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    Antioxidative effects of alpha-lipoic acid in spinal cord injury An experimental rat model
    (Edizioni Luigi Pozzi, 2021) Ercan, Serdar; Aktaş, Ayfer; Kemaloğlu, Mustafa Serdar
    BACKGROUND: Traumatic and ischemic injuries of the spinal cord are effective in the development of neurological dysfunction of tissue damage caused by primary and secondary mechanisms. Free radical changes are effective in the development of early ischemia and progressive tissue ischemia is the main cause of secondary damage. Delaying ischemia is the basis of treatment. In this study, we aimed to demonstrate the presence of neuroprotective effects of alpha-lipoic acid in comparison with methylprednisolone. METHODS: 50 Sprague Dawley rats were divided into 5 groups (n = 10) and spinal cord trauma was created by the method, described by Rivlin and Tator. Group 1: Laminectomy group, Group 2: Laminectomy + spinal cord injury (SCI), Group 3: Laminectomy + SCI + alpha-lipoic acid (ALA) (100 mg / kg), Group 4: Laminectomy + SCl + Methyl-prednisolone (30 mg / kg), Group 5: Laminectomy + SCl + ALA + Methyl-prednisolone. RESULTS AND DISCUSSION: Rats with spinal cord injury were found to be paraplegic. There was no significant change in motor function between the groups. When the antioxidant values were compared in the groups, there was a statistically significant difference between Group 2 and Group 3. Oxygen radicals decreased significantly between ALA and Methylprednisolone. The most striking difference was between the monotherapy group and the combined treatment group. CONCLUSION: Our results showed that alpha lipoic acid given after spinal cord trauma in rats decreases anti-oxidant formation.
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    A Case of Growing Skull Fracture with Appearance of the Sinking Skin Flap Syndrome
    (Ortadogu Ad Pres & Publ Co, 2011) Ercan, Serdar; Senturk, Senem; Guzel, Aslan; Ceviz, Adnan
    A growing skull fracture is a late complication of a traumatic linear skull fracture. Untreated growing skull fractures can be associated with headache and progressive neurological deficits. In this case report, an unusual growing skull fracture mimicking sinking skin flap syndrome is presented. An 11-year-old girl, who had had a linear skull fracture 6 years previously, presented with headache, progressive left hemiparesis and right parietal scalp swelling on supine position. The scalp overlying the bone defect was sinking on upright position like the sinking skin flap syndrome. The growing skull fracture, revealed on the plain X-ray and computed tomography, was treated by duraplasty and cranioplasty with methylmetacrilate. The symptom of headache resolved and her walk improved after the treatment.
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    Öğe
    Civilian Gunshot Wound at the Occipitocervical Junction: An Unusual Case
    (Lippincott Williams & Wilkins, 2013) Ozkan, Umit; Kemaloglu, M. Serdar; Ozates, Mustafa; Ercan, Serdar
    We report the case of a 37-year old male patient was wounded at the face bay a gunshot. There was a single entrance wound, was detected at the right maxilla in the inspection. Cervical plain X rays a bullet was seen, between the axis and the occipital bone. It is very rare for an upper cervical injury not causing any neurological deficits at all. The aim of this case report is to prevent a case with a gunshot causing a clivus fracture by advancing to the adjacent dens between the occipital bone and the axis.
