One-way analysis of variance and post hoc Tukey-HSD test and Pearson correlation test were used for the statistical analyses. Results: Serum levels of MDA, Cu, Leptin were markedly higher (P < 0.001); and serum level of Se was markedly lower (P < 0.001) in PE women compared with HP women and NP women. Also, placental MDA level was higher (P < 0.001) and placental GSH-Px activity was lower in PE women compared with HP women. In preeclamptic women erythrocyte catalase activity was markedly increased (P < 0.001), while erythrocyte SOD activity was markedly decreased (P < 0.001) compared to HP women and NP women. Placental GSH level was decreased compared to HP women (P < 0.001). Serum level of Zn was markedly decreased compared to NP women (P < 0.001) but no significant difference was observed in PE pregnant when compared with HP women (P > 0.05). Placental MDA level in PE women had significant negative correlation with serum Se level (r = -0.353, P < 0.05). A negative correlation was found between erythrocyte catalase activity with birth weight (r = -0.528, P < 0.001). Also, there were a significant negative correlation between serum levels of Cu and Se in the preeclamptic women (r = -0.407, P < 0.05). Conclusion: Our data demonstrate that elevation of lipid peroxides together with impaired antioxidant defense mechanisms and status of trace metals and the presence of possible interrelationship and crosstalk between those parameters may be related at least partly to the pathogenesis of preeclampsia. Additionally, lipid peroxides and blood oxidative imbalance could be part of the cytotoxic mechanisms leading to endothelial cell injury. (c) 2004 Elsevier Ireland Ltd. All rights reserved.Öğe Menstrual disorders and pelvic pain after sterilization(Kluwer Academic Publ, 1995) Taner, CE; Hakverdi, AU; Erden, AC; Satici, OChanges in menstrual cycle length, menstrual duration, number of pads, dysmenorrhea and non-cyclic pelvic pain were studied in 43 women following tubal sterilization with three different techniques. One group consisted of 17 women undergoing laparotomy by Pomeroy technique; the second group consisted of 11 women undergoing laparoscopy by Fallope rings; and the third group consisted of 15 women undergoing colpotomy by fimbriectomy. The differences before and after sterilization in cycle length were non-significant in all groups (p>0.05). After sterilization, menstrual duration and number of pads were significantly increased in the laparotomy (p<0.001) and laparoscopy (p<0.01) groups but non-significantly in the colpotomy group (p>0.05). Comparison of these parameters between the groups did not show any significant differences (p>0.05). After sterilization, increases in the severity of dysmenorrhea and non-cyclic pelvic pain were non-significant in all groups (p>0.05). We concluded that there were no significant differences in menstrual disorders after sterilization among these three different techniques.Öğe Prevalence, management and outcome in eclampsia(Wiley, 1996) Taner, CE; Hakverdi, AU; Aban, M; Erden, AC; Ozelbaykal, UObjective: To review the management of eclampsia in our institution. Method:The prevalence, management and outcome of women with eclampsia over a period of 8 years were reviewed at our referral medical center. There were 444 patients with eclampsia among 5757 deliveries (1 in 12.96 deliveries or 7.71% of deliveries). Most of the cases were uneducated and had received no antenatal care. One hundred eighty-one cases were nulliparous (40.77%). High parities of more than five were observed in 27.93% of cases. A standard magnesium sulfate regimen, similar to Prichard's intramuscular regimen, was used. Results: Magnesium sulfate effectively controlled the convulsions. The incidence of abdominal delivery among 397 cases with ante- and intrapartum eclampsia was 50.12%. Perinatal mortality was very high (591.47%0) for all cases. Maternal complications were serious and led to maternal death in 42 women (9.46%). Conclusion: Eclampsia is still a serious obstetric complication particularly in uneducated women who do not receive antenatal care.Öğe Primary gastric choriocarcinoma(I R O G Canada, Inc, 2000) Bayhan, G; Yaldiz, M; Yalinkaya, A; Kilinç, N; Gül, T; Erden, AC[Abstract Not Available]Öğe The relationship between plasma levels of leptin and androgen in healthy and preeclamptic pregnant women(Blackwell Munksgaard, 2004) Atamer, Y; Erden, AC; Demir, B; Koçyigit, Y; Atamer, ABackground To clarify the role of leptin and androgens in the pathogenesis of preeclampsia, we wanted to assess role of maternal leptin in women with severe and mild preeclampsia and the effects of sex steroid hormones on leptin production. Methods. The groups consisted of 40 healthy pregnant women (HPW) as well as 55 pregnant women with severe preeclampsia (SPE) and 41 pregnant women with mild preeclampsia (MPE). No significant differences were observed between the three groups regarding age, gestational age and body mass index (BMI). Plasma leptin, total testosterone (T), estradiol (EA dehydroepiandrosterone sulfate (DHEAS) and androstenedione (A) levels were measured. Statistical analysis was achieved with one-way analysis of variance (ANOVA) followed by post hoc multiple comparisons with the Tukey honestly significant difference (HSD) test by using SPSS for Windows statistical computer program, and the Pearson's coefficient of correlation was calculated. Results. The plasma level of leptin was significantly increased in the SPE and MPE groups (p < 0.001), whereas the plasma level of T was significantly increased only in the SPE group (p < 0.001). However, there was no significant difference in plasma levels of DHEAS among the three groups (p < 0.05). The plasma level of A was significantly decreased in the MPE group (p < 0.05). There was no significant difference in the plasma level of E-2 in the MPE and SPE groups (p < 0.05). There was a significant positive correlation between the plasma levels of leptin and E-2 in the MPE group (r = 0.41, P < 0.001). Conclusion. We concluded that the elevated plasma levels of leptin and testosterone could contribute to the endothelial dysfunction involved in the pathogenesis of preeclampsia, and that estradiol might lead to an increase in the plasma levels of leptin.Öğe A review of trophoblastic diseases at the medical school of Dicle university(Elsevier Sci Ireland Ltd, 1997) Gul, T; Yilmazturk, A; Erden, ACGestational trophoblastic disease cases encountered in 88 pregnant women during a period between January 1985 and June 1992 were retrospectively studied. During the same period we had 6800 deliveries. The incidence of gestational trophoblastic diseases was 12.9 per 1000 deliveries. Of these cases 72 (81.8%) were diagnosed as hydatidiform mole and 16 (18.2%) were diagnosed as choriocarcinoma in histopathological investigations. The preferred method of treatment for cases of hydatidiform mole was termination with suction curettage and oxytocin perfusion. Trophoblastic diseases were common in women with five or more pregnancies from rural areas and our incidence was higher when compared with similar studies. Moreover, our patients had low socio-economic and poor educational status. All these factors seem to be etiologic reasons, besides multiparity. (C) 1997 Elsevier Science Ireland Ltd.
