Yazar "Eratilla V." seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • [ X ]
    Öğe
    Effects of nicotine on rat tongue mucosa: Histopathological and immunohistochemical analyses
    (Science Printers and Publishers Inc., 2016) Eratilla V.; Uysal I.; Deveci E.; Güneş R.F.; Eratilla E.; Yildiz I.; Söker S.
    OBJECTIVE: To evaluate the histopathological and immunohistochemical effects of systemically administered nicotine on rat tongue mucosa. STUDY DESIGN: Rats were assigned to one of two groups: the experimental group received nicotine systemically (nicotine sulphate 2 mg/kg subcutaneously daily for 28 days), while the rats in the control group were administered physiological saline (1.5 mL subcutaneously for 28 days). All animals were sacrificed at the end of the study, and tongue tissue samples were removed and prepared according to routine histological procedures. Sections were stained with hematoxylin and eosin and observed by light microscopy. Immunoreactivity of tongue mucosa was assessed with E-cadherin, collagen IV, and VEGF expression by immunohistochemical staining. RESULTS: There were significant differences in the average histopathological score between the nicotine-treated and untreated groups. Morphological changes, including inflammatory leukocyte infiltration and cellular desquamation, blood vessel dilation, hemorrhage, and epithelial degeneration, were noted. Further, E-cadherin expression was significantly decreased in the nicotine-treated group versus the untreated group. The nicotine treatment group showed an increase in collagen IV secondary papillae and basal cells. CONCLUSION: The increased level of VEGF expression in the nicotine-treated group may have affected endothelial cell apoptosis. © Science Printers and Publishers, Inc.
  • [ X ]
    Öğe
    The evalution of stress distributions in 3 and 5 unit dental and implant supported fixed zirconia restorations: Finite element analysis
    (Cumhuriyet University Faculty of Dentistry, 2015) Guven S.; Eratilla V.; Beydemir K.; Dundar S.
    Purpose: In this study, it is aimed to compare the distribution of stress on teeth and implants in 3-and-5-unit-dental and implant supported zirconia restorations by using finite element analysis. Material and Method: Stress distribution formed in teeth and implants as a result of chewing forces was analyzed in dental and implant (Astra Tech Microthread Osseo Speed, Sweeden) supported models of zirconia restoration with 5-unit placed on the numbers of 43, 44, 45, 46 and 47 and with 3-unit placed on the number of 45, 46 and 47. The study was performed through static nonlinear analysis with the three-dimensional finite element analysis method. Results: The highest and the lowest stress were respectively found on the number of 45 and 47 in 3-unit tooth supported model. The highest and the lowest stress in 5-unit tooth supported model were respectively found on the tooth of number 45 and on the root apex of the implant of number 43. Stress accumulation was observed in the cervical portion of the implant in implantsupported models. Stress accumulation in the tooth-supported model was found less than in implant-supported models Conclusion: The extreme forces on the dental and implant-supported restorations with increased units can reduce survival rate of restorations in mouth. In posterior restorations increased in the number of supported teeth and implant can reduce the destructive forces on teeth and implant and may allow longer period retention of the restorations in the mouth.