  • Küçük Resim
    Öğe
    Deneysel spinal kord travmasında alfa-lipoik asidin nöroprotektif etkilerinin metilprednizolone ile karşılaştırmalı incelenmesi
    (2016) Ercan, Serdar; Kemaloğlu, Mustafa Serdar
    Spinal kordun travmatik ve iskemik yaralanmaları primer ve sekonder mekanizmalarla oluşan doku hasarının nörolojik fonksiyon bozukluğunun gelişiminde etkindir. Monoaminler, serbest radikaller, nöropeptitler, araşidonik asit metabolitleri ve ekstraselüler Ca değişiklikleri erken dönem iskemi gelişiminde etkilidir ve ilerleyici doku iskemisi sekonder hasarın ana nedenidir. İskeminin geciktirilmesi tedavinin esasıdır. Alfa-Lipoik asitin diyabetik nöropatide noroprotektif ajan oldugu bilinmektedir. Spinal cord yaralanmalarinda Alfa-Lipoik asitin etkileri çalışılmamıştır. Bu calismada alfa-lipoik asidin noroprotektif etkilerinin varligi, ozellikle Metil-Prednizolone ile karsilastirmali olarak ortaya koymayi amacladık. METOD: 50 adet Sprague Dawley cinsi rat 5 gruba (n=10) ayrılarak Tator metodu ile spinal kord travması oluşturuldu.GrupI: Sadece laminektomi grubu, GrupII: Laminektomi +spinal cord injury (SCI) grubu, GrupIII: Laminektomi + SCI +alfa-lipoik asit (ALA)(100mg/kg), GrupIV: Laminektomi + SCl + Metil-prednisolone (30 mg/kg), GrupIV: Laminektomi + SCl + ALA + Metil-prednisolone grubu. Uygulamalardan 24 saat sonra tüm ratlardan Ketamin anestezi altında kan alındı hemen sonra spinal cord hasarlı bölgesinden biyokimya ve histopatolojik materyaller alındı. SONUÇ: Spinal cord hasarı yapılmış ratların plejik olduğu görüldü. Motor fonksiyonda Gruplar arasında bir değişiklik görülmedi. Anti oksidan değerlerin gruplar içinde karşılaştırılmasında GrupI ile ALA verilmiş grup arasında istatiksel olarak anlamlı bir fark olduğu görüldü (p<0.05). ALA verilen grup ile Metilprednizolon verilen grup arasında oksijen radikallerinin anlamlı olarak azaldığı görülmüştür. En dikkat çekici farklılık monoterapi verilen grup ile kombine tedavi verilen grup arasında oluşmuştur (p<0.05). Histopatolojik incelemede kombine tedavi verilen grupta vazodilatasyonun daha fazla olduğu görülmüştür. Sonuçlarımız ratlarda spinal cord travması sonrası verilen Alfa Lipoik asidin anti oksidan oluşumunu azalttığını göstermiştir. Anahtar Kelimeler: Spinal cord injury, Alfa-lipoik, Metil-prednisolone, oksijen radikalleri
  • Küçük Resim
    Öğe
    Neuroprotective effects of sildenafil on traumatic brain injury in an experimental rat model
    (Georg Thieme Verlag KG, 2021) Ercan, Serdar; Aktaş, Ayfer
    Objective Not only primary injuries, secondary injuries such as posttraumatic biochemical cascades, ischemia, and hypoxia also affect the morbidity and mortality of traumatic brain injury (TBI). Sildenafil released the vasodilatation by relaxing the smooth muscle of the systemic artery and vein. Also, the effects of sildenafil are evidenced in multiple sclerosis, Alzheimer's disease, and memory loss as a part of experimental studies. Sildenafil decreases oxidative stress by increasing the cGMP level. We aimed to examine the protective effects of sildenafil on TBI with histopathological and biochemical parameters. Method 21 Sprague-Dawley rats were separated into three groups (n = 7). "The weight drop injury model," which was described by Marmou, was used for the head injury. Group 1: nontraumatic sham group, Group 2: nontreated TBI group, Group 3: sildenafil (100 mg/kg) treated TBI group. The whole brain and serum were collected for histopathological and biochemical study. The histopathological sections were examined under a light microscope. Results On comparison of total antioxidant status (TAS), total oxidant status (TOS), nitric oxide (NO), and plasma nitrite/nitrate (PNOx) between groups, NO level was significantly high in group 3 (p = 0.013). Even though the TAS level was significantly high in group 3 (p = 0.02), there were no significant differences in TOS level in groups (p = 0.225). Disappearing Nissle granules occurred in a pyknotic situation in the cell nucleus, and acidophilic staining in neuron cells, which describe the neuron degeneration observed in the trauma group. The neuron degeneration markers were not seen in the sildenafil- treated trauma group. Conclusion Our study has shown that sildenafil decreases the oxygen radicals and affects the recovery of experimental TBI in rats